Novobismol tablets are covered.pl.ob. 120 mg 112 pcs. (Vysmuta trykalyya dytsytrat)

Release form

tablets

Packaging

112 pcs.

Pharmacological action

Novobismol is an anti-ulcer agent with bactericidal activity against Helicobacter pylori.

It also has anti-inflammatory and astringent effects.

In an acidic environment of the stomach aboutit develops insoluble bismuth oxychloride and citrate, and chelating compounds with a protein substrate are formed in the form of a protective film on the surface of ulcers and erosion.

Increasing the synthesis of prostaglandin E, the formation of mucus and the secretion of bicarbonate, stimulates the activity of cytoprotective mechanisms, increases the resistance of the gastrointestinal mucosa to the effects of pepsin, hydrochloric (hydrochloric) acid, enzymes and bile salts.

Leads to the accumulation of epidermal growth factor in the defect area. Reduces the activity of pepsin and pepsinogen.

Indications

Peptic ulcer of the stomach and duodenum in the exacerbation phase (including associated with Helicobacter pylori) chronic gastritis and gastroduodenitis in the exacerbation phase (including associated with Helicobacter pylori) irritable bowel syndrome, occurring mainly with symptoms of diarrhea, functional dyspepsia, not associated with organic gastrointestinal diseases.

Contraindications

Severe renal impairment, pregnancy, lactation, hypersensitivity to bismuth tripotassium dicitrate.

Use during pregnancy and lactation

Use during pregnancy and during lactation (breastfeeding) is contraindicated.

Special instructions

Novobismol should not be used for more than 8 weeks.

During treatment, it is not recommended to exceed the established daily doses for adults and children.

At the end of the course of treatment in recommended doses, the concentration of the active substance in the blood plasma does not exceed 3-58 mcg / L, and intoxication is observed only at a concentration of more than 100 mcg / L.

Against the background of application, stool may be stained black due to the formation of bismuth sulfide. Sometimes a slight darkening of the tongue is noted.

Active substances:

bismuth tricamide, mg mg, mg starch - 70.6 mg,

povidone K 30 - 17.7 mg,

potassium polyacrylate - 23.6 mg,

macrogol 6000 - 6.0 mg,

magnesium stearate - 2.0 mg

Dosage and administration of

Adults and children 4 years of age and older, 2–4 times a day, 30 minutes before meals. The dose of Novobismol depends on the age of the patient.

The course of treatment is 4-8 weeks. Over the next 8 weeks, bismuth-containing preparations should not be taken.

To eradicate Helicobacter pylori, it is advisable to use bismuth tripotassium dicitrate in combination with antibacterial drugs with anti-Helicobacter pylori activity.

Side effects

From the digestive tract: nausea, vomiting, frequent stools, constipation.

Allergic reactions: skin rash, itching.

Other: prolonged use at high doses - encephalopathy associated with the accumulation of bismuth in the central nervous system.

Drug Interactions

While taking other drugs, as well as food and liquids, in particular antacids, milk, fruits and fruit juices, a change in the effectiveness of bismuth tripotassium dicitrate is possible.

Storage Conditions

In a dry, dark place at a temperature not exceeding 25 ° C.

Term hodnosty

4 years

lekarstvennaja form

tablets

pharm, Russia



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