Oxytocin injection for 5 IU 1 ml ampoule 10 pcs. (Oxytocin)

Latin name

Oxytocinum

Injection

Injection solution



packaging 10 pcs

The pharmacological action of

oxytocin is uterotonizing.

Enhances the permeability of the membranes of the myometrium cells for ions, increases its excitability and causes and enhances the contraction of the smooth muscles of the uterus.

Pharmacodynamics

Stimulates lactation, contributing to the reduction of myoepithelial cells of the mammary alveoli.

Indications

Stimulation of labor during postponement of pregnancy

stimulation and stimulation of labor in premature discharge of amniotic fluid, in primary or secondary labor weakness

cesarean section (during surgery)

management of labor in childbirth, or in childbirth , abortion (including termination of pregnancy of a long time)

lactostasis in the early postpartum period, painful premenstrual syndrome, accompanied by edema, increase of body weight.

Contraindications

Hypersensitivity, clinically narrow pelvis, improper position of the fetus, complete placenta previa, risk of uterine rupture.

Use during pregnancy and lactation

In the first trimester of pregnancy, oxytocin is used only for spontaneous or induced abortions.

Numerous data on the use of oxytocin, its chemical structure and pharmacological properties indicate that, following the instructions for use, oxytocin does not affect the formation of fetal malformations.

passes into breast milk in small amounts.

When using the drug to stop uterine bleeding, breastfeeding can be started only at the end of the course of treatment with oxytocin.

Composition of

1 ml of solution contains:

Active ingredient:

oxytocin

Excipients:

acetic acid glacial

chlorobutanol hemihydrate

ethanol (96%)

water for injection.

Dosage and administration

Intramuscularly, intravenously (single injection, drip), intranasally into the wall or vaginal part of the cervix.

During labor, intramuscularly - 1 IU with an interval of 30-60 minutes (depending on the reaction of the uterus) is more appropriate - intravenous drip (10-30 drops per minute) - 1-3 IU in 300-500 ml of 5% glucose solution (under the control of the frequency of uterine contractions and fetal heartbeats) before the end of childbirth and after separation of the placenta. To stimulate labor, intramuscularly - 0.5–1 IU with an interval of 30–60 minutes, can be administered intravenously (as for labor excitation), depending on the obstetric situation (opening of the uterine pharynx, etc.).

At birth in the pelvic presentation - 2-5 IU.

For hypotension and atony of the uterus - 5-10 IU, intravenously, in 10-20 ml of a 40% glucose solution. To stimulate lactation, intramuscularly or intranasally (using a pipette) - 0.5 IU 5 minutes before feeding, if necessary, repeat the injection.

In premenstrual syndrome - intranasally, from the 20th day of the cycle to 1 day of menstruation.

Side effects

Nausea, vomiting, arrhythmia, including in the fetus, bradycardia (of the mother and the fetus)

hypertension and subarachnoid bleeding or hypotension and shock

water retention (before poisoning) - with prolonged iv injection of

allergic reactions.

Drug Interaction

When administered oxytocin 3-4 hours after the use of vasoconstrictors with caudal anesthesia, severe arterial hypertension is possible.

With cyclopropane, halothane anesthesia, cardiovascular action of oxytocin may be altered with unexpected development of arterial hypotension, sinus bradycardia, and atrioventricular rhythm in the woman during anesthesia.

Overdose

Symptoms: depend mainly on the degree of hyperactivity of the uterus, regardless of the presence of hypersensitivity to the drug.

Hyperstimulation with hypertonic and tetanic contractions or with a base tone of 15-20 mm aq. Art. between the two contractions leads to disorderly labor, rupture of the body or cervix, vagina, bleeding in the postpartum period, uterine-placental insufficiency, bradycardia of the fetus, its hypoxia, hypercapnia, compression, birth trauma, or death.

Hyperhydration with convulsions as a result of the antidiuretic effect of oxytocin is a serious complication and develops with long-term administration of large doses (40-50 ml / min).

Treatment of hyperhydration: cancellation of oxytocin, restriction of fluid use, use of diuretics for boosting diuresis, intravenous administration of hypertonic saline solution, correction of electrolyte imbalance, relief of convulsions with appropriate doses of barbiturates and provision of professional care.

Storage conditions

At a temperature not exceeding 25 ° C. (do not freeze).

Shelf suitability

4 Year

Deystvuyuschee substances

Oxytocin

Pharmacy

Prescription

Dosage Form A dosage form

solution

for injection and infusion



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