Obolenskoe FP Nifural capsules 200mg # 16

Release form

Hard gelatin capsules No. 2 (for a dosage of 100 mg) or No. 0 (for a dosage of 200 mg) with a yellow body and lid.

The contents of the capsules are a mixture of powder and yellow granules.

pharmachologic effect

Pharmacotherapeutic group: antimicrobial agent - nitrofuran.

pharmachologic effect

Pharmacodynamics

Nifuroxazide is an intestinal antiseptic, a derivative of 5-nitrofuran, highly active against Campylobacter jejuni, Escherichia coli, Salmonella spp, Shigella spp

Clostridium perfingens, Vibrio cholerae, pathogenic Vibrions and Vibrio parahaemolytique, Staphylococcus spp.

Weakly sensitive to nifuroxazide: Citrobacter spp, Enterobacter cloacae and Proteus indologenes.

Resistant to nifuroxazide: Klebsiella spp, Proteus mirabilis, Providencia spp, Pseudomonas spp.

Nifuroxazide presumably inhibits the activity of dehydrogenases and protein synthesis in bacterial cells.

Does not cause the emergence of drug-resistant strains, and cross-resistance with other antibacterial drugs was not observed.

The effectiveness of nifuroxazide does not depend on the pH existing in the intestinal lumen, or on the sensitivity of microorganisms to antibacterial drugs.

Does not affect the composition of the normal bacterial flora of the digestive tract.

In case of acute bacterial diarrhea, it restores intestinal eubiosis.

When infected with enterotropic viruses, it prevents the development of bacterial superinfection.

Pharmacokinetics

After oral administration, nifuroxazide is practically not absorbed from the digestive tract and has its antibacterial effect exclusively in the intestinal lumen.

Nifuroxazide is excreted by the intestines: 20% is unchanged, and the rest of the amount of nifuroxazide is chemically altered.

Indications

Acute bacterial diarrhea, proceeding without deterioration of the general condition, fever, intoxication.

Contraindications

Hypersensitivity to nifuroxazide, nitrofuran derivatives or any excipients of the drug, sucrase / isomaltase deficiency, fructose intolerance, glucose-galactose malabsorption, pregnancy, children under 3 years of age.

Application during pregnancy and lactation

In animal studies, no teratogenic effect was found.

However, it is not recommended to take nifuroxazide during pregnancy as a precautionary measure.

Breastfeeding period

During the period of breastfeeding, it is possible to continue breastfeeding in case of a short course of drug treatment.

It is necessary to consult a doctor.

special instructions

When treating diarrhea concomitantly with nifuroxazide therapy, rehydration therapy is necessary.

In the case of bacterial diarrhea with signs of systemic damage (deterioration of the general condition, fever, symptoms of intoxication or infection), you should consult a doctor to decide on the appointment of systemic antimicrobials.

During drug therapy, alcohol is prohibited.

If symptoms of an allergic reaction appear (including shortness of breath, rash, itching), you should stop taking the drug.

It should be noted that 1 capsule with a dosage of 100 mg contains 0.036 g of sugar (sucrose), which is 0.0036 XE

1 capsule with a dosage of 200 mg contains 0.071 g of sugar, which is 0.0071 XE.

Influence on the ability to drive vehicles, mechanisms

The drug has no effect on the ability to drive vehicles and mechanisms.

Structure

1 capsule contains:

active substance: nifuroxazide 100/200 mg

auxiliary substances: sugar (sucrose), category extra", corn starch, microcrystalline cellulose, magnesium stearate

hard gelatin capsule: body and capsule cap - titanium dioxide, yellow iron oxide, gelatin.

Method of administration and dosage

It is used internally.

The capsule should be swallowed whole with a little water.

Children from 3 to 6 years old: 2 capsules of 100 mg or 1 capsule of 200 mg 3 times a day (the interval between doses is 8 hours).

Children from 6 to 18 years old: 2 capsules of 100 mg or 1 capsule of 200 mg 3-4 times a day (interval between doses 6-8 hours).

Adults: 2 capsules of 100 mg or 1 capsule of 200 mg 4 times a day (interval between doses is 6 hours).

The duration of the course of treatment is 5-7 days, but not more than 7 days.

If there is no improvement within the first 3 days of taking, then you should consult a doctor.

Use the drug only according to the method of administration and in the doses indicated in the instructions.

If necessary, please consult your doctor before using the medicinal product.

Side effects

Allergic reactions (skin rash, urticaria, Quincke's edema, anaphylactic shock).

If any of the side effects indicated in the instructions are aggravated, or you notice any other side effects not listed in the instructions, inform your doctor.

Drug interactions

Simultaneous use with drugs that cause the development of disulfiram-like reactions, drugs that inhibit the function of the central nervous system is not recommended.

If you are taking other medicines (including over-the-counter medicines) consult your doctor before use.

Overdose

Overdose symptoms are not known.

Treatment is symptomatic.

Storage conditions

Store in a dry, dark place at a temperature of 15-25 В° РЎ.

Shelf life

2 years

Active substance

Nifuroxazide

Name ENG

NIFURAL

Clinical and pharmacological group

Intestinal antiseptic.

Antidiarrheal drug

ATX code

Nifuroxazide

Dosage

200mg

Structure

1 capsule contains: active substance: nifuroxazide 100/200 mg excipients: sugar (sucrose), category "extra", corn starch, microcrystalline cellulose, magnesium stearate hard gelatin capsule: body and cap of the capsule - titanium dioxide, iron oxide yellow , gelatin.

Indications

Acute bacterial diarrhea, proceeding without deterioration of the general condition, fever, intoxication.

Contraindications

Hypersensitivity to nifuroxazide, nitrofuran derivatives or any excipients of the drug, sucrase / isomaltase deficiency, fructose intolerance, glucose-galactose malabsorption, pregnancy, children under 3 years of age.

Storage conditions and periods

In a dark place at a temperature not exceeding 25 degrees.

Expiration date: 3 years

INN / Active ingredient

Nifuroxazide

Specifications

Category

Diarrhea

Scope of the drug

Gastrointestinal tract

Release form

Capsules

Manufacturer country

Russia

Package quantity, pcs

16

Scope of application

Gastroenterology

Minimum age from

3 years old

Way of introduction

Through the mouth

Vacation conditions

Without recipe

Brand name

Obolenskoe FP

The amount of the dosage form in the primary package

8 pcs.

Primary packaging type

Blister

Type of consumer packaging

Pack of cardboard

Pharmaco-therapeutic group

Antimicrobial agent - nitrofuran

Anatomical and therapeutic characteristics

A07AX03 Nifuroxazide

Dosage form

Capsules

Packaging

Cardboard box

Dosage (volume) of the substance in the preparation

nifuroxazide 200 mg

The target audience

Adult

Expiration date in days

730

Package weight, g

twenty

Mode of application

:

It is used internally. The capsule should be swallowed whole with a little water. < br> Children from 3 to 6 years old: 2 capsules of 100 mg or 1 capsule of 200 mg 3 times a day (the interval between doses is 8 hours). < br> Children from 6 up to 18 years: 2 capsules of 100 mg or 1 capsule of 200 mg 3-4 times a day (interval between doses 6-8 hours). < br> Adults: 2 capsules of 100 mg or 1 capsule of 200 mg 4 times per day (interval between doses 6 hours). < br> The duration of the course of treatment is 5-7 days, but no more than 7 days. If there is no improvement within the first 3 days of taking, then you should consult a doctor. < br> Use the drug only according to the method of administration and in those doses indicated in the instructions. If necessary, please consult your doctor before using the medicinal product. < br>

Information on technical characteristics, delivery set, country of manufacture "