Solpadein Fast soluble tablets No. 12

Release form, composition and packaging

?

Soluble tablets, white, flat, with a circumferentially cut edge and a line on one side.

1 tab.

paracetamol 500 mg

caffeine 65 mg

sorbitol, sodium saccharinate, sodium bicarbonate, povidone, sodium lauryl sulfate, dimethicone, citric acid, sodium carbonate.

2 pcs.

- laminated strips (4) - cardboard packs.

2 pcs.

- laminated strips (6) - cardboard packs.

pharmachologic effect

An analgesic-antipyretic combined composition, contains a combination of two active ingredients: paracetamol and caffeine.

It has antipyretic and analgesic effects.

Paracetamol blocks COX in the central nervous system, affecting the centers of pain and thermoregulation (in inflamed tissues, cellular peroxidases neutralize the effect of paracetamol on COX), which explains the almost complete absence of the anti-inflammatory effect.

The lack of influence on the synthesis of prostaglandins in peripheral tissues leads to the absence of a negative effect on water-salt metabolism (sodium and water retention) and the gastrointestinal mucosa.

Caffeine stimulates the psychomotor centers of the brain, has an analeptic effect, enhances the effect of analgesics, eliminates drowsiness and fatigue, and increases physical and mental performance.

Pharmacokinetics

Paracetamol is rapidly and almost completely absorbed from the gastrointestinal tract, the distribution in body fluids is relatively even.

The binding of paracetamol to plasma proteins is minimal at a therapeutic concentration.

Paracetamol is metabolized in the liver and excreted in the urine as glucuronide and sulfate metabolites - less than 5% is excreted unchanged.

T1 / 2 when taking a therapeutic dose is 2-3 hours. Caffeine is rapidly absorbed from the gastrointestinal tract and is distributed throughout the body.

Caffeine is almost completely metabolized in the liver by oxidation and demethylation in the form of metabolites, which are excreted in the urine.

T1 / 2 is 4-9 hours.

Indications for use

- headache

- migraine

- toothache

- neuralgia

- muscle and rheumatic pain

- painful menstruation

- sore throat

- to reduce fever and symptomatic treatment of colds and flu.

Contraindications for use

- hypersensitivity to drug components

- severe liver dysfunction

- severe renal dysfunction

- arterial hypertension

- glaucoma

- sleep disorders

- epilepsy

- children up to age 12

- deficiency of sucrase / isomaltase, fructose intolerance, glucose-galactose malabsorption (contains sorbitol).

The drug should be used with caution in case of benign hyperbilirubinemia (including Gilbert's syndrome), viral hepatitis, alcoholic liver damage, deficiency of glucose-6-phosphate dehydrogenase, alcoholism.

Dosage regimen

Before oral administration, Solpadein Fast tablets should be dissolved in at least 100 ml (half a glass) of water.

Adults (including the elderly) and children over 12 years of age are prescribed 1-2 tablets.

3-4 times / day, if necessary.

The interval between doses is at least 4 hours. The maximum single dose is 2 tablets, the maximum daily dose is 8 tablets.

The drug is not recommended to be used for more than 5 days when prescribed as an anesthetic and more than 3 days as an antipyretic without prescribing and supervising a doctor.

An increase in the daily dose of the drug or the duration of treatment is possible only under medical supervision.

Overdose

Symptoms caused by paracetamol: pallor of the skin, nausea, vomiting, anorexia, stomach pains are possible within 24 hours

after 1-2 days, signs of liver damage may appear (soreness in the liver area, increased activity of liver enzymes).

Perhaps a violation of carbohydrate metabolism and signs of metabolic acidosis.

In adult patients, liver damage develops after taking b

Name ENG

SOLPADEINE FAST

Clinical and pharmacological group

Analgesic antipyretic

ATX code

Paracetamol in combination with psycholeptics

Dosage

1 tab.

paracetamol 500 mg, caffeine 65 mg

Structure

Active ingredients: paracetamol 500 mg

caffeine 65 mg.

Excipients: sorbitol, sodium saccharinate, sodium bicarbonate, povidone, sodium lauryl sulfate, dimethicone, citric acid, sodium carbonate.

Indications

headache

migraine

toothache

neuralgia

muscle and rheumatic pain

painful periods

sore throat

to reduce fever and symptomatic treatment of colds and flu.

Contraindications

hypersensitivity to drug components

severe liver dysfunction

severe renal dysfunction

arterial hypertension

glaucoma

sleep disorders

epilepsy

children under 12 years of age

deficiency of sucrase / isomaltase, fructose intolerance, glucose-galactose malabsorption (contains sorbitol).

The drug should be used with caution in case of benign hyperbilirubinemia (including Gilbert's syndrome), viral hepatitis, alcoholic liver damage, deficiency of glucose-6-phosphate dehydrogenase, alcoholism.

Storage conditions and periods

At a temperature not higher than 25 degrees.

Expiration date: 4 years

INN / Active ingredient

Caffeine + paracetamol

Specifications

Category

Pain relievers

,

Migraine

,

Pain and fever

Scope of the medicinal product

General

Release form

Tablet

Manufacturer country

Greece

Package quantity, pcs

12

Minimum age from

12 years

Way of introduction

Through the mouth

Vacation conditions

Without recipe

Brand name

Solpadeine

The amount of the dosage form in the primary package

2 pcs.

Primary packaging type

Cell-free contoured packaging (strip)

Type of consumer packaging

Pack of cardboard

Pharmaco-therapeutic group

Pain reliever and antipyretic agent

Dosage form

Soluble tablets

The target audience

Children

Dosage (volume) of the substance in the preparation

paracetamol 500 mg

caffeine 65 mg

Expiration date in days

1461

Package weight, g

thirty

Mode of application

:

Before taking Solpadein Fast tablets, it should be dissolved in at least 100 ml (half a glass) of water. < br> Adults (including the elderly) and children over 12 years of age are prescribed 1-2 tablets.

3-4 times / day, if necessary.

The interval between doses is at least 4 hours. The maximum single dose is 2 tablets, the maximum daily dose is 8 tablets. < br> The drug is not recommended for more than 5 days when prescribed as an anesthetic and more than 3 days as an antipyretic without prescribing and monitoring doctor. < br> An increase in the daily dose of the drug or the duration of treatment is possible only under the supervision of a doctor.

Anatomical and therapeutic characteristics

:

N02BE71 Paracetamol, in combination with psychotropic drugs

Information on technical characteristics, delivery set, country of manufacture