Metronidazole vaginal suppositories 500 mg 10 pcs. (metronidazole)
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$26.73
Regular Price
$27.00
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SKU
florida493294
Pharmacological action
Pharmaceutical group: antimicrobial and antiprotozoal.
Pharmaceutical action: Antiprotozoal and antibacterial drug derived from 5-nitroimidazole. The mechanism of action is the biochemical reduction of the 5-nitro group of metronidazole by intracellular transport proteins of anaerobic microorganisms and protozoa. The reduced 5-nitro group of metronidazole interacts with the DNA of the cell of microorganisms, inhibiting the synthesis of their nucleic acids, which leads to the death of bacteria.
Active against Trichomonas vaginalis, Entamoeba histolytica, as well as gram-negative anaerobes Bacteroides spp. (including B. fragilis, B. distasonis, B. ovatus, B. thetaiotaomicron, B. vulgatus), Fusobacterium spp. and some gram-positive anaerobes (sensitive strains of Eubacterium spp., Clostridium spp., Peptococcus niger, Peptostreptococcus spp.). The MIC for these strains is 0.125-6.25 Ојg / ml.
Aerobic microorganisms and facultative anaerobes are insensitive to metronidazole, but in the presence of mixed flora (aerobes and anaerobes), metronidazole acts synergistically with antibiotics effective against conventional aerobes.
Pharmacokinetics: After intravaginal administration, it undergoes systemic absorption (about 56%).
The relative bioavailability of the vaginal gel is 2 times higher than the bioavailability of a single dose (500 mg) of vaginal metronidazole tablets.
Penetrates into breast milk and most tissues, passes through the BBB and the placenta. Communication with plasma proteins - less than 20%. It is metabolized in the liver by hydroxylation, oxidation and glucuronidation. The activity of the main metabolite (2-hydroxymetronidazole) is 30% of the activity of the starting compound. TCmax (237 ng / ml) of vaginal gel - 6-12 hours.
Excreted by the kidneys - 60-80% of the dose of the systemic drug (20% of this amount unchanged), intestines - 6-15% of the dose of a systemic drug. Buy Metronidazole vaginal suppositories 500 mg 10 pcs. (metronidazole) in florida free shipping. Fast international shipping USA, AU, EU, UK and others.
Pharmaceutical group: antimicrobial and antiprotozoal.
Pharmaceutical action: Antiprotozoal and antibacterial drug derived from 5-nitroimidazole. The mechanism of action is the biochemical reduction of the 5-nitro group of metronidazole by intracellular transport proteins of anaerobic microorganisms and protozoa. The reduced 5-nitro group of metronidazole interacts with the DNA of the cell of microorganisms, inhibiting the synthesis of their nucleic acids, which leads to the death of bacteria.
Active against Trichomonas vaginalis, Entamoeba histolytica, as well as gram-negative anaerobes Bacteroides spp. (including B. fragilis, B. distasonis, B. ovatus, B. thetaiotaomicron, B. vulgatus), Fusobacterium spp. and some gram-positive anaerobes (sensitive strains of Eubacterium spp., Clostridium spp., Peptococcus niger, Peptostreptococcus spp.). The MIC for these strains is 0.125-6.25 Ојg / ml.
Aerobic microorganisms and facultative anaerobes are insensitive to metronidazole, but in the presence of mixed flora (aerobes and anaerobes), metronidazole acts synergistically with antibiotics effective against conventional aerobes.
Pharmacokinetics: After intravaginal administration, it undergoes systemic absorption (about 56%).
The relative bioavailability of the vaginal gel is 2 times higher than the bioavailability of a single dose (500 mg) of vaginal metronidazole tablets.
Penetrates into breast milk and most tissues, passes through the BBB and the placenta. Communication with plasma proteins - less than 20%. It is metabolized in the liver by hydroxylation, oxidation and glucuronidation. The activity of the main metabolite (2-hydroxymetronidazole) is 30% of the activity of the starting compound. TCmax (237 ng / ml) of vaginal gel - 6-12 hours.
Excreted by the kidneys - 60-80% of the dose of the systemic drug (20% of this amount unchanged), intestines - 6-15% of the dose of a systemic drug. Buy Metronidazole vaginal suppositories 500 mg 10 pcs. (metronidazole) in florida free shipping. Fast international shipping USA, AU, EU, UK and others.
Pharmacological action
Pharmaceutical group: antimicrobial and antiprotozoal.
Pharmaceutical action: Antiprotozoal and antibacterial drug derived from 5-nitroimidazole. The mechanism of action is the biochemical reduction of the 5-nitro group of metronidazole by intracellular transport proteins of anaerobic microorganisms and protozoa. The reduced 5-nitro group of metronidazole interacts with the DNA of the cell of microorganisms, inhibiting the synthesis of their nucleic acids, which leads to the death of bacteria.
Active against Trichomonas vaginalis, Entamoeba histolytica, as well as gram-negative anaerobes Bacteroides spp. (including B. fragilis, B. distasonis, B. ovatus, B. thetaiotaomicron, B. vulgatus), Fusobacterium spp. and some gram-positive anaerobes (sensitive strains of Eubacterium spp., Clostridium spp., Peptococcus niger, Peptostreptococcus spp.). The MIC for these strains is 0.125-6.25 Ојg / ml.
Aerobic microorganisms and facultative anaerobes are insensitive to metronidazole, but in the presence of mixed flora (aerobes and anaerobes), metronidazole acts synergistically with antibiotics effective against conventional aerobes.
Pharmacokinetics: After intravaginal administration, it undergoes systemic absorption (about 56%).
The relative bioavailability of the vaginal gel is 2 times higher than the bioavailability of a single dose (500 mg) of vaginal metronidazole tablets.
Penetrates into breast milk and most tissues, passes through the BBB and the placenta. Communication with plasma proteins - less than 20%. It is metabolized in the liver by hydroxylation, oxidation and glucuronidation. The activity of the main metabolite (2-hydroxymetronidazole) is 30% of the activity of the starting compound. TCmax (237 ng / ml) of vaginal gel - 6-12 hours.
Excreted by the kidneys - 60-80% of the dose of the systemic drug (20% of this amount unchanged), intestines - 6-15% of the dose of a systemic drug.
Indications
Urogenital trichomoniasis (including urethritis, vaginitis), nonspecific vaginitis of various etiologies, confirmed by clinical and microbiological data.
Contraindications
Hypersensitivity (including derivatives of nitroimidazole), leukopenia, impaired coordination of movements, organic CNS lesions (including epilepsy), liver failure (in case of high doses), pregnancy (I trimester), lactation period.
Caution. Pregnancy (II-III trimesters), a history of leukopenia.
Dosage and Administration
Intravaginally, once 2 g or in the form of a course of treatment at 500 mg / day 2 times a day (morning and evening) for 10 days.
During treatment, sexual intercourse should be avoided.
Side effects
Allergic reactions: urticaria, skin rash.
Local reactions: burning sensation or irritation of the penis in the sexual partner, burning sensation or rapid urination, vulvitis (itching, burning pain or hyperemia of the mucous membrane in the external genital area).
Systemic effects may develop: a change in taste, including a metallic taste, dizziness, headache, dry oral mucosa, nausea, vomiting, decreased appetite, spastic abdominal pain, constipation or diarrhea, dark urine, leukopenia, or leukocytosis.
After discontinuation of the drug - the development of vaginal candidiasis.
Drug Interactions
Similar to disulfiram, it causes ethanol intolerance.
Concomitant use with disulfiram can lead to the development of various neurological symptoms (metronidazole should not be prescribed to patients who have taken disulfiram for the last 2 weeks).
Enhances the effect of indirect anticoagulants (warfarin), it is not recommended to combine with non-depolarizing muscle relaxants (vecuronium bromide).
With simultaneous administration with Li + preparations, the concentration of the latter in plasma may increase.
Phenobarbital accelerates the metabolism of metronidazole due to the induction of microsomal liver enzymes cimetidine - reduces, which can lead to an increase in its concentration in the blood serum and an increased risk of side effects.
Overdose of
Symptoms: nausea, vomiting, ataxia.
Treatment: no specific antidote, symptomatic and supportive therapy.
active substance
Metronidazole
Terms of delivery from
pharmacies Prescription
dosage form
vaginal suppositories nye
Appointment
Pregnant II and III trimester by doctor's appointment, Adult by doctor's appointment
Indications
That vaginitis, From inflammation of female genital organs
Anzhero-HFZ, Russia
Metronidazole vaginal suppositories 500 mg 10 pcs. (metronidazole) florida in pharmacy online. Cheap price, instruction, side effects, dosage. Metronidazole vaginal suppositories 500 mg 10 pcs. - Sale. PayPal accept. Free shipping florida. Fast international shipping.
Pharmaceutical group: antimicrobial and antiprotozoal.
Pharmaceutical action: Antiprotozoal and antibacterial drug derived from 5-nitroimidazole. The mechanism of action is the biochemical reduction of the 5-nitro group of metronidazole by intracellular transport proteins of anaerobic microorganisms and protozoa. The reduced 5-nitro group of metronidazole interacts with the DNA of the cell of microorganisms, inhibiting the synthesis of their nucleic acids, which leads to the death of bacteria.
Active against Trichomonas vaginalis, Entamoeba histolytica, as well as gram-negative anaerobes Bacteroides spp. (including B. fragilis, B. distasonis, B. ovatus, B. thetaiotaomicron, B. vulgatus), Fusobacterium spp. and some gram-positive anaerobes (sensitive strains of Eubacterium spp., Clostridium spp., Peptococcus niger, Peptostreptococcus spp.). The MIC for these strains is 0.125-6.25 Ојg / ml.
Aerobic microorganisms and facultative anaerobes are insensitive to metronidazole, but in the presence of mixed flora (aerobes and anaerobes), metronidazole acts synergistically with antibiotics effective against conventional aerobes.
Pharmacokinetics: After intravaginal administration, it undergoes systemic absorption (about 56%).
The relative bioavailability of the vaginal gel is 2 times higher than the bioavailability of a single dose (500 mg) of vaginal metronidazole tablets.
Penetrates into breast milk and most tissues, passes through the BBB and the placenta. Communication with plasma proteins - less than 20%. It is metabolized in the liver by hydroxylation, oxidation and glucuronidation. The activity of the main metabolite (2-hydroxymetronidazole) is 30% of the activity of the starting compound. TCmax (237 ng / ml) of vaginal gel - 6-12 hours.
Excreted by the kidneys - 60-80% of the dose of the systemic drug (20% of this amount unchanged), intestines - 6-15% of the dose of a systemic drug.
Indications
Urogenital trichomoniasis (including urethritis, vaginitis), nonspecific vaginitis of various etiologies, confirmed by clinical and microbiological data.
Contraindications
Hypersensitivity (including derivatives of nitroimidazole), leukopenia, impaired coordination of movements, organic CNS lesions (including epilepsy), liver failure (in case of high doses), pregnancy (I trimester), lactation period.
Caution. Pregnancy (II-III trimesters), a history of leukopenia.
Dosage and Administration
Intravaginally, once 2 g or in the form of a course of treatment at 500 mg / day 2 times a day (morning and evening) for 10 days.
During treatment, sexual intercourse should be avoided.
Side effects
Allergic reactions: urticaria, skin rash.
Local reactions: burning sensation or irritation of the penis in the sexual partner, burning sensation or rapid urination, vulvitis (itching, burning pain or hyperemia of the mucous membrane in the external genital area).
Systemic effects may develop: a change in taste, including a metallic taste, dizziness, headache, dry oral mucosa, nausea, vomiting, decreased appetite, spastic abdominal pain, constipation or diarrhea, dark urine, leukopenia, or leukocytosis.
After discontinuation of the drug - the development of vaginal candidiasis.
Drug Interactions
Similar to disulfiram, it causes ethanol intolerance.
Concomitant use with disulfiram can lead to the development of various neurological symptoms (metronidazole should not be prescribed to patients who have taken disulfiram for the last 2 weeks).
Enhances the effect of indirect anticoagulants (warfarin), it is not recommended to combine with non-depolarizing muscle relaxants (vecuronium bromide).
With simultaneous administration with Li + preparations, the concentration of the latter in plasma may increase.
Phenobarbital accelerates the metabolism of metronidazole due to the induction of microsomal liver enzymes cimetidine - reduces, which can lead to an increase in its concentration in the blood serum and an increased risk of side effects.
Overdose of
Symptoms: nausea, vomiting, ataxia.
Treatment: no specific antidote, symptomatic and supportive therapy.
active substance
Metronidazole
Terms of delivery from
pharmacies Prescription
dosage form
vaginal suppositories nye
Appointment
Pregnant II and III trimester by doctor's appointment, Adult by doctor's appointment
Indications
That vaginitis, From inflammation of female genital organs
Anzhero-HFZ, Russia
Metronidazole vaginal suppositories 500 mg 10 pcs. (metronidazole) florida in pharmacy online. Cheap price, instruction, side effects, dosage. Metronidazole vaginal suppositories 500 mg 10 pcs. - Sale. PayPal accept. Free shipping florida. Fast international shipping.
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