Torvacard tablets 10 mg, 30 pcs. (Atorvastatin)
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$28.71
Regular Price
$29.00
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florida463611
Latin name
TORVACARD Buy Torvacard tablets 10 mg, 30 pcs. (Atorvastatin) in florida free shipping. Fast international shipping USA, AU, EU, UK and others.
TORVACARD Buy Torvacard tablets 10 mg, 30 pcs. (Atorvastatin) in florida free shipping. Fast international shipping USA, AU, EU, UK and others.
Latin name
TORVACARD
release form
film-coated tablets
Packing
30 pcs
Pharmacological action
Tobrex 2X has an antibacterial topical, anti-inflammatory topical effect. causes hypokalemia, while it is more active and its effect is longer.
The diuretic effect develops approximately one hour after taking the drug by mouth, reaching a maximum after 3–6 hours, and lasts from 8 to 10 hours.
Reduces SBP and DBP when lying and standing.
Pharmacokinetics
The drug Britomar in the dosage form of extended-release tablets provides a gradual release of torasemide, reducing fluctuations in its concentration in the blood, compared with the preparations of torasemide in the dosage form of tablets with conventional release.
Suction. After taking several doses of the drug, the relative bioavailability of the prolonged form, compared with the usual dosage form, is about 102%. The drug causes a pronounced and persistent increase in the activity of LDL receptors, and also has a beneficial effect on the quality of circulating LDL. Atorvastatin effectively reduces the level of LDL-C in patients with homozygous hypercholesterolemia, which is usually not amenable to therapy with other hypolipidemic agents.
When studying the dose dependence of the effect of atorvastatin, it was shown that the drug (at a dose of 10-80 mg) reduced the level of total cholesterol (by 30-46%), LDL-chs (by 41-61%), apolipoprotein B (by 34-50% ) and triglycerides (by 14-33%). The treatment results were similar in patients with heterozygous familial hypercholesterolemia, non-family forms of hypercholesterolemia and mixed hyperlipidemia (including in patients with non-insulin-dependent diabetes mellitus). Atorvastatin reduces the levels of total Chs, Chs-LDL, Chs-VLDL, apolipoprotein B, triglycerides and Chs, The primary target organ of atorvastatin is the liver, where cholesterol synthesis and LDL clearance are performed.
Dynamics of LDL-C levels correlates better with a dose of atorvastatin than with its plasma concentration. The dose of the drug should be selected taking into account the therapeutic effect.
Indications of
in combination with a diet to reduce elevated levels of total Chs, Chs-LDL, apolipoprotein B and triglycerides and increase the levels of Chs-HDL in patients with primary hypercholesterolemia, heterozygous familial and non-familial hypercholesterolemia (mixed cholesterol choleraemia) Fredrickson IIb)
in combination with a diet for the treatment of patients with elevated serum levels of triglycerides (Fredrickson type IV) and patients with dysbetalipoproteinemia (Fredrickson type III) who do not have dietary therapy gives an adequate effect of
to reduce the levels of total Chs and Chs-LDL in patients with homozygous familial hypercholesterolemia, when diet therapy and other non-pharmacological treatments are not effective enough.
Contraindications
active liver disease or increased serum transaminase activity (more than 3 times the upper normal range) of unknown origin
pregnancy
lactation period
children and adolescents under 18 years of age (efficacy and safety not established)
hypersensitivity to the components of the drug Torvakard.
Caution should be used in chronic alcoholism, a history of liver disease, severe electrolyte imbalance, endocrine and metabolic disorders, arterial hypotension, severe acute infections (sepsis), uncontrolled epilepsy, and extensive surgical interventions for injuries and skeletal muscle diseases.
Use during pregnancy and lactation
Atorvastatin is contraindicated in pregnancy and lactation (breastfeeding).
It is not known whether atorvastatin is excreted in breast milk. Given the possibility of adverse events in infants, if necessary, use of the drug during lactation should decide on the termination of breastfeeding. Women of reproductive age should use adequate methods of contraception during treatment. Atorvastatin can be prescribed to women of reproductive age only if their probability of pregnancy is very low, and the patient is informed about the possible risk of treatment for the fetus.
Composition of
1 tablet contains:
Active ingredient: atorvastatin (in the form of calcium salt) 10 mg
Excipients: heavy magnesium oxide, microcrystalline cellulose, lactose monohydrate, croscarmellose sodium, hydroxycitrate dihydroxymethyl cellulose.
Shell composition: hypromellose 2910/5, macrogol 6000, titanium dioxide, talc.
Dosage and administration of
Before prescribing Torvacard, the patient should be advised of a standard lipid-lowering diet, which he must continue to follow throughout the duration of therapy.
The initial dose is an average of 10 mg 1 time / day. The dose varies from 10 to 80 mg 1 time / day. The drug can be taken at any time of the day with food or regardless of the meal time. The dose is selected taking into account the initial levels of LDL-C, goals of therapy and individual effect. At the beginning of treatment and / or during an increase in the dose of Torvacard, it is necessary to monitor plasma lipid levels every 2-4 weeks and adjust the dose accordingly.
In primary hypercholesterolemia and mixed hyperlipidemia, in most cases, a dose of 10 mg of Torvacard 1 time / day is sufficient. A significant therapeutic effect is observed after 2 weeks, as a rule, and the maximum therapeutic effect is usually observed after 4 weeks. With prolonged treatment, this effect persists.
Side effects
Infectious and parasitic diseases: often - nasopharyngitis.
From the blood and lymphatic system: rarely - thrombocytopenia.
On the part of the immune system: often - allergic reactions are very rare - anaphylaxis.
From the side of metabolism and nutrition: often - hyperglycemia infrequently - hypoglycemia, weight gain, anorexia.
From the psyche: infrequently - sleep disturbances, including insomnia and nightmares.
From the nervous system: often - headache infrequently - dizziness, paresthesia, hypesthesia, taste perversion, loss or decrease in memory rarely - peripheral neuropathy.
From the side of the organ of vision: infrequently - decreased clarity of vision rarely - impaired vision.
On the part of the organ of hearing and labyrinthine disorders: infrequently - tinnitus is very rare - hearing loss.
From the respiratory system, chest and mediastinal organs: often - pain in the throat and trachea, nosebleeds.
From the digestive system: often - constipation, flatulence, dyspepsia, nausea, diarrhea infrequently - vomiting, pain in the upper and lower abdomen, belching, pancreatitis.
From the side of the liver and biliary tract: infrequently - hepatitis rarely - cholestasis very rarely - liver failure.
From the skin and subcutaneous tissues: infrequently - urticaria, skin rash, itching, alopecia rarely - angioedema, bullous dermatitis, including erythema multiforme, Stevens-Johnson syndrome and toxic epidermal necrolysis.
From the side of musculoskeletal and connective tissue: often - myalgia, arthralgia, pain in the extremities, muscle cramps, swelling of the joints, back pain infrequently - neck pain, muscle weakness rarely - myopathy, myositis, rhabdomyolysis, tendopathy (sometimes complicated by rupture) tendons).
General disorders and disorders at the injection site: infrequently - malaise, asthenia, chest pain, peripheral edema, increased fatigue, fever.
Laboratory and instrumental data: often - an increase in the activity of hepatic transaminases, an increase in the activity of CPK infrequently - leukocyturia, an increase in the concentration of glycosylated hemoglobin.
Drug Interaction
The risk of myopathy during treatment with other drugs in this class is increased with the concomitant use of cyclosporine, fibrates, erythromycin, antifungal drugs related to azoles, and niacin.
Plasma concentrations of atorvastatin decreased by approximately 35% with the concomitant administration of atorvastatin and a suspension containing magnesium and aluminum hydroxides, but the extent of the decrease in the level of Xc-LDL did not change.
Atorvastatin does not affect the pharmacokinetics of antipyrine when used concomitantly, so interactions with other drugs metabolized by the same cytochrome isoenzymes are not expected.
With concomitant administration of colestipol, atorvastatin plasma concentrations decreased by approximately 25%. However, the hypolipidemic effect of the combination of atorvastatin and colestipol was superior to that of each drug individually.
At repeated administration of digoxin and atorvastatin at a dose of 10 mg, the equilibrium concentrations of digoxin in the blood plasma did not change. However, when using digoxin in combination with atorvastatin at a dose of 80 mg / day, the concentration of digoxin increased by about 20%. Patients receiving digoxin in combination with atorvastatin require observation.
Atorvastatin and erythromycin (500 mg 4 times / day) or clarithromycin (500 mg 2 times / day), which inhibit the CYP3A4 isoenzyme, were co-administered with plasma concentrations of atorvastatin.
Atorvastatin (10 mg 1 time / day) and azithromycin (500 mg 1 time / day) concomitant plasma concentrations of atorvastatin did not change.
Atorvastatin did not have a clinically relevant effect on the plasma concentrations of terfenadine, which is metabolized mainly by CYP3A4 involvement, and it is therefore unlikely that atorvastatin is able to significantly affect the pharmacokinetic parameters of other CYP3A4 substrates.
With concomitant use of atorvastatin and an oral contraceptive containing norethindrone and ethinyl estradiol, there was a significant increase in the AUC of norethindrone and ethinyl estradiol by about 30% and 20%, respectively. This effect should be considered when choosing an oral contraceptive for a woman receiving atorvastatin.
No evidence of a clinically relevant interaction was observed in the study of the interaction of atorvastatin with warfarin and cimetidine.
Atorvastatin 80 mg and amlodipine 10 mg atorvastatin pharmacokinetics did not change at steady state.
The concomitant use of atorvastatin with protease inhibitors known as CYP3A4 isoenzyme inhibitors was accompanied by an increase in the concentration of atorvastatin in blood plasma.
No clinically relevant undesirable interaction of atorvastatin and antihypertensive agents, as well as with estrogens, was noted. No interaction studies were performed with all specific drugs.
Pharmaceutical incompatibility is unknown.
Overdose
Symptoms: Arterial hypotension possible.
Treatment: carrying out symptomatic therapy. There is no specific antidote. Hemodialysis is ineffective.
Storage conditions
The drug should be stored out of the reach of children at a temperature of 10 ° to 30 ° C.
Expiration
2 years.
Deystvuyuschee substances
Atorvastatin
Dosage form
Dosage form
tablets
Torvacard tablets 10 mg, 30 pcs. (Atorvastatin) florida in pharmacy online. Cheap price, instruction, side effects, dosage. Torvacard tablets 10 mg, 30 pcs. - Sale. PayPal accept. Free shipping florida. Fast international shipping.
TORVACARD
release form
film-coated tablets
Packing
30 pcs
Pharmacological action
Tobrex 2X has an antibacterial topical, anti-inflammatory topical effect. causes hypokalemia, while it is more active and its effect is longer.
The diuretic effect develops approximately one hour after taking the drug by mouth, reaching a maximum after 3–6 hours, and lasts from 8 to 10 hours.
Reduces SBP and DBP when lying and standing.
Pharmacokinetics
The drug Britomar in the dosage form of extended-release tablets provides a gradual release of torasemide, reducing fluctuations in its concentration in the blood, compared with the preparations of torasemide in the dosage form of tablets with conventional release.
Suction. After taking several doses of the drug, the relative bioavailability of the prolonged form, compared with the usual dosage form, is about 102%. The drug causes a pronounced and persistent increase in the activity of LDL receptors, and also has a beneficial effect on the quality of circulating LDL. Atorvastatin effectively reduces the level of LDL-C in patients with homozygous hypercholesterolemia, which is usually not amenable to therapy with other hypolipidemic agents.
When studying the dose dependence of the effect of atorvastatin, it was shown that the drug (at a dose of 10-80 mg) reduced the level of total cholesterol (by 30-46%), LDL-chs (by 41-61%), apolipoprotein B (by 34-50% ) and triglycerides (by 14-33%). The treatment results were similar in patients with heterozygous familial hypercholesterolemia, non-family forms of hypercholesterolemia and mixed hyperlipidemia (including in patients with non-insulin-dependent diabetes mellitus). Atorvastatin reduces the levels of total Chs, Chs-LDL, Chs-VLDL, apolipoprotein B, triglycerides and Chs, The primary target organ of atorvastatin is the liver, where cholesterol synthesis and LDL clearance are performed.
Dynamics of LDL-C levels correlates better with a dose of atorvastatin than with its plasma concentration. The dose of the drug should be selected taking into account the therapeutic effect.
Indications of
in combination with a diet to reduce elevated levels of total Chs, Chs-LDL, apolipoprotein B and triglycerides and increase the levels of Chs-HDL in patients with primary hypercholesterolemia, heterozygous familial and non-familial hypercholesterolemia (mixed cholesterol choleraemia) Fredrickson IIb)
in combination with a diet for the treatment of patients with elevated serum levels of triglycerides (Fredrickson type IV) and patients with dysbetalipoproteinemia (Fredrickson type III) who do not have dietary therapy gives an adequate effect of
to reduce the levels of total Chs and Chs-LDL in patients with homozygous familial hypercholesterolemia, when diet therapy and other non-pharmacological treatments are not effective enough.
Contraindications
active liver disease or increased serum transaminase activity (more than 3 times the upper normal range) of unknown origin
pregnancy
lactation period
children and adolescents under 18 years of age (efficacy and safety not established)
hypersensitivity to the components of the drug Torvakard.
Caution should be used in chronic alcoholism, a history of liver disease, severe electrolyte imbalance, endocrine and metabolic disorders, arterial hypotension, severe acute infections (sepsis), uncontrolled epilepsy, and extensive surgical interventions for injuries and skeletal muscle diseases.
Use during pregnancy and lactation
Atorvastatin is contraindicated in pregnancy and lactation (breastfeeding).
It is not known whether atorvastatin is excreted in breast milk. Given the possibility of adverse events in infants, if necessary, use of the drug during lactation should decide on the termination of breastfeeding. Women of reproductive age should use adequate methods of contraception during treatment. Atorvastatin can be prescribed to women of reproductive age only if their probability of pregnancy is very low, and the patient is informed about the possible risk of treatment for the fetus.
Composition of
1 tablet contains:
Active ingredient: atorvastatin (in the form of calcium salt) 10 mg
Excipients: heavy magnesium oxide, microcrystalline cellulose, lactose monohydrate, croscarmellose sodium, hydroxycitrate dihydroxymethyl cellulose.
Shell composition: hypromellose 2910/5, macrogol 6000, titanium dioxide, talc.
Dosage and administration of
Before prescribing Torvacard, the patient should be advised of a standard lipid-lowering diet, which he must continue to follow throughout the duration of therapy.
The initial dose is an average of 10 mg 1 time / day. The dose varies from 10 to 80 mg 1 time / day. The drug can be taken at any time of the day with food or regardless of the meal time. The dose is selected taking into account the initial levels of LDL-C, goals of therapy and individual effect. At the beginning of treatment and / or during an increase in the dose of Torvacard, it is necessary to monitor plasma lipid levels every 2-4 weeks and adjust the dose accordingly.
In primary hypercholesterolemia and mixed hyperlipidemia, in most cases, a dose of 10 mg of Torvacard 1 time / day is sufficient. A significant therapeutic effect is observed after 2 weeks, as a rule, and the maximum therapeutic effect is usually observed after 4 weeks. With prolonged treatment, this effect persists.
Side effects
Infectious and parasitic diseases: often - nasopharyngitis.
From the blood and lymphatic system: rarely - thrombocytopenia.
On the part of the immune system: often - allergic reactions are very rare - anaphylaxis.
From the side of metabolism and nutrition: often - hyperglycemia infrequently - hypoglycemia, weight gain, anorexia.
From the psyche: infrequently - sleep disturbances, including insomnia and nightmares.
From the nervous system: often - headache infrequently - dizziness, paresthesia, hypesthesia, taste perversion, loss or decrease in memory rarely - peripheral neuropathy.
From the side of the organ of vision: infrequently - decreased clarity of vision rarely - impaired vision.
On the part of the organ of hearing and labyrinthine disorders: infrequently - tinnitus is very rare - hearing loss.
From the respiratory system, chest and mediastinal organs: often - pain in the throat and trachea, nosebleeds.
From the digestive system: often - constipation, flatulence, dyspepsia, nausea, diarrhea infrequently - vomiting, pain in the upper and lower abdomen, belching, pancreatitis.
From the side of the liver and biliary tract: infrequently - hepatitis rarely - cholestasis very rarely - liver failure.
From the skin and subcutaneous tissues: infrequently - urticaria, skin rash, itching, alopecia rarely - angioedema, bullous dermatitis, including erythema multiforme, Stevens-Johnson syndrome and toxic epidermal necrolysis.
From the side of musculoskeletal and connective tissue: often - myalgia, arthralgia, pain in the extremities, muscle cramps, swelling of the joints, back pain infrequently - neck pain, muscle weakness rarely - myopathy, myositis, rhabdomyolysis, tendopathy (sometimes complicated by rupture) tendons).
General disorders and disorders at the injection site: infrequently - malaise, asthenia, chest pain, peripheral edema, increased fatigue, fever.
Laboratory and instrumental data: often - an increase in the activity of hepatic transaminases, an increase in the activity of CPK infrequently - leukocyturia, an increase in the concentration of glycosylated hemoglobin.
Drug Interaction
The risk of myopathy during treatment with other drugs in this class is increased with the concomitant use of cyclosporine, fibrates, erythromycin, antifungal drugs related to azoles, and niacin.
Plasma concentrations of atorvastatin decreased by approximately 35% with the concomitant administration of atorvastatin and a suspension containing magnesium and aluminum hydroxides, but the extent of the decrease in the level of Xc-LDL did not change.
Atorvastatin does not affect the pharmacokinetics of antipyrine when used concomitantly, so interactions with other drugs metabolized by the same cytochrome isoenzymes are not expected.
With concomitant administration of colestipol, atorvastatin plasma concentrations decreased by approximately 25%. However, the hypolipidemic effect of the combination of atorvastatin and colestipol was superior to that of each drug individually.
At repeated administration of digoxin and atorvastatin at a dose of 10 mg, the equilibrium concentrations of digoxin in the blood plasma did not change. However, when using digoxin in combination with atorvastatin at a dose of 80 mg / day, the concentration of digoxin increased by about 20%. Patients receiving digoxin in combination with atorvastatin require observation.
Atorvastatin and erythromycin (500 mg 4 times / day) or clarithromycin (500 mg 2 times / day), which inhibit the CYP3A4 isoenzyme, were co-administered with plasma concentrations of atorvastatin.
Atorvastatin (10 mg 1 time / day) and azithromycin (500 mg 1 time / day) concomitant plasma concentrations of atorvastatin did not change.
Atorvastatin did not have a clinically relevant effect on the plasma concentrations of terfenadine, which is metabolized mainly by CYP3A4 involvement, and it is therefore unlikely that atorvastatin is able to significantly affect the pharmacokinetic parameters of other CYP3A4 substrates.
With concomitant use of atorvastatin and an oral contraceptive containing norethindrone and ethinyl estradiol, there was a significant increase in the AUC of norethindrone and ethinyl estradiol by about 30% and 20%, respectively. This effect should be considered when choosing an oral contraceptive for a woman receiving atorvastatin.
No evidence of a clinically relevant interaction was observed in the study of the interaction of atorvastatin with warfarin and cimetidine.
Atorvastatin 80 mg and amlodipine 10 mg atorvastatin pharmacokinetics did not change at steady state.
The concomitant use of atorvastatin with protease inhibitors known as CYP3A4 isoenzyme inhibitors was accompanied by an increase in the concentration of atorvastatin in blood plasma.
No clinically relevant undesirable interaction of atorvastatin and antihypertensive agents, as well as with estrogens, was noted. No interaction studies were performed with all specific drugs.
Pharmaceutical incompatibility is unknown.
Overdose
Symptoms: Arterial hypotension possible.
Treatment: carrying out symptomatic therapy. There is no specific antidote. Hemodialysis is ineffective.
Storage conditions
The drug should be stored out of the reach of children at a temperature of 10 ° to 30 ° C.
Expiration
2 years.
Deystvuyuschee substances
Atorvastatin
Dosage form
Dosage form
tablets
Torvacard tablets 10 mg, 30 pcs. (Atorvastatin) florida in pharmacy online. Cheap price, instruction, side effects, dosage. Torvacard tablets 10 mg, 30 pcs. - Sale. PayPal accept. Free shipping florida. Fast international shipping.
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