Norvir tablets coated. captivity. about. 100 mg 90 pcs. (Rytonavyr)

Packing

90 pcs. - plastic bottles (1) - packs of cardboard.

Pharmacological action

Antiviral. It has a selective affinity for HIV aspartyl protease and therefore has a weak inhibitory effect on the corresponding human protease.

In vitro studies have shown that ritonavir has a pronounced inhibitory effect on the replication of both laboratory and clinical strains of HIV.

Ritonavir is almost completely metabolized in the liver.

Indications

As part of combination therapy for HIV infection in adults and children older than 3 years.

Contraindications

Hypersensitivity use of amiodarone, astemizole, itraconazole, ketoconazole, bepridyl, cisapride, bupropion, clozapine, dihydroergotamine, ergotamine, propininidene, propininidene, pyrenefinonefinone, pyreninidene, pyrenefinonefinone, pyrenefinamine, pyrenefinamine, pyrenefinamine, pyrenefinamine, pyrenefenoxide, complications).

Use during pregnancy and lactation

There are currently no adequate data on the use of ritonavir in pregnant women.

The use of the drug during pregnancy is possible only if the intended benefit to the mother outweighs the potential risk to the fetus.

HIV-infected women should not breast-feed their children to avoid transmission of HIV.

Composition

1 capsule contains 100 mg ritonavir.

Dosage and administration of

Inside (preferably with meals). Adults - 600 mg 2 times a day (to reduce the risk of side effects, start with 300 mg 2 times a day, increasing by 100 mg daily).

In children, the initial dose is 250 mg / m2, then it is increased by 50 mg / m2 every 2-3 days - up to 400 mg / m2 2 times a day. It is recommended to start treatment with monotherapy, after 2 weeks nucleoside preparations are added.

Side effects

Nausea, vomiting, diarrhea, anorexia, abdominal pain, loss of taste, paresthesia, asthenia, headache, dehydration, renal failure, fever, skin rash, rarely - hyperglycemia with signs of diabetes.

Drug Interaction

Increases the effect of potent sedatives and hypnotics (lorazepam, flurazepam, diazepam, estazolam, midazolam, trizolam, zolpidem). Phenobarbital, carbamazepine, dexamethasone, phenytoin, rifampin and rifabutin decrease activity. Clarithromycin, desipramine and saquinavir increase antiviral activity, oral contraceptives, theophylline - decrease.

Overdose

There are limited reports of acute overdose in humans.

Symptoms: A patient receiving 1500 mg / day of ritonavir for two days had paresthesias that stopped with a decrease in the dose of the drug. In another case, the development of renal failure accompanied by eosinophilia was reported.

Treatment: Supportive activities, including monitoring of vital indicators and the patient's condition. Washing the stomach through a probe and introducing activated charcoal is recommended. There is no specific antidote. Because ritonavir is extensively metabolized by the liver and largely bound to plasma proteins, dialysis will be ineffective to remove large amounts of the drug.

Storage conditions

The drug can be stored for 30 days without a refrigerator, in a dark place at a temperature of 25 ° C.

In the refrigerator, at a temperature of 2–8 ° C.

Keep out of the reach of children.

Expiration

1 year.

Active ingredient

ritonavir

Dosage form

Dosage form

tablets



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