Nicotinic acid bufus Renewal injection solution 1% 1 ml ampoule 10 pcs. (Nykotynovaya acid)

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Latin name

Nicotinic acid bufus Buy Nicotinic acid bufus Renewal injection solution 1% 1 ml ampoule 10 pcs. (Nykotynovaya acid) in florida free shipping. Fast international shipping USA, AU, EU, UK and others.
Latin name

Nicotinic acid bufus

Injection

Injection solution



packaging 10 pcs

Pharmacological action

Nicotinic acid Bufus inhibits lipolysis in adipose tissue, reduces the rate of VLDL synthesis. It normalizes the lipid composition of the blood: reduces the level of total cholesterol, LDL, triglycerides and increases the level of HDL, has antiatherogenic properties.

Has a vasodilating effect, including on the vessels of the brain, improves microcirculation, increases the fibrinolytic activity of the blood and reduces platelet aggregation (reduces the formation of thromboxane A2).

Promotes the conversion of the trans form of retinol to the cis form used in the synthesis of rhodopsin. Promotes the release of histamine from the depot and the activation of the kinin system.

Has detoxification properties. It is effective in Hartnup disease - a hereditary metabolic disorder (absorption and penetration into the tissues) of tryptophan, accompanied by a deficiency in the synthesis of nicotinic acid.

Pharmacokinetics

Well absorbed in the pyloric stomach and upper duodenum. It partially biotransforms in the liver with the formation of N-methylnicotinamide, methylpyridonecarboxamides, glucuronide and a complex with glycine. It is excreted in the urine, mainly unchanged.

Indications

Prevention and treatment of pellagra (vitamin deficiency PP)

atherosclerosis, hyperlipidemia (including hypercholesterolemia, hypertriglyceridemia), peripheral vascular spasm, including obliterating endarteritis, Raynaud’s disease, migraine, cerebrovascular accident, including ischemic stroke (complex therapy), angina pectoris, Hartnap’s disease, hypercoagulation, facial neuritis, intoxication, long-term healing wounds, ulcers, infectious diseases, gastrointestinal diseases.

Contraindications

Hypersensitivity, peptic ulcer of the stomach and duodenum (in the acute stage), severe dysfunction of the liver, gout, hyperuricemia, severe forms of arterial hypertension and atherosclerosis (iv).

Use during pregnancy and lactation

Precautions during pregnancy and lactation (high doses are contraindicated).

Composition of

1 ampoule of injection contains:

Active ingredient:

nicotinic acid 10 mg.

Dosage and administration

Slowly, intramuscularly, subcutaneously, intravenously.

For prevention: by mouth, for adults - 0.0125–0.025 g per day, for children - 0.005–0.025 g per day.

For pellagra: for adults, by mouth, 0.1 g 2–4 times a day for 15–20 days or iv 0.05 g or i / m 0.1 g 1-2 times a day within 10-15 days to children - inside, at 0.0125-0, 05 g 2-3 times a day.

For ischemic stroke: iv, 0.01–0.05 g.

For atherosclerosis: inside, 2-3 g per day in 2–4 doses.

In case of lipid metabolism disorders: by mouth, the dose is gradually increased (in the absence of side effects) from 0.05 g once a day to 2-3 g per day in several doses, the course of treatment is 1 month or more, breaks are required between repeated courses .

For other diseases: by mouth, adults - 0.02-0.05 g (up to 0.1 g) 2-3 times a day, children - 0.0125-0.025 g 2-3 times a day.

Side effects

Due to the release of histamine: redness of the skin, incl. face and upper half of the body with a sensation of tingling and burning sensation, a rush of blood to the head, dizziness, hypotension, orthostatic hypotension (with rapid intravenous administration), increased secretion of gastric juice, itching, dyspepsia, urticaria.

With prolonged use of large doses: diarrhea, anorexia, vomiting, impaired liver function, fatty liver, ulceration of the gastric mucosa, arrhythmia, paresthesia, hyperuricemia, decreased glucose tolerance, hyperglycemia, transient increase in AST activity, LDH, alkaline phosphatase, irritation gastrointestinal mucosa.

Drug Interaction

Potentiates the action of fibrinolytic agents, antispasmodics and cardiac glycosides, the toxic effect of alcohol on the liver.

Reduces the absorption of bile acid sequestrants (an interval of 1.5–2 h between doses is required) and the hypoglycemic effect of anti-diabetic drugs.

Possible interaction with antihypertensives, acetylsalicylic acid, anticoagulants.

Storage Conditions

In a dark place at a temperature not exceeding 25 ° C.

Shelf life

3 years

Active ingredient

Nicotine acid

Terms and conditions

prescription

dosage form

injection

Indications

Indications

from cerebrovascular disorder, gastritis, From Raynaud’s disease, With diabetic nephropathy, From wounds, From vascular damage in diabetes mellitus, From neuritis, From hypovitaminosis

PFC Update, Russia



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