Nutriflex 40/80 solution for infusion 2000 ml double container 5 pcs. (Amino acids for parenteral nutrition, Other preparations Minerals)

Release form

Solution for infusion

Packing

5 containers of 2000 ml.

Pharmacological action

Nutriflex 40/80 - a means for parenteral nutrition.

Nutriflex contains in one bag chamber the amino acids that are the substrate for protein synthesis and the minerals needed to maintain water-electrolyte and acid-base balance, and in the second chamber - a glucose solution with electrolyte solutions.

Intravenously administered amino acids enter the intravascular and intracellular depots of endogenous free amino acids.

Introduction of all amino acids necessary for protein synthesis (including essential, conditionally interchangeable and interchangeable amino acids) contained in the preparation provides high nutritional efficiency and reduces the load on the body during protein synthesis.

this way The main therapeutic effect of Nutriflex 40/80 is to supply the body with a protein synthesis substrate and energy through glucose during parenteral nutrition.

Individual concentrations of amino acids in the preparation are selected so that upon intravenous administration of this solution, the increase in the concentration of each amino acid in the plasma does not go beyond the norm, which ensures the maintenance of the homeostasis of amino acids in the plasma.

Glucose is the most adapted energy carrier for the body and at the specified dose itself or together with an additionally introduced lipid emulsion covers the patient's needs for non-protein calories, protecting amino acids from inappropriate use.

The combination of the ingredients used in Nutriflex 40/80 at given concentrations, low osmolarity allows you to enter it through peripheral veins, which significantly expands the indications for its use in various categories of therapeutic and surgical patients, located both in intensive care units, and in outpatient and home settings.

Indications

Used for parenteral nutrition in inpatient and outpatient settings to cover the daily needs of patients for energy, amino acids, electrolytes and fluid during parenteral nutrition in patients with moderate to severe catabolism in cases where enteral nutrition is impossible, insufficient or contraindicated and also in combination with it, for example:

preoperative preparation of

condition after extensive surgery

moderate and severe trauma and the severity of burns



destructive inflammatory bowel disease (including Crohn's disease, intestinal fistulas)

short bowel syndrome

eating disorders (cachexia)

cancer

sepsis, peritonitis

acute pancreatitis

parenteral nutrition in patients with mechanical ventilation.

Contraindications

impaired amino acid metabolism

hyperkalemia

hyponatremia

impaired metabolism (e.g. with diabetes mellitus)

coma of unclear etiology

hyperglycemic / insulin insulin 2 years

individual intolerance to one of the components of the mixture.

General for parenteral nutrition:

severe circulatory disorders (collapse and shock)

severe tissue hypoxia

hyperhydration

disturbances of water-electrolyte balance

pulmonary edema

decompensated heart failure.

Special instructions

For complete parenteral nutrition Nutriflex 40/80 should be used in combination with lipid emulsions.

Before the start of infusion Nutriflex 40/80, the water-electrolyte balance and the acid-base state of the blood should be adjusted. Too fast administration of the drug can lead to volume overload, disruption of the water-electrolyte balance.

Control over blood sugar is needed. If hyperglycemia occurs, the rate of administration of Nutriflex 40/80 must be reduced or an appropriate dose of insulin should be administered.

Intravenous administration of amino acid solutions is accompanied by increased excretion of trace elements in the urine, especially copper and zinc. This must be taken into account when selecting doses of trace elements, especially during long-term therapy.

Due to the risk of pseudoagglutination, the use of the same infusion systems for the administration of blood products and multicomponent amino acid solutions is not recommended.

When the drug is administered, regular monitoring of the water-electrolyte balance and the acid-base state, blood sugar concentration, and serum ionograms should be carried out. During long-term therapy, monitoring of blood parameters (coagulogram, liver function indicators) is necessary.

If necessary, the addition of lipid emulsions, essential fatty acids, electrolytes, vitamins and minerals is possible.

As with all solutions administered intravenously, strict adherence to aseptic rules is required.

Nutriflex 40/80 is a multicomponent solution. When adding other solutions or a lipid emulsion to it, the compatibility of all ingredients must be considered.

The product is supplied in dual plastic containers for single use. Any unused volumes of the drug should not be stored and should be discarded.

The drug should be used immediately after mixing glucose and amino acid solutions. It is possible to store the drug after mixing glucose and amino acid solutions for up to 7 days at room temperature and up to 14 days when stored in the refrigerator (including the time of drug administration).

You can not use the drug if the solution is not transparent, there are obvious signs of damage on the container or its tightness is broken.

Composition

Isoleucine, srdnl

threonine,

tryptophan,

valine,

arginine monoglutamate,

histidine hydrochloride monohydrate,

alanine, aspartic acid,

glutamic acid,

glycine,

proline, serine,

magnesium acetate tetrahydrate,

sodium acetate trihydrate,

sodium dihydro

phosphate dihydrate,

potassium dihydrogen phosphate,

potassium hydroxide,

sodium hydroxide, srdlhydroglid sodium, potassium, calcium, magnesium, chloride, phosphate, nitrogen acetate.

Dosage and administration

Methods of preparing Nutriflex 40/80 for use:

Nutriflex 40/80 is a two-chamber bag, the compartments of which are separated by a special seam. One chamber is filled with a solution of amino acids and electrolytes, and the other with a solution of glucose and electrolytes.

Immediately before starting parenteral administration, solutions of amino acids, glucose and electrolytes should be mixed. To do this:

remove the two-chamber bag from its protective packaging, expand

and lay it out on a flat surface (on the table),

break the separation seam by pressing with one hand on one of the chambers of the bag,

pick up and mix the contents of both chambers, moving the right and left parts of the bag up and down.

After that, the solution is ready to use. At the end of the infusion, the bag is discarded.

If necessary, lipid emulsions can be added to Nutriflex 40/80 by introducing them into the finished solution through a special port located on the top of the bag. If you need to add other ingredients to the finished solution, you must use the additional port located below. All ingredients must be added in compliance with aseptic rules and taking into account their compatibility with each other.

Doses:

Selected according to individual needs. The maximum daily dose is 40 ml / kg / day, which corresponds to 1.6 g of amino acids / kg / day and 3.2 g of glucose / kg / day.

Speed ??of administration:

The maximum infusion rate is 2 ml / kg / h, which corresponds to 0.08 g of amino acids / kg / h and 0.16 g of glucose / kg / h.

Duration of use:

Introduction Nutriflex 40/80 is not recommended for more than seven days.

Precautions for use:

Caution is advised in patients with heart failure, severe hepatic and / or renal failure.

Nutriflex 40/80 is a special solution for administration to peripheral veins. When conducting therapy, it is necessary to take into account the condition of the veins and periodically change the place of administration of the solution.

Side effects

Side effects are very rare.

When therapy is discontinued, they are rapidly reversible.

The introduction of the drug can lead to allergic reactions, chills, nausea, and vomiting.

Due to the high osmolarity of the solution, in some cases, signs of increased diuresis may appear.

In such cases, the drug should be discontinued and resumed later at a lower rate of infusion.

In case of side effects that are not described in the instructions, patients should report them to their doctor.

Storage conditions

In the dark place at a temperature of no higher than 25 ° C.

Expiration

2 years

Active ingredient

Amino acids s for parenteral nutrition, Prochye Preparations Myneral

Terms of dispatch from srdlkrew pharmacies70 dprew13

dosage form

emulsion for infusion



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