Piracetam tablets 800 mg, 30 pcs. (Piracetam)

Latin name

Pyracetam

Packing

30 pcs

Pharmacological action

Piracetam activates associative processes in the central nervous system, improves mood, memory and mentality in sick and healthy people. Stimulates intellectual activity and integrative activity of the brain, facilitates learning processes, improves communication between the cerebral hemispheres and synaptic conduction in the cortex, increases mental performance, stabilizes and restores impaired brain functions (memory, consciousness, speech). Piracetam normalizes the ratio of ADP to ATP (inhibits nucleotide phosphatase and activates adenylate cyclase), increases the activity of phospholipase A, stimulates bioenergetic and plastic processes in the nervous tissue, and accelerates the exchange of neurotransmitters.

Piracetam increases the resistance of brain tissue to toxic effects and hypoxia, enhances the synthesis of phospholipids and nuclear RNA, enhances glycolytic processes and utilization of glucose in the brain. Piracetam blocks platelet aggregation, improves microcirculation, optimizes the ability of red blood cells to pass through microvessels and the conformational properties of the erythrocyte membrane, in ischemic areas of the brain increases regional blood flow. Piracetam enhances EEG beta and alpha activity and lowers delta activity. Reduces vestibular nystagmus. During hypoxia, intoxication, trauma, electroconvulsive effects, it has a neuroprotective effect.

Due to the antihypoxic effect, piracetam is effective in the complex treatment of myocardial infarction. Anxiolytic and sedative effects in piracetam are absent.

Piracetam is almost completely and rapidly absorbed after oral administration. Bioavailability is 100%. When ingested 2 g of the drug, the maximum plasma concentration is 40-60 mcg / ml after 30 minutes. Piracetam does not bind to plasma proteins. After 2-8 hours, the maximum concentration in the cerebrospinal fluid is created. Piracetam penetrates all tissues and organs, crosses the placental barrier. Almost not metabolized. It selectively accumulates in the cerebral cortex, mainly in the parietal, frontal and occipital lobes, basal ganglia and cerebellum. The half-life of piracetam from plasma is 4–5 hours from the cerebrospinal fluid is 6–8 hours. More than 95% of the drug is excreted unchanged by the kidneys after 30 hours. In patients with renal failure, the elimination half-life increases.

Indications

Chronic cerebrovascular insufficiency (hypertension, atherosclerosis, vascular parkinsonism), which is accompanied by impaired attention, memory, speech, headache and dizziness

ischemic stroke and its consequences

psycho-organic dementia, vascular disease, )

head injury

acute viral neuroinfection

intoxication (recovery period, coma and subcomatose state)

more the nervous system, which is accompanied by a decrease in the level of wakefulness,of the psychological complications of treatment with neuroleptics and other psychotropic drugs

neurotic depression with a predominance of senesto-hypochondriac and asthenic disorders in the clinical picture, adynamia, the phenomena of ideomotor inhibition

psycho-organic syndrome in chronic alcoholism

acute intoxication with morphine, ethanol, amphetamine,

barbiturates in children - cerebral palsy, consequences of perinatal th central nervous system, mental retardation, learning disabilities at low psychoorganic syndrome, speech disorder, mental retardation, memory impairment, encephalasthenia, intellectual impairment

sickle cell anemia (in the complex treatment).

Contraindications

Hypersensitivity (including pyrrolidone derivatives), severe renal failure (with creatinine clearance less than 20 ml / min), hemorrhagic stroke, Huntington's disease, agitated depression, breast-feeding, pregnancy, age up to 1 year.

Use during pregnancy and lactation

Piracetam is contraindicated during pregnancy. During therapy with piracetam, it is necessary to stop breastfeeding, since the drug passes into breast milk.

Composition

active substance: piracetam - 800 mg.

Dosage and Administration

Inside.

During meals or on an empty stomach, washed down with liquid.

Symptomatic treatment of the psycho-organic syndrome: 2.4 - 4.8 g per day in 2-3 doses.

Treatment of dizziness and related imbalance: 2.4 - 4.8 g per day in 2-3 doses.

Treatment of cortical myoclonus: start with a dose of 7.2 g per day, every 3-4 days the dose is increased by 4.8 g per day until the maximum dose of 24 g per day is reached in 2-3 doses. Treatment continues throughout the period of the disease. Every 6 months, attempts should be made to reduce the dose or discontinue the drug, gradually reducing the dose by 1.2 g per day every 2 days.

Treatment of sickle cell anemia: the daily prophylactic dose is 160 mg / kg body weight, divided into 4 equal doses.

Treatment of dyslexia in children (in combination with other methods of treatment): the recommended daily dose for children from 8 years old and adolescents is 3.2 g, divided into 2 doses.

Side effects

From the digestive system: rarely - dyspeptic symptoms, abdominal pain.

From the side of the central nervous system: rarely - nervousness, agitation, irritability, anxiety, sleep disorders, dizziness, headache, tremor, in some cases - weakness, drowsiness.

Other: increased sexual activity.

Drug Interaction

Increases the effectiveness of glucocorticoid (mutually) and antibacterial therapy for infectious and inflammatory diseases of the upper and lower respiratory tract.

Potentiates the bronchodilator effect of theophylline.

When prescribed with neuroleptics, it reduces the risk of extrapyramidal disorders.

overdose

Side effects are increased with piracetam overdose.

Treatment: gastric lavage, activated charcoal intake, no symptomatic treatment for a specific antidote, hemodialysis possible (50-60% efficacy).

Storage conditions

In a dry, dark place. Keep out of the reach of children.

Deystvuyushtee substance

Piracetam

Dosage form

tablets

Obolenskoye FP, Russia



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