Nurofen Express Lady tab. p / o 400mg # 12

Release form, composition and packaging

White coated tablets, round, biconvex, with red overprinting on one side

1 tab.

ibuprofen sodium dihydrate 512 mg,

which corresponds to the content of ibuprofen 400 mg

croscarmellose sodium - 60 mg, xylitol - 60 mg, microcrystalline cellulose - 60 mg, magnesium stearate - 16 mg, colloidal silicon dioxide - 4 mg

Shell composition: sodium carmellose - 1 mg, talc - 48 mg, acacia gum - 1.6 mg, sucrose - 186.2 mg, titanium dioxide (E171) - 3.3 mg, macrogol 6000 - 0.5 mg, red ink [Opakod S-1-15094] (shellac - 41.49%, iron dye red oxide (E172) - 31%, butanol * - 14%, isopropanol * - 7%, propylene glycol - 5.5%, aqueous ammonia - 1%, simethicone - 0.01%)

* Solvents evaporated after the printing process

6 pcs.

- blisters (1) - cardboard packs.

6 pcs.

- blisters (2) - cardboard packs.

12 pcs.

- blisters (1) - cardboard packs.

12 pcs.

- blisters (2) - cardboard packs.

pharmachologic effect

The mechanism of action of ibuprofen, a propionic acid derivative from the group of non-steroidal anti-inflammatory drugs (NSAIDs), is due to inhibition of the synthesis of prostaglandins - mediators of pain, inflammation and hyperthermic reaction.

Indiscriminately blocks COX-1 and COX-2, as a result of which it inhibits the synthesis of prostaglandins.

Has a fast directed action against pain (analgesic), antipyretic and anti-inflammatory action.

In addition, ibuprofen reversibly inhibits platelet aggregation.

Pharmacokinetics

Absorption and distribution Absorption - high, quickly and almost completely absorbed from the gastrointestinal tract.

After taking the drug on an empty stomach, Cmax of ibuprofen in blood plasma is reached after 30-35 minutes.

Taking the drug with food can increase Tmax.

Plasma protein binding over 90%.

It slowly penetrates into the joint cavity, is retained in the synovial fluid, creating higher concentrations in it than in the blood plasma.

Metabolism and excretion After absorption, about 60% of the pharmacologically inactive R-form is slowly transformed into the active S-form.

It is metabolized in the liver.

T1 / 2 - 2 hours. Excreted by the kidneys (unchanged, no more than 1%) and, to a lesser extent, with bile

In limited studies, ibuprofen has been found in breast milk at very low concentrations

Pharmacokinetics in special groups of patients In the elderly, there were no significant differences in the pharmacokinetic profile of the drug compared with younger people.

Indications for use

headache

migraine

toothache

painful periods

neuralgia

back pain

joint pain

muscle pain

rheumatic pains

fever with flu and colds.

Contraindications for use

hypersensitivity to ibuprofen or any of the components that make up the drug complete or incomplete combination of bronchial asthma, recurrent polyposis of the nose and paranasal sinuses, and intolerance to acetylsalicylic acid or other NSAIDs (including in history) erosive and ulcerative diseases of the gastrointestinal tract (including peptic ulcer and duodenal ulcer, Crohn's disease, ulcerative colitis) or ulcerative bleeding in the active phase or in history (two or more confirmed episodes of peptic ulcer or ulcerative bleeding) a history of bleeding or perforation of a gastrointestinal ulcer, provoked by the use of NSAIDs severe liver failure or active liver disease renal failure of severe severity (CC < 30 ml / min), confirmed hyperkalemia decompensated heart failure period after coronary artery bypass grafting cerebrovascular or other bleeding fructose intolerance, glucose-galactose malabsorption, sucrase-isomaltase deficiency hemophilia and other blood clotting disorders (including hypocoagulation), hemorrhagic diathesis III trimester pregnant

Name ENG

NUROFEN EXPRESS LADY

Clinical and pharmacological group

NSAIDs

ATX code

Ibuprofen

Dosage

400mg

Structure

One film-coated tablet contains: active ingredient - ibuprofen sodium dihydrate 512 mg (equivalent to ibuprofen 400 mg)

excipients: croscarmellose sodium 60 mg, xylitol 60 mg, microcrystalline cellulose 60 mg, magnesium stearate 16 mg, colloidal silicon dioxide 4 mg

shell composition: sodium carmellose 1 mg, talc 48 mg, acacia gum 1.6 mg, sucrose 186.2 mg, titanium dioxide (E171) 3.3 mg, macrogol-6000 0.5 mg, red ink [Opakod S-1 -15094] (shellac 41.49%, iron dye red oxide (E172) 31.00%, butanol 14.00%, isopropanol 7.00%, propylene glycol 5.50%, aqueous ammonia 1.00%, simethicone 0, 01%).

Indications

headache

migraine

toothache

painful periods

neuralgia

back pain

joint pain

muscle pain

rheumatic pains

fever with flu and colds.

INN / Active ingredient

ibuprofen

Contraindications

hypersensitivity to ibuprofen or any of the components that make up the drug

complete or incomplete combination of bronchial asthma, recurrent polyposis of the nose and paranasal sinuses, and intolerance to acetylsalicylic acid or other NSAIDs (including in history)

erosive and ulcerative diseases of the gastrointestinal tract (including peptic ulcer and duodenal ulcer, Crohn's disease, ulcerative colitis) or ulcerative bleeding in the active phase or in history (two or more confirmed episodes of peptic ulcer or ulcerative bleeding)

a history of bleeding or perforation of a gastrointestinal ulcer, provoked by the use of NSAIDs

severe liver failure or active liver disease

renal failure of severe severity (CC < 30 ml / min), confirmed hyperkalemia

decompensated heart failure

period after coronary artery bypass grafting

cerebrovascular or other bleeding

fructose intolerance, glucose-galactose malabsorption, sucrase-isomaltase deficiency

hemophilia and other blood clotting disorders (including hypocoagulation), hemorrhagic diathesis

III trimester of pregnancy

children under 12 years of age.

Precautions for use

If you have the conditions listed in this section, you should consult your doctor before using the drug.

Concomitant use of other NSAIDs, a history of a single episode of gastric ulcer or gastrointestinal ulcer bleeding gastritis, enteritis, colitis, presence of Helicobacter pylori infection, ulcerative colitis bronchial asthma or allergic diseases in the exacerbation phase or in history - the development of bronchospasm is possible systemic lupus erythematosus or mixed connective tissue disease (Sharp's syndrome) - increased risk of aseptic meningitis renal failure, incl. with dehydration (CC less than 30-60 ml / min), nephrotic syndrome, hepatic failure, liver cirrhosis with portal hypertension, hyperbilirubinemia, arterial hypertension and / or heart failure, cerebrovascular diseases, blood diseases of unknown etiology (leukopenia and anemia), severe somatic diseases, dyslipidemia / hyperlipidemia,diabetes mellitus, peripheral arterial disease, smoking, frequent alcohol consumption, phenylketonuria or phenylalanine intolerance, concomitant use of drugs that may increase the risk of ulcers or bleeding, in particular, oral corticosteroids (including prednisone), anticoagulants (including including warfarin), selective serotonin reuptake inhibitors (including citalopram, fluoxetine, paroxetine, sertraline) or antiplatelet agents (including acetylsalicylic acid, clopidogrel), I-II trimesters of pregnancy, breastfeeding, elderly age.in particular, oral corticosteroids (including prednisone), anticoagulants (including warfarin), selective serotonin reuptake inhibitors (including citalopram, fluoxetine, paroxetine, sertraline) or antiplatelet agents (including . acetylsalicylic acid, clopidogrel), I-II trimesters of pregnancy, period of breastfeeding, old age.in particular, oral corticosteroids (including prednisolone), anticoagulants (including warfarin), selective serotonin reuptake inhibitors (including citalopram, fluoxetine, paroxetine, sertraline) or antiplatelet agents (including . acetylsalicylic acid, clopidogrel), I-II trimesters of pregnancy, the period of breastfeeding, old age.

Storage conditions and periods

At a temperature not higher than 25 degrees.

Expiration date: 2 years

Specifications

Category

Pain relievers

Scope of the medicinal product

General

Release form

Tablet

Manufacturer country

Great Britain

Package quantity, pcs

12

Minimum age from

12 years

Way of introduction

Through the mouth

Vacation conditions

Without recipe

Brand name

Reckitt benckiser

The amount of the dosage form in the primary package

12 pcs.

Primary packaging type

Blister

Type of consumer packaging

Pack of cardboard

Pharmaco-therapeutic group

NSAIDs

Anatomical and therapeutic characteristics

M01AE01 Ibuprofen

Dosage form

Film-coated tablets

Dosage (volume) of the substance in the preparation

400 mg

The target audience

Children

Expiration date in days

730

Package weight, g

twenty

Mode of application

:

Read the instructions carefully before taking the drug < br> For oral administration.

For short-term use only < br> Adults and children over 12 years of age, by mouth, 1 tablet (400 mg) up to 3 times a day.

The tablets should be taken with water.

The interval between taking the drug should be at least 4 hours < br> The maximum daily dose is 1200 mg (3 tablets) < br> The maximum daily dose for children from 12-17 years is 800 mg (2 tablets) < br> If when taking the drug within 2-3 days the symptoms persist or worsen, it is necessary to stop treatment and consult a doctor < br> If you need to take the drug for more than 10 days, you should consult a doctor.

Information on technical characteristics, delivery set, country of manufacture