Trichopol tablets vaginal 500 mg, 10 pcs. (metronidazole)

Latin name

Trichopol

release form

white vaginal tablets with a yellowish tint.



packaging 10 pcs - blisters (1) - packs of cardboard.

Pharmacological action

Antiprotozoal drug with antibacterial activity, derivative of 5-nitroimidazole. The mechanism of action is the biochemical reduction of the 5-nitro group of metronidazole by intracellular transport proteins of anaerobic microorganisms and protozoa. The reduced 5-nitro group of metronidazole interacts with the DNA of the cell of microorganisms, inhibiting the synthesis of their nucleic acids, which leads to the death of microorganisms.

Metronidazole is active against Trichomonas vaginalis, Entamoeba histolytica, Gardnerella vaginalis, Giardia intestinalis, Lamblia spp. and obligate anaerobes Bacteroides spp. (including Bacteroides fragilis, Bacteroides distasonis, Bacteroides ovatus, Bacteroides thetaiotaomicron, Bacteroides vulgatus), Fusobacterium spp., Veillonella spp., Prevotella spp. (Prevotella bivia, Prevotella buccae, Prevotella disiens) of certain gram-positive microorganisms (Eubacterium spp., Clostridium spp., Peptococcus spp., Peptostreptococcus spp.). The MIC for these strains is 0.125-6.25 μg / ml.

In combination with amoxicillin, it is active against Helicobacter pylori (amoxicillin inhibits the development of resistance to metronidazole).

Metronidazole has no bactericidal effect against most bacteria and facultative anaerobes, fungi and viruses. In the presence of mixed flora (aerobes and anaerobes), metronidazole is synergistic with antibiotics effective against conventional aerobes.

Metronidazole increases the sensitivity of tumors to radiation, causes sensitization to ethanol (disulfiram-like effect), and stimulates reparative processes.

Indications

For topical treatment:

nonspecific vaginitis

bacterial vaginosis

trichomonas vaginitis.

Contraindications

blood disease

leukopenia (including a history)

impaired coordination of movements

organic CNS lesions (including epilepsy)

liver failure (for prescribing in high doses) srdlp pregnancy lactation (breastfeeding)

hypersensitivity to metronidazole or other nitroimidazole derivatives.

Use during pregnancy and lactation

Trichopolum is contraindicated for use in the first trimester of pregnancy. The use of the drug in the II and III trimesters is possible only in cases where the intended benefit to the mother outweighs the potential risk to the fetus.

If it is necessary to use Trichopolum during lactation, breast-feeding should be discontinued.

Composition

1 tab.

metronidazole 500 mg

Excipients: microcrystalline cellulose, povidone, crospovidone, colloidal silicon dioxide, stearic acid.

Dosage and administration of

With trichomonas vaginitis, the drug is prescribed 1 vaginal tablet per day for 7-10 days in combination with taking metronidazole tablets.

In case of nonspecific vaginitis, bacterial vaginosis, the drug is prescribed 1 vaginal tablet per day for 7 days, if necessary in combination with taking metronidazole tablets.

Treatment with metronidazole should not last more than 10 days and be repeated more often than 2-3 times a year.

The vaginal tablet should be removed from the contour packaging, moistened with boiled chilled water and inserted deep into the vagina.

Drug Interaction

The drug is compatible with sulfonamides and antibiotics.

Metronidazole causes ethanol intolerance, so alcohol should be avoided during treatment.

It is not necessary to combine metronidazole with disulfiram as at interaction of these preparations suppression of consciousness, development of mental disorders is possible.

When used with indirect anticoagulants (including warfarin), metronidazole enhances their action, leading to an increase in prothrombin time.

It is not recommended to use metronidazole in combination with non-depolarizing muscle relaxants (vecuronium bromide).

Under the influence of barbiturates, the effectiveness of metronidazole may be reduced due to the acceleration of its metabolism in the liver.

Cimetidine inhibits the metabolism of metronidazole, which may increase its plasma concentration and increase the risk of adverse reactions.

When co-administered with lithium, it is possible to increase its concentration in blood plasma.

Overdose

Overdose information on Trichopol® is not provided.

Storage conditions

The drug should be stored in a dry, dark place and out of the reach of children, at a temperature not exceeding 25 ° C.

Expiration

3 years.

Deystvuyuschee substances

metronidazole

Pharmacy terms of sale

Prescription

dosage form

Dosage form

tablets vaginal

Polpharma, Poland



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