Migraine tab. p / o captivity. 65mg + 500mg # 20

Dosage form

Tablets are oval, biconvex, coated, white or almost white in color with a line on one side.

The cross section shows two layers.

The color of the core without a shell is white or almost white.

Structure

active substances: paracetamol - 0.500 g, caffeine - 0.065 g.

excipients: potato starch, microcrystalline cellulose, croscarmellose sodium, hyprolose (hydroxypropyl cellulose), colloidal silicon dioxide, magnesium stearate, copovidone, talc, titanium dioxide, silicone emulsion (50% solution).

pharmachologic effect

Migraine is a combined drug, the action of which is determined by the components that make up it.

Caffeine has a psychostimulant (stimulates the psychomotor centers of the brain), analeptic effect, enhances the effect of analgesics, eliminates drowsiness and fatigue, increases physical and mental performance. Affects the cardiovascular system: increases the frequency and strength of heart contractions (HR), increases blood pressure (BP) during hypotension (does not change normal). Expands the bronchi, bile ducts, blood vessels of skeletal muscles, heart, kidneys, narrows the vessels of the abdominal organs. Reduces platelet aggregation. Stimulates the secretion of gastric glands, increases the basal metabolism, has a moderate diuretic effect.

Paracetamol - antipyretic and analgesic effect (due to inhibition of cyclooxygenase (COX) and inhibition of prostaglandin (Pg) synthesis, it affects the center of thermoregulation in the hypothalamus and conduction of pain impulses in the central nervous system (CNS). The drug blocks cyclooxygenase I and II mainly in the central nervous system (CNS). , acting on the centers of pain and thermoregulation.In inflamed tissues, cellular peroxidases neutralize the effect of paracetamol on cyclooxygenase, which explains the almost complete absence of anti-inflammatory effect in it.The drug does not have a negative effect on water-salt metabolism (sodium and water retention) and mucous membrane of the gastrointestinal tract (GIT) due to the lack of influence on the synthesis of prostaglandins in peripheral tissues The possibility of methemoglobin formation is unlikely.

Pharmacokinetics

Caffeine and its water-soluble salts are well absorbed in the intestine (including the colon).

The half-life of the drug (T1 / 2) is about 5 hours, in some individuals - up to 10 hours. The main part is demethylated and oxidized.

About 10% is excreted unchanged by the kidneys.

Paracetamol is rapidly and almost completely absorbed from the gastrointestinal tract.

Plasma concentration peaks after 30-60 minutes.

T1 / 2 plasma-1-4 hours Metabolized in the liver.

Excreted in the urine, mainly in the form of esters with glucuronic and sulfuric acids

less than 5% is excreted unchanged.

Side effects

Allergic reactions (skin rash, angioedema, urticaria), dyspeptic disorders (including nausea, epigastric pain).

In rare cases - hemolytic anemia, thrombocytopenia, methemoglobinemia.

With prolonged use in high doses - hepatotoxicity, pancytopenia, nephrotoxicity (renal colic, pyuria, interstitial nephritis, papillary necrosis).

Selling features

Available without a prescription

Special conditions

Excessive consumption of caffeine-containing products (coffee, tea) during treatment may cause overdose symptoms.

With prolonged (more than 1 week) treatment, it is necessary to control the picture of peripheral blood and the functional state of the liver.

Without consulting a doctor, take no more than 3 days for the treatment of febrile syndrome and no more than 5 days for pain.

May alter the results of athletes' drug testing.

Difficulties in establishing the diagnosis in acute acute abdomen".

Patients suffering from atopic bronchial asthma, hay fever, have an increased risk of developing allergic reactions.

During treatment, you should stop using ethanol (according to

Name ENG

MIGRENIUM

Clinical and pharmacological group

Analgesic antipyretic

ATX code

Paracetamol in combination with psycholeptics

Dosage

65mg + 500mg

Structure

active substances: paracetamol - 0.500 g, caffeine - 0.065 g. auxiliary substances: potato starch, microcrystalline cellulose, croscarmellose sodium, hyprolose (hydroxypropyl cellulose), colloidal silicon dioxide, magnesium stearate, copovidone, talc, titanium dioxide, silicone emulsion (50 % solution).

Indications

Pain syndrome (mild and moderate): headache, migraine, ossalgia, myalgia, neuralgia, arthralgia, algomenorrhea, toothache

febrile syndrome, "colds" diseases, ARVI (including influenza).

Storage conditions and periods

In a dry, dark place at a temperature not exceeding 25 degrees.

Expiration date: 3 years

INN / Active ingredient

paracetamol, caffeine

Contraindications

Hypersensitivity, severe hepatic and / or renal failure, epilepsy, deficiency of glucose-6-phosphate dehydrogenase, old age, children (up to 12 years).

Specifications

Category

Pain relievers

,

Migraine

Scope of the drug

General

Release form

Tablet

Manufacturer country

Russia

Package quantity, pcs

twenty

Minimum age from

12 years

Way of introduction

Through the mouth

Vacation conditions

Without recipe

Brand name

Biochemist

The amount of the dosage form in the primary package

10 pieces.

Primary packaging type

Blister

Type of consumer packaging

Pack of cardboard

Dosage form

Film-coated tablets

The target audience

Children

Expiration date in days

1095

Dosage (volume) of the substance in the preparation

paracetamol - 0.500 g, caffeine - 0.065 g

Package weight, g

twenty

Mode of application

:

Inside, for adults and children after 12 years - 2 tablets 4 times a day with an interval of at least 4 hours. The maximum daily dose is 8 tablets.

Duration of use - no more than 3 days (as an antipyretic) and no more than 5 days (as an analgesic).

Pharmaco-therapeutic group

:

Combined analgesic (non-narcotic analgesic + psychostimulant)

Anatomical and therapeutic characteristics

:

N02BE71 Paracetamol, in combination with psychotropic drugs

Information on technical characteristics, delivery set, country of manufacture "