Nookholin Romfarm solution for in / ven. and w / mouse. dosing 250 mg / ml 4 ml ampoules 3 pcs. (Choline alfostserat)

Packing

3 ampoules of 4 ml.

Pharmacological action

Nooholin Rompharm - a nootropic drug, central cholinomimetic with a primary effect on the central nervous system. The drug contains 40.5% metabolically protected choline. Choline alfoscerate in the body under the influence of brain enzymes is broken down into choline and glycerophosphate. Choline is involved in the synthesis of acetylcholine, transmitting nerve impulses and improving brain function, and glycerophosphate is a precursor of phosphatidylcholine neuron membranes.

Choline alfoscerate improves cerebral blood flow, strengthens metabolic processes in the brain, activates the structure of the reticular formation of the brain and restores consciousness in traumatic brain damage.

Clinical studies have shown that choline alfoscerate stimulates dose-dependent release of acetylcholine under physiological conditions of neurotransmission.

Pharmacokinetics

Distribution

Easily penetrates into various tissues and organs, including to the brain.

Excretion

It is excreted mainly by the lungs in the form of carbon dioxide (85%), and also excreted by the kidneys and through the intestines (15%).

Indications

acute period of traumatic brain injury with predominantly stem lesion level

psycho-organic syndrome against the background of degenerative and involutional changes in the brain

consequences of cerebrovascular insufficiency (impaired mental function)

multi-infarct dementia.

Contraindications

Hemorrhagic stroke (acute stage) hypersensitivity to the drug.

Ingredients

Active ingredient: choline alfoscerate 250 mg

Excipient: water

Dosage and administration of

In acute conditions - intramuscularly or intravenously (slowly), 1 g per day for 15-20 days then go on oral administration of 0.8 g in the morning and 0.4 g in the afternoon for 6 months.

Side effects

From the digestive system: constipation, diarrhea, dry oral mucosa, pharyngitis.

From the nervous system: headache, drowsiness, insomnia, aggression, anxiety, nervousness, cerebral ischemia, dizziness.

From the skin: rash, urticaria.

Other: pain at the injection site, increased urination.

Overdose

Symptoms: in case of an overdose, nausea is noted that disappears after a dose reduction or treatment discontinuation.

Treatment: symptomatic treatment.

Storage conditions

In the dark place at a temperature of 15 ° C.

Expiration

2 years.

Deystvuyuschee substances

Choline alfostserat

Pharmacy terms

Prescription

Dosage form

solution for injections and infusions

K.O. Rompharm Company S.R.L., Romania



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