Mesatone ampoules 1%, 1 ml, 10 pcs. (phenylephrine)

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Release form

Injection. Buy Mesatone ampoules 1%, 1 ml, 10 pcs. (phenylephrine) in florida free shipping. Fast international shipping USA, AU, EU, UK and others.
Release form

Injection.

Packing

10 pcs.

Pharmacological action

Adrenomimetic. It has a direct stimulating effect mainly on -Adrenoreceptors.

With systemic use, it causes narrowing of arterioles, increases OPSS and blood pressure. Cardiac output does not change or decreases, which is associated with reflex bradycardia (an increase in the tone of the vagus nerve) in response to arterial hypertension. Phenylephrine does not increase blood pressure as dramatically as norepinephrine and epinephrine, but it lasts longer. This, apparently, is due to the fact that phenylephrine is more stable and does not collapse under the influence of COMT.

When applied topically, phenylephrine has a pronounced vasoconstrictor effect, causes mydriasis, can lower intraocular pressure with open-angle glaucoma.

At moderate therapeutic doses, virtually no effect on the central nervous system.

Indications

Inside and topical: to reduce swelling of the mucous membrane of the nasopharynx, conjunctiva for colds and allergies (mainly as part of combination preparations).

Parenteral: to increase blood pressure during collapse and arterial hypotension due to a decrease in vascular tone.

Contraindications

Arterial hypertension, severe atherosclerosis, tendency to spasm of coronary vessels, hypersensitivity to phenylephrine.

Special instructions

The use of phenylephrine in patients with severe hyperthyroidism should be avoided.

Use with caution in CHD.

When applied topically after absorption through the mucous membrane, phenylephrine can cause systemic effects. In this regard, the use of phenylephrine in the form of 10% eye drops in infants and elderly patients should be avoided.

Composition

Active ingredient: phenylephrine hydrochloride 10 mg

Excipients: glycerin water for injection

Dosage and administration of

When administered orally and topically, the dose depends on the indications and the dosage form used.

With the introduction of sc or i / m, a single dose is 2-5 mg, then, if necessary, 1-10 mg. With the on / in the introduction of jet (slowly) a single dose is 100-500 mcg. With IV infusion, the initial rate is 180 mcg / min. further, depending on the effect, it is reduced to 30-60 mcg / min.

Maximum doses: for adults, when taken orally, a single dose - 30 mg, daily - 150 mg sc or i / m single dose - 10 mg, daily - 50 mg with iv single dose 5 mg, daily - 25 mg .

Side effects of

From the cardiovascular system: undesirable long-term increase in blood pressure, tachycardia or reflex bradycardia are possible.

Local reactions: possibly irritating to the mucous membranes.

Drug Interactions

When using phenylephrine against the background of general anesthesia caused by halothane or cyclopropane, ventricular fibrillation may develop.

With simultaneous use with MAO inhibitors, potentiation of the effects of phenylephrine is observed (including with topical application).

Phenothiazines, alpha-blockers (phentolamine), furosemide and other diuretics reduce the vasoconstrictor effect of phenylephrine.

Guanethidine enhances the mydriatic effect of phenylephrine (with systemic absorption).

Oxytocin, ergot alkaloids, tricyclic antidepressants, furazolidone, procarbazine, selegiline, sympathomimetics enhance the pressor effect, and the latter increase arrhythmogenicity.

With the simultaneous use of beta-blockers reduce pacemaker activity against the background of reserpine, arterial hypertension is possible (due to depletion of catecholamines in adrenergic neurons, sensitivity to sympathomimetics increases).

Overdose

Manifested by ventricular extrasystole and short paroxysms of ventricular tachycardia, a feeling of heaviness in the head and limbs, a significant increase in blood pressure.

Treatment: iv administration of alpha-blockers (e.g. phentolamine) and beta-blockers (for rhythm disturbances).

Storage Conditions

In a dark place at a temperature not exceeding 25 ° C.

Expiration

3 years.

Active ingredient

Phenylephrine

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