Melaxen tab. p / o 3mg No. 24

Dosage form

Film-coated tablets

Structure

melatonin 3 mg

Excipients: dibasic calcium phosphate, microcrystalline cellulose, magnesium stearate, talc, pharmaceutical glaze, isopropyl alcohol.

pharmachologic effect

An adaptogenic drug, a chemical analogue of the biogenic amine melatonin.

Synthesized from amino acids of plant origin.

Chemical formula N-acetyl-5-methoxytryptamine, molecular weight 232. Soluble in water, alcohol, lipids.

It is a synthetic analogue of the pineal gland hormone.

Normalizes circadian rhythms.

Regulates the sleep-wake cycle, daily changes in motor activity and body temperature.

Contributes to the normalization of night sleep: accelerates falling asleep, improves sleep quality, reduces the number of night awakenings, improves well-being after waking up in the morning, does not cause feelings of lethargy, weakness and fatigue upon awakening, dreams become more vivid and emotionally saturated.

The body adapts to the rapid change of time zones, reduces stress reactions.

Shows immunostimulating and pronounced antioxidant properties.

It inhibits the secretion of gonadotropins and, to a lesser extent, other hormones of the adenohypophysis (corticotropin, thyrotropin and somatotropin).

It is not addictive and addictive.

Pharmacokinetics

When taken orally, it is quickly and completely absorbed, it easily passes histohematogenous barriers, including the BBB.

Has a short T1 / 2.

Side effects

From the side of the central nervous system: headache, morning sleepiness.

From the digestive system: nausea, vomiting, diarrhea.

Others: allergic reactions to the components of the drug

swelling in the first week of admission.

Selling features

Available without a prescription

Special conditions

It is necessary to inform women wishing to become pregnant about the presence of a weak contraceptive effect in the drug.

During the period of use of the drug, avoid exposure to bright light.

Influence on the ability to drive vehicles and use mechanisms

During the period of treatment, it is necessary to refrain from driving vehicles and other activities with potentially hazardous activities that require increased concentration of attention and speed of psychomotor reactions.

Indications

- as a sleeping pill

- as an adaptogen for the normalization of biological rhythms

Contraindications

- severe renal dysfunction

- autoimmune diseases

- leukemia

- lymphoma

- allergic reactions

- lymphogranulomatosis

- myeloma

- epilepsy

- diabetes

- chronic renal failure

- pregnancy

- lactation period (breastfeeding)

- hypersensitivity to the drug.

Drug interactions

With the simultaneous use of melatonin enhances the effect of drugs that have a depressing effect on the central nervous system, and beta-blockers.

It is not recommended to be taken together with hormonal drugs.

Not compatible with MAO inhibitors, GCS and cyclosporine.

Dosage

Adults are prescribed 1 / 2-1 tablets 1 time / 30-40 minutes before bedtime.

When used as an adaptogen when changing time zones 1 day before the flight and in the next 2-5 days - 1 tablet 30-40 minutes before bedtime.

The maximum daily dose is up to 2 tablets

Overdose

increased severity of side effects

Name ENG

MELAXEN

Clinical and pharmacological group

Adaptogenic drug

ATX code

Melatonin

Dosage

3mg

Structure

melatonin 3 mg.

Excipients: dibasic calcium phosphate, microcrystalline cellulose, magnesium stearate, talc, pharmaceutical glaze, isopropyl alcohol.

INN / Active ingredient

Melatonin

Storage conditions and periods

In a dry, dark place at a temperature of 10-30 degrees.

Expiration date: 4 years

Specifications

Category

Sedatives

,

Antipsychotics

,

Neurological disorders

Scope of the drug

Vitamins

Release form

Tablet

Manufacturer country

USA

Package quantity, pcs

24

Scope of application

Immunology

Way of introduction

Through the mouth

Vacation conditions

Without recipe

Brand name

Unipharm

The amount of the dosage form in the primary package

12 pcs.

Primary packaging type

Blister

Type of consumer packaging

Pack of cardboard

Pharmaco-therapeutic group

Adaptogenic agent

Anatomical and therapeutic characteristics

N05CH01 Melatonin

Dosage form

Film-coated tablets

Expiration date in days

1461

Dosage (volume) of the substance in the preparation

melatonin 3 mg

Package weight, g

15

Mode of application

:

Adults are prescribed 1 / 2-1 tablets 1 time / day 30-40 minutes before bedtime.

When used as an adaptogen when changing time zones 1 day before the flight and in the next 2-5 days - 1 tablet 30-40 minutes before bedtime.

The maximum daily dose is up to 2 tablets.