Description

Dosage form

Oral suspension

Structure

Paracetamol 120 mg

Excipients: malic acid, xanthan gum, maltitol (glucose syrup hydrogenate), sorbitol, citric acid, sodium nipasept, strawberry flavor, azorubin, water

pharmachologic effect

Analgesic antipyretic.

It has an analgesic and antipyretic effect.

Blocks cyclooxygenase in the central nervous system, affecting the centers of pain and thermoregulation.

There is practically no anti-inflammatory effect.

It does not affect the state of the gastrointestinal mucosa and water-salt metabolism, since it does not affect the synthesis of prostaglandins in peripheral tissues.

Pharmacokinetics

Absorption and distribution

The absorption is high.

Paracetamol is rapidly and almost completely absorbed from the gastrointestinal tract.

Cmax in plasma is reached after 30-60 minutes.

The connection with plasma proteins is about 15%.

The distribution of paracetamol in body fluids is relatively even.

Metabolism

It is metabolized mainly in the liver with the formation of several metabolites.

In newborns of the first two days of life and in children 3-10 years old, the main metabolite of paracetamol is paracetamol sulfate, in children 12 years and older - conjugated glucuronide.

Part of the drug (approximately 17%) undergoes hydroxylation with the formation of active metabolites, which are conjugated with glutathione.

With a lack of glutathione, these paracetamol metabolites can block the enzyme systems of hepatocytes and cause their necrosis.

Withdrawal

T1 / 2 when taking a therapeutic dose ranges from 2-3 hours. When taking therapeutic doses, 90-100% of the dose taken is excreted in the urine within one day.

The main amount of the drug is excreted after conjugation in the liver.

No more than 3% of the received dose of paracetamol is released unchanged.

Side effects

From the digestive system: sometimes - nausea, vomiting, pain in the stomach.

Allergic reactions: sometimes - skin rash, itching, urticaria, Quincke's edema.

From the hematopoietic system: rarely - anemia, thrombocytopenia, leukopenia.

When taken in recommended doses, paracetamol rarely has side effects.

If adverse reactions occur, you should immediately stop taking the drug and consult your doctor.

Selling features

Available without a prescription

Special conditions

Children from 2 to 3 months and children who are born prematurely Baby Panadol can only be given as directed by a doctor.

When conducting tests to determine the level of uric acid and the level of glucose in the blood serum, the doctor should be aware of the patient's use of the drug Children's Panadol.

When taking the drug for more than 7 days, it is recommended to control the parameters of peripheral blood and the functional state of the liver.

Indications

Used in children aged 3 months to 12 years:

- to reduce elevated body temperature against the background of colds, flu and childhood infectious diseases (including chickenpox, mumps, measles, rubella, scarlet fever)

- with toothache (including teething), headache, ear pain with otitis media and sore throat.

In children 2-3 months of age, a single dose is possible to lower body temperature after vaccination.

Contraindications

- severe violations of the liver or kidneys

- neonatal period

- hypersensitivity to paracetamol or any other component of the drug.

The drug should be used with caution in case of liver dysfunction (including Gilbert's syndrome), renal dysfunction, genetic absence of the enzyme glucose-6-phosphate dehydrogenase, severe blood diseases (severe anemia, leukopenia, thrombocytopenia).

The drug should not be taken simultaneously with other paracetamol-containing drugs.

Drug interactions

When using Children's Panadol together with barbiturates, diphenin, anticonvulsant

Name ENG

PANADOL BABY

Clinical and pharmacological group

Analgesic antipyretic

ATX code

Paracetamol

Dosage

120mg / 5ml x 100ml

Structure

Paracetamol 120 mg.

Excipients: malic acid, xanthan gum, maltitol (glucose syrup hydrogenate), sorbitol, citric acid, sodium nipasept, strawberry flavor, azorubin, water

Indications

Used in children aged 3 months to 12 years: to reduce fever against the background of colds, flu and childhood infectious diseases (including chickenpox, mumps, measles, rubella, scarlet fever)

with toothache (including teething), headache, ear pain with otitis media and sore throat.

In children 2-3 months of age, a single dose is possible to lower body temperature after vaccination.

Contraindications

Hypersensitivity to paracetamol or any other component of the drug

severe liver or kidney dysfunction

neonatal period.

The drug should be used with caution in case of liver dysfunction (including Gilbert's syndrome), renal dysfunction, genetic absence of the enzyme glucose-6-phosphate dehydrogenase, severe blood diseases (severe anemia, leukopenia, thrombocytopenia).

Storage conditions and periods

At a temperature not exceeding 30 degrees. (Do not freeze).

Expiration date: 3 years

INN / Active ingredient

Paracetamol

Specifications