Midokalm-Richter solution for iv and iv injected 100 mg / ml + 2.5 mg / ml 1 ml ampoules 5 pcs. (Tolperisone, lidocaine)

Latin name

Mydocalm

Release form

Injection.

Packaging

In a dark glass ampoule, 1 ml of solution. In a package of 5 ampoules.

Pharmacological action

MIDOKALM - central muscle relaxant.

The mechanism of action is not fully understood. It has a membrane-stabilizing, local anesthetic effect, inhibits the conductivity of impulses in primary afferent fibers and motor neurons, which leads to blocking of spinal mono- and polysynaptic reflexes.

Also, it is likely that it inhibits the release of neurotransmitters by inhibiting Ca2 + entry into synapses. In the brain stem eliminates the relief of conduction of excitation along the reticulospinal path. Enhances peripheral blood flow regardless of the effect of the central nervous system. In the development of this effect, the weak antispasmodic and adrenoblocking effect of tolperisone plays a role.

Indications

treatment of pathologically increased muscle tone and spasms of striated muscle resulting from organic diseases of the central nervous system (pyramidal tract disease, multiple sclerosis, cerebral stroke, myelopathy, encephalomyelitis)

treatment of increased contractility of the muscle, muscle tone and muscle tone including spondylosis, spondylarthrosis, cervical and lumbar syndromes, arthrosis of large joints)

rehabilitation treatment after orthopedic and traumatological operations

as part of the combination therapy of obliterating vascular diseases (arteriosclerosis obliterans, diabetic angiopathy, thromboangiitis obliterans, Raynaud's disease, diffuse scleroderma), diseases arising from the disorder of vascular innervation and anemorotomy dysbasia)

Little's disease (cerebral palsy) and other encephalopathies accompanied by muscular dystonia her.

Use during pregnancy and lactation

Use during pregnancy, especially in the first trimester, and during lactation (breastfeeding) is possible in cases where the expected benefits of therapy for the mother outweigh the potential risk to the fetus or infant.

Composition

Active ingredients:

tolperizona hydrochloride 100 mg,

lidocaine hydrochloride 2.5 mg

Excipients:

methylparaben,

diethylene monoethylesters,

water d / and

Dosage and administration

Adults are administered intramuscularly at 100 mg 2 times / day or intravenously (slowly) at 100 mg 1 time / day.

Side effects

Muscle weakness, headache, arterial hypotension, nausea, vomiting, abdominal discomfort.

Side effects usually go away with a reduced dose.

In rare cases, allergic reactions (skin itching, erythema, urticaria, angioedema, anaphylactic shock, bronchospasm) are encountered.

No drug interaction

There are no drug interaction data limiting the use of Midocalm-Richter.

Although tolperisone has an effect on the CNS, it does not cause sedation and can therefore be used in combination with sedatives, hypnotics and ethanol-containing drugs.

Does not change the effect of ethanol on the CNS.

Overdose

There is insufficient data on the overdose of the drug Middocalm-Richter.

- Symptoms: the drug has a high therapeutic index, the literature describes the use of the drug in children at a dose of 600 mg without the appearance of serious symptoms of intoxication. In children, ingestion of the drug at a dose of 300-600 mg / day in some cases, irritability was observed.

In experimental animal studies in acute toxicity studies, ataxia, tonic and clonic convulsions, shortness of breath, respiratory paralysis were observed at high doses.

- Treatment: Symptomatic and supportive therapy is recommended. There is no specific antidote.



pharmacy terms of preservation

prescription d14frefp5620 should be used anit in the dark place at a temperature of 8 ° to 15 ° C.

Expiration

3 years.

Deystvuyuschee

Tynydazol substances, Lidocaine



pharmacy terms and conditions for prescription

dosage form

dosage form

solution srlkl drug for solution s18lductp18 sdlkl41

Gedeon Richter Vengriya



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