Magne B6 forte tablets coated.pl.ob. 30 pcs (Pyridoxine)

Latin name

Magne B6 forte

Release form

Coated tablets.

Packing

In a pack of 30 tablets.

Pharmacological action

Magnesium is a vital element that is necessary for the normal functioning of cells, is involved in most metabolic reactions. In particular, it is involved in the regulation of transmission of nerve impulses and in muscle contraction. 1/3 of the amount of magnesium in the body accumulates in the bone tissue. The body receives magnesium along with food. A lack of magnesium in the body can be observed with a violation of the diet (diet) or with an increase in the need for magnesium.

Pyridoxine (Vitamin B6) is involved in many metabolic processes and helps to improve the absorption of magnesium from the gastrointestinal tract and its penetration into cells.

Serum magnesium levels:

between 12 and 17 mg / L (1 - 1.4 mEq / L or 0.5 - 0.7 mmol / L): indicate a moderate magnesium deficiency of

below 12 mg / L (1 mEq / l or 0.5 mmol / l): indicate a severe magnesium deficiency.

Pharmacokinetics

Gastrointestinal absorption of magnesium salts occurs in part by a passive mechanism in which salt solubility plays a decisive role. The degree of this absorption does not exceed 50%. Excretion occurs mainly by the kidneys.

Indications

Established magnesium deficiency, isolated or associated with other deficient conditions, accompanied by symptoms such as: - Increased irritability.

- Minor sleep disturbances.

- Gastrointestinal cramping.

- Heart palpitations.

- Fatigue.

- Pain and muscle cramps.

- Tingling sensation in the muscles.

If, after a month of treatment, there is no reduction in these symptoms, continued treatment is not practical.

Contraindications

- Hypersensitivity to any component of the drug.

- Severe renal failure (creatinine clearance less than 30 ml / min).

- Phenylketonuria.

- Age up to 6 years (efficacy and safety not established).

- Hereditary galactosemia, glucose and galactose malabsorption syndrome or lactase deficiency (due to the presence of lactose in the preparation).

- Concurrent administration of levodopa.

Precautions: moderate renal failure (danger of developing hypermagnesemia).

Use during pregnancy and lactation

During pregnancy, the drug is taken only on the recommendation of a doctor.

Whereas magnesium passes into breast milk, if necessary, it is recommended to stop breastfeeding.

Composition

In 1 film-coated tablet contains: magnesium citrate 618.43 mg, pyridoxine hydrochloride 10 mg.

Excipients: lactose, macrogol-6000, magnesium stearate, hypromellose 5mPa.s, titanium dioxide (E 171), talc.

Dosage and administration

Tablets should be taken whole with a glass of water.

Adults: 3-4 tablets per day, divided into 2-3 doses, with meals.

For children over the age of 6 years (weighing about 20 kg): 10-30 mg / kg / day (04-1.2 mmol / kg / day), that is, 2-4 tablets per day, divided into 2-3 doses, with meals.

Typically, the duration of treatment is 1 month.

Side effects of

Immune system disorders: allergic reactions, including skin reactions

Gastrointestinal disorders: diarrhea, abdominal pain, nausea, vomiting, flatulence.

Drug Interaction

Contraindications with levodopa: levodopa activity (if this drug is not combined with peripheral dopadecarboxylase inhibitors) is inhibited by pyridoxine. Any use of pyridoxine should be avoided unless peripheral dopamine decarboxylase inhibitors are administered concomitantly with levodopa.

Concomitant administration of preparations containing phosphates or calcium salts can significantly reduce the absorption of magnesium in the gastrointestinal tract. With phosphate or calcium salts: these products inhibit intestinal absorption of magnesium.

When administered inside tetracyclines, an interval of at least 3 hours must be observed between ingestion of tetracyclines and magnesium, as magnesium reduces the gastrointestinal absorption of tetracyclines.

Overdose

With normal kidney function, magnesium intake does not cause toxic reactions. However, in the case of kidney failure, the development of magnesium poisoning is possible. The severity of overdose symptoms depends on the concentration of magnesium in the blood.

Symptoms: decreased blood pressure, nausea, vomiting, central nervous system depression, decreased reflexes, changes in electrocardiogram (reduction and / or disturbances of rhythm of the heart), respiratory depression, coma, cardiac arrest and respiratory paralysis, anuria.

Treatment: rehydration, forced diuresis. Renal insufficiency requires hemodialysis or peritoneal dialysis.

Storage conditions

Store at a temperature not exceeding 30 ° C

Expiration

2 years.



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dosage form

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tablets

Sano i-Aventis, France



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