Loperamide-Akrihin caps. 2mg 20 pcs

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SKU
FL102050
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Category

Diarrhea

,

Preparations for the gastrointestinal tract

Scope of the drug

Gastrointestinal tract

Release form

Capsules

Manufacturer country

Russia

Package quantity, pcs

twenty

Description

Release form, composition and packaging

Yellow capsules, size 4

the contents of the capsules are white or white with a yellowish sheen powder.

1 caps.

loperamide hydrochloride

2 mg

lactose monohydrate - 104.5 mg, corn starch - 30 mg, colloidal silicon dioxide - 0.7 mg, talc - 1.4 mg, magnesium stearate - 1.4 mg.

The composition of the capsule shell: hard gelatin capsule (titanium dioxide - 1.3333%, quinoline yellow dye - 0.9197%, sunset yellow dye - 0.0044%, gelatin - up to 100%) - 38 mg.

10 pieces.

- contour cell packaging (1) - cardboard packs.

10 pieces.

- contour cell packages (2) - cardboard packs.

pharmachologic effect

Loperamide, binding to opioid receptors of the intestinal wall (stimulation of choline and adrenergic neurons through guanine nucleotides), reduces the tone and motility of intestinal smooth muscles (by inhibiting the release of acetylcholine and prostaglandins).

Slows down peristalsis and increases the transit time of intestinal contents.

Increases the tone of the anal sphincter, helps to retain stool and reduce the urge to defecate.

The action develops quickly and lasts 4-6 hours.

Pharmacokinetics

Oral absorption is 40%.

Cmax in plasma is reached 2.5 hours after taking the capsules.

Communication with plasma proteins (mainly albumin) - 97%.

Does not penetrate the BBB.

Almost completely metabolized by the liver by conjugation.

T1 / 2 - 9-14 hours (average 9.8 hours).

It is excreted mainly with bile, a small part is excreted by the kidneys (in the form of conjugated metabolites).

Indications for use

symptomatic treatment of acute and chronic diarrhea of ��various origins (allergic, emotional, drug, radiation)

with a change in the diet and the qualitative composition of food, with metabolic and absorption disorders

as an adjuvant for infectious diarrhea

regulation of stool in patients with ileostomy.

Contraindications for use

hypersensitivity

intestinal obstruction,

acute ulcerative colitis,

diverticulosis,

diarrhea against the background of acute pseudomembranous enterocolitis, dysentery and other gastrointestinal infections.

pregnancy (1 trimester),

lactation period,

children under 2 years of age (Loperamide-Acri capsules are not prescribed for children under 6 years of age).

With caution: liver failure.

Dosage regimen

Inside, without chewing, drinking water.

Adults with acute diarrhea are initially prescribed 2 caps.

(4 mg) Loperamide-Acri, then - 1 caps.

(With 2 mg) after each bowel movement in case of loose stools.

The highest daily dose is 8 caps.

(With 16 mg).

For chronic diarrhea, adults are prescribed 4 mg / day.

The maximum daily dose is 16 mg.

For acute diarrhea, children over 6 years of age are prescribed an initial dose of 2 mg, then 2 mg after each act of defecation in the case of loose stools.

The maximum daily dose is 4 caps.

(With 8 mg).

For chronic diarrhea, children over 6 years of age are prescribed Loperamide-Acri in a daily dose of 2 mg.

The maximum daily dose is 6 mg per 20 kg.

After stool normalization or in the absence of stool for more than 12 hours, the drug should be discontinued.

Overdose

Symptoms: signs of depression of the central nervous system (stupor, impaired coordination of movements, drowsiness, constriction of the pupils (miosis), increased skeletal muscle tone, respiratory depression), intestinal obstruction.

Treatment: Naloxone is used as a specific antidote.

Given that the duration of action of Loperamide-Acri is longer than that of naloxone, it is possible to re-introduce the latter.

Symptomatic treatment: gastric lavage, intake of activated charcoal (in the first 3 hours after taking the drug), artificial ventilation.

Side effect

It is observed, as a rule, only with prolonged use of the drug.

Allergic reactions (skin rash), drowsiness, dizziness, hypovolemia, electrolyte disturbances, dry mouth, intestinal colic, gastralgia, abdominal pain or discomfort, nausea, vomiting, flatulence are possible.

Rarely - urinary retention

extremely rare - intestinal obstruction.

Application during pregnancy and lactation

The drug is contraindicated in the first trimester of pregnancy, and during lactation.

Special instructions If there is no effect after 2 days of using Loperamide-AcriВ®, it is necessary to clarify the diagnosis and exclude the infectious genesis of diarrhea.

Children under 6 years of age are not recommended to prescribe the drug in the form of capsules.

If constipation or bloating develops during treatment, Loperamide-Acri should be canceled.

In patients with impaired liver function, careful monitoring of signs of toxic damage to the central nervous system is necessary.

During the period of diarrhea treatment, it is necessary to replenish the loss of fluids and electrolytes.

Influence on the ability to drive vehicles and use mechanisms

During treatment, care must be taken when driving vehicles and engaging in other potentially hazardous activities that require increased concentration of attention and speed of psychomotor reactions.

Name ENG

LOPERAMIDE-AKRIKHIN

Clinical and pharmacological group

Antidiarrheal symptomatic drug.

ATX code

Loperamide

Dosage

2mg

Structure

Active ingredient: loperamide hydrochloride 2 mg Excipients: corn starch

milk sugar

talc

aerosil

magnesium stearate.

Indications

Symptomatic treatment of acute and chronic diarrhea of ��various origins (including allergic, emotional, medicinal, radiation with a change in diet and quality composition of food, with metabolic and absorption disorders as an adjunct for infectious diarrhea).

Stool regulation in patients with ileostomy.

Contraindications

Hypersensitivity, intestinal obstruction, diverticulosis, acute ulcerative colitis, pseudomembranous colitis caused by taking broad-spectrum antibiotics

other conditions in which suppression of intestinal peristalsis is unacceptable

acute dysentery (especially with the presence of blood in the stool and accompanied by an increased body temperature)

children's age (up to 2 years).

Storage conditions and periods

In a dry place, at a temperature not exceeding 25 degrees, in the original packaging.

Expiration date: 4 years

INN / Active ingredient

Loperamide

Specifications

Category

Diarrhea

,

Preparations for the gastrointestinal tract

Scope of the drug

Gastrointestinal tract

Release form

Capsules

Manufacturer country

Russia

Package quantity, pcs

twenty

Way of introduction

Through the mouth

Vacation conditions

Without recipe

Brand name

Akrikhin

The amount of the dosage form in the primary package

10 pieces.

Primary packaging type

Blister

Type of consumer packaging

Pack of cardboard

Pharmaco-therapeutic group

Antidiarrheal agent

Anatomical and therapeutic characteristics

A07DA03 Loperamide

Dosage form

Capsules

Dosage (volume) of the substance in the preparation

loperamide hydrochloride 2 mg

The target audience

Adult

Expiration date in days

1460

Package weight, g

twenty

Mode of application

:

Inside. < br> < br> Acute diarrhea.

Adults: the initial dose is 4 mg, then 2 mg after each act of defecation with loose stools.

Children over 5 years of age: the initial dose is 2 mg, then 2 mg after each act of defecation with loose stools. < br> < br> Chronic diarrhea.

Adults: the initial dose is 4 mg, then 2 mg 1-6 times a day.

Children over 5 years of age: 2 mg 1�5 times a day.

Information on technical characteristics, delivery set, country of manufacture

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