Description

Dosage form

Oval, biconvex film-coated tablets, white or almost white, with a slightly glossy surface, engraved with A83" on one side, almost odorless.

The cross section is white or almost white.

Structure

Pill core

Active ingredients: potassium asparaginate 316.00 mg (in the form of potassium asparaginate hemihydrate 332.60 mg), magnesium asparaginate 280.00 mg (in the form of magnesium asparaginate tetrahydrate 350.00 mg)

Excipients: corn starch 172.20 mg, talc 20.00 mg, magnesium stearate 8.00 mg, potato starch 6.60 mg, povidone KZO 6.60 mg, colloidal silicon dioxide 4.00 mg

Tablet shell: talc 7.30 mg, butyl methacrylate copolymer 6.00 mg, titanium dioxide (color index: CI 77891, E171) 5.30 mg, macrogol-6000 1.40 mg.

pharmachologic effect

The most important intracellular cations of potassium (K +) and magnesium (Mg ++) play a key role in the functioning of numerous enzymes, in the formation of bonds between macromolecules and intracellular structures, and in the mechanism of muscle contractility. The intra- and extracellular ratio of potassium, calcium, sodium and magnesium ions affects myocardial contractility. Endogenous asparaginate acts as an ion conductor: it has a high affinity for cells, due to the slight dissociation of its salts, ions in the form of complex compounds penetrate into the cell. Magnesium asparaginate and potassium asparaginate improve myocardial metabolism. Lack of magnesium / potassium predisposes to the development of arterial hypertension, atherosclerosis of the coronary arteries, arrhythmias and metabolic changes in the myocardium.

Each tablet of PananginВ® Forte contains 280 mg of magnesium asparaginate and 316 mg of potassium asparaginate, which is 2 times higher than the content of active ingredients in PananginВ®, film-coated tablets.

The daily dose of PananginВ® Forte: 1 tablet 3 times a day, corresponds to the daily dose of PananginВ®: 2 tablets 3 times a day.

Taking a single dose of PananginВ® Forte in the form of one tablet makes the treatment more convenient for the patient.

Pharmacokinetics

Potassium and magnesium aspartates are intensively absorbed in the intestine, mainly in the small intestine.

Excreted by the kidneys.

Side effects

Possible nausea, vomiting, diarrhea, discomfort or burning sensation in the epigastric region (in patients with anacid gastritis or cholecystitis), atrioventricular block, paradoxical reaction (an increase in the number of extrasystoles), hyperkalemia (nausea, vomiting, diarrhea, paresthesia) (redness of the face) , feeling of thirst, lowering blood pressure, hyporeflexia, respiratory depression, convulsions).

If any of the listed adverse reactions become serious, or you notice the appearance of adverse reactions not listed in this leaflet, you should consult your doctor.

Selling features

Available without a prescription

Special conditions

Patients with diseases accompanied by hyperkalemia require special attention: regular monitoring of the potassium content in the blood plasma is necessary.

Influence on the ability to drive vehicles and mechanisms

No studies have been conducted.

It is not expected to affect the ability to drive vehicles and work with mechanisms that require increased concentration of attention and speed of psychomotor reactions.

Indications

To eliminate the deficiency of potassium and magnesium as part of combination therapy for various manifestations of coronary heart disease (including acute myocardial infarction)

chronic heart failure

cardiac arrhythmias (including arrhythmias caused by an overdose of cardiac glycosides).

Contraindications

Hypersensitivity to any of the constituent components of the drug, acute and chronic renal failure, hyperkalemia, hypermagnesemia, Addison's disease, atrioventricular block I-III with

Name ENG

PANANGIN FORTE

Clinical and pharmacological group

A drug that replenishes the deficiency of potassium and magnesium in the body

ATX code

Preparations of other mineral substances

Dosage

316mg + 280mg

Structure

Tablet core.

Active ingredients: potassium asparaginate 316.00 mg (in the form of potassium asparaginate hemihydrate 332.60 mg), magnesium asparaginate 280.00 mg (in the form of magnesium asparaginate tetrahydrate 350.00 mg)

Excipients: corn starch 172.20 mg, talc 20.00 mg, magnesium stearate 8.00 mg, potato starch 6.60 mg, povidone KZO 6.60 mg, colloidal silicon dioxide 4.00 mg

Tablet shell: talc 7.30 mg, butyl methacrylate copolymer 6.00 mg, titanium dioxide (color index: CI 77891, E171) 5.30 mg, macrogol-6000 1.40 mg.

Indications

to eliminate the deficiency of potassium and magnesium as part of combination therapy for various manifestations of coronary heart disease (including acute myocardial infarction)

chronic heart failure

cardiac arrhythmias (including arrhythmias caused by an overdose of cardiac glycosides).

Storage conditions and periods

At a temperature not higher than 25 degrees.

Expiration date: 3 years

INN / Active ingredient

magnesium asparaginate, potassium asparaginate

Contraindications

Hypersensitivity to any of the constituent components of the drug, acute and chronic renal failure, hyperkalemia, hypermagnesemia, Addison's disease, atrioventricular block I-III degree, shock (including cardiogenic) (blood pressure less than 90 mm Hg), impaired amino acid metabolism , severe myasthenia gravis, hemolysis, acute metabolic acidosis, dehydration state, age up to 18 years (efficacy and safety have not been established).

Specifications

Scope of the drug

Heart, vessels, blood

Release form

Tablet

Manufacturer country

Hungary

Package quantity, pcs

60

Way of introduction

Through the mouth

Vacation conditions

Without recipe

Brand name

Gedeon richter

The amount of the dosage form in the primary package

15 pcs.

Primary packaging type

Blister

Type of consumer packaging

Pack of cardboard

Pharmaco-therapeutic group

Potassium and magnesium drug

Anatomical and therapeutic characteristics

A12CX Other mineral preparations

Dosage form

Film-coated tablets

Expiration date in days

1095

Package weight, g

150