Norfloxacin tablets is covered.pl.ob. 400 mg 10 pcs. (norfloxacin)

release form

tablets zrdlkp tablets66r66 ska

Tablets

Packing

Per pack of 10

Pharmacological action

Norfloxacin - an antibacterial agent.

It is used to treat infectious and inflammatory diseases such as pyelonephritis, cystitis, urethritis, gonorrhea, prostatitis, intestinal infections, ophthalmic and ENT infections.

Indications

Infections caused by microorganisms sensitive to norfloxacin: urinary tract infections (except for acute and chronic complicated pyelonephritis), prostatitis, uncomplicated gonorrhea.

Contraindications

Hypersensitivity

tendonitis, tendon rupture caused by fluoroquinolones (including history)

pregnancy, lactation, childhood, glucose-6-phosphate dehydrogenase deficiency.

Use during pregnancy and lactation

The drug is contraindicated for use by pregnant women and women during lactation.

If used during lactation, breast-feeding must be discontinued.

Composition

1 tablet contains:

Active ingredient:

norfloxacin 400 mg

Excipients:

silicon dioxide colloidal (aerosil),

magnesium stearate,

microcrystalline cellulose, microcrystalline sodium.

Dosage and Administration

Inside.

In case of urinary tract infections - 400 mg 2 times a day for 7-10 days with uncomplicated cystitis - 3-7 days for chronic recurrent urinary tract infections - up to 12 weeks.

In acute bacterial gastroenteritis - 5 days.

In acute gonococcal urethritis, pharyngitis, proctitis, cervicitis - once 800 mg.

With typhoid fever - 400 mg 3 times a day for 14 days.

For the prevention of sepsis - 400 mg 2 times a day.

For the prevention of bacterial gastroenteritis - 400 mg / day.

For the prevention of travelers' diarrhea - 400 mg / day 1 day before departure and during the entire period of the trip (no more than 21 days).

For the prevention of recurrence of urinary tract infections - 200 mg / day.

In patients with impaired renal function with a CC more than 20 ml / min, dosage adjustment is not required. With CC below 20 ml / min (or a serum creatinine concentration of more than 5 mg / 100 ml), hemodialysis patients are prescribed 1/2 therapeutic dose 2 times a day or a full dose 1 time per day.

Side effects

From the central nervous system (CNS): dizziness, headache, tingling in the fingers, drowsiness, anxiety, depression, insomnia, sleep disturbance.

From the digestive system: nausea, abdominal pain, anorexia, diarrhea, pain in the rectum or anus, constipation, dyspepsia, flatulence, vomiting, dry mucous membrane of the oral cavity, heartburn, unformed stool, bitter taste in the mouth, ulceration of the oral mucosa, itching of the anus.

From the hemopoietic organs: leukopenia, thrombocytopenia, eosinophilia, neutropenia.

From the skin: itching, rash, erythema, urticaria.

On the part of the sensory organs: blurred visual perception.

From the side of the musculoskeletal system: bursitis, swelling of the hands and feet.

From the side of the cardiovascular system (CVS): myocardial infarction, sensation of palpitations.

From the urinary system: renal colic.

Laboratory indicators: increased activity of AST, ALT, alkaline phosphatase, LDH, proteinuria, decreased hematocrit and Hb, increased blood urea concentration, hypercreatininemia, glucosuria.

Other: hyperhidrosis, asthenia, back pain, fever, chills, chest pain, dysmenorrhea, edema, allergic reactions.

Drug Interaction

When co-administered with norfloxacin with warfarin, the anticoagulant effect of the latter is enhanced.

When concomitant administration of norfloxacin with cyclosporine increases the concentration of the latter in blood plasma.

When co-administered with norfloxacin and antacids or preparations containing iron, zinc, magnesium, calcium or sucralfate, the absorption of norfloxacin is reduced due to the formation of complexes with metal ions (the interval between their intake should be at least 4 h).

At the same time, norfloxacin reduces theophylline clearance by 25%, so the dose of theophylline should be reduced when used concomitantly.

Concomitant administration of norfloxacin with medicinal products, having the potential to lower blood pressure can cause a sharp decrease in blood pressure. In this regard, in such cases, as well as with the simultaneous administration of barbiturates, anesthetics, the heart rate, blood pressure, ECG parameters should be monitored. Concomitant use with drugs that reduce the epileptic threshold can lead to the development of epileptiform seizures.

Reduces the effect of nitrofuran.

Overdose

In case of overdose, the stomach should be cleaned by causing vomiting or by washing the stomach with a probe, and the patient should be carefully examined and treated for symptomatic and supportive treatment.

It is necessary to monitor the water-salt metabolism, the patient should receive a large amount of fluid to avoid the formation of stones in the urinary tract.

Storage conditions

Store the drug at a temperature not exceeding 25 ° C, out of the reach of children.

Expiration

2 years.

Deystvuyuschee substances

norfloxacin



pharmacy terms and conditions

Dosage form

Dosage form

tablets

Vertex, Russia



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