Phthalazole tablets 500 mg, 10 pcs. (Phthalylsulfathiazole)

Release form

Tablets.

Packing

10 pcs.

Pharmacological action

Antibacterial agent, sulfanilamide derivative. It has a wide range of antimicrobial effects. Phthalylsulfathiazole is active against gram-positive and gram-negative microorganisms, including pathogens of intestinal infections. Poorly absorbed from the digestive tract. It acts mainly in the intestinal lumen, where the gradual release of the sulfanilamide moiety occurs.

The mechanism of action is associated with competitive antagonism with PABA and competitive inhibition of dihydropteroate synthetase, which leads to impaired synthesis of tetrahydrofolate acid, necessary for the synthesis of purines and pyrimidines.

Indications

Dysentery, colitis, gastroenteritis, bowel surgery (to prevent purulent complications).

Contraindications

Increased individual sensitivity to sulfanilamide drugs, blood system diseases, diffuse toxic goiter, kidney disease, acute hepatitis, intestinal obstruction

Special instructions

If necessary, it can be used simultaneously with sulfonamides or antibiotics with bacteriostatic effects.

Influence on the ability to drive vehicles and control mechanisms.

Caution should be exercised when driving vehicles and engaging in other potentially hazardous activities that require increased concentration of attention and speed of psychomotor reactions.

Composition

1 tablet contains:

active substance: phthalylsulfathiazole 500 mg.

Dosage and administration

Inside, for acute dysentery, adults in 1-2 days - 1 g 6 times a day, in 3-4 days - 1 g 4 times a day, in 5-6 days - 1 g 3 times a day. The average course dose is 25-30 g. After 5-6 days, the second course of treatment is carried out: 1-2 days - 1 g 5 times a day (in the afternoon - every 4 hours, at night - after 8 hours), 3-4 days - 1 g 4 times a day (do not give at night), 5 day - 1 g 3 times a day. The total dose in the second cycle is 21 g, with a mild course - 18 g.

Highest doses for adults: single - 2 g, daily - 7 g.

Children under 3 years old - 0.2 g / kg in 3 divided doses for 7 days , older than 3 years - 0.4-0.75 g 4 times a day.

For other infections, adults are prescribed 1-2 g every 4-6 hours in the first 2–3 days, half doses for children in the next 2–3 days — 0.1 g / kg / day in equal doses after 4 hours with a night break, the following days - 0.2-0.5 g every 6-8 hours.

Treatment with phthalazole, if necessary, is combined with the appointment of antibiotics. It is also advisable to prescribe, along with phthalazole, well-absorbable sulfanilamide preparations (sulfadimezin, etazol, etazol-sodium, etc.).

Side effects

Allergic reactions (rash, fever), deficiency of B vitamins (due to inhibition of intestinal microflora), agranulocytosis, aplastic anemia.

medicament

interaction When applying ftalazol conjunction with other drugs may The following interactions are observed: - PASK (paraaminosalicylic acid) and barbiturates - the activity of

sulfanilamides is enhanced - salicylates - the activity and toxicity of

is increased - methotrexate and diphenin - the toxicity of

is increased - thioacetazone, levomycetin - the possibility of developing agranulocytosis of srindromnolemia increases the risk of indirect anticoagulants - increased anticoagulant effect

- oxacillin - decreased antibiotic activity.

The combined use of phthalazole with acids and acid-reactive drugs, hexamethylenetetramine, an adrenaline solution is impractical, since they are chemically incompatible.

When using phthalazole with preparations containing para-aminobenzoic acid esters (novocaine, anestezin, dikain), the antibacterial activity of sulfonamide is inactivated by a competitive mechanism.

The effect is enhanced by antibiotics and well-absorbed sulfonamides.

Storage conditions

In a dry, dark place, at temperatures up to 25 ° C.

Deystvuyuschee substances

Phthalylsulfathiazole

Terms and conditions

prescription

Leka governmental form



Appointment

Vzrosl m in naznacheniyu wizard, Children prescribing

Dalhimpharm, Russia



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