Libexin Muko syrup 5% fl. 125ml
Category
Thinning phlegm
,
Expectorants
Scope of the drug
Respiratory system
Release form
Syrup
Manufacturer country
Germany
Package quantity, pcs
one
Structure
Active ingredient: carbocisteine ��5 g
Excipients: sucrose - 40 g
methyl parahydroxybenzoate - 0.15 g
caramel dye, powder (E150) - 0.0344 g
cinnamon oil - 0.002 g
aromatic elixir (ethyl alcohol - 55.3%, rum - 42.7%, rum aromatic additive - 2.0%) - 2 ml
sodium hydroxide - qs to pH 6.1�6.3
purified water - up to 100 ml
pharmachologic effect
Carbocisteine, being a mucolytic, has an effect on the gel phase of endobronchial secretion, breaking the disulfide bridges of glycoproteins and, thus, reducing the viscosity and increasing the elasticity of the secretion.
Carbocisteine ��activates sial transferase - an enzyme of the goblet cells of the bronchial mucosa, normalizes the quantitative ratio of acidic and neutral sialomucins, promotes the regeneration of the mucous membrane, normalizes its structure, activates the activity of the ciliated epithelium, restores the secretion of immunologically active IgA (specific protection), improves mucociliary clearance.
Pharmacokinetics
Carbocisteine ��is rapidly absorbed after oral administration, reaching Cmax levels in serum after 2 hours. Bioavailability is low (less than 10% of the dose taken) as a result of possible rapid passage through the liver.
T1 / 2 about 2 hours. It is excreted mainly by the kidneys along with metabolites.
Indications
Tracheitis, bronchitis, tracheobronchitis, bronchial asthma, bronchiectasis, inflammatory diseases of the middle ear, nose and its paranasal sinuses - rhinitis, otitis media, sinusitis
preparation of the patient for bronchoscopy or bronchography.
Contraindications
peptic ulcer of the stomach and duodenum in the acute stage
chronic glomeruphritis (in the acute phase), cystitis
pregnancy
children under 2 years old
hypersensitivity to carbocisteine ��or other components of the drug.
With care, history of gastric ulcer and duodenal ulcer, lactation period.
Side effects
From the digestive tract: sometimes - nausea, vomiting, diarrhea, epigastric pain, gastrointestinal bleeding.
From the immune system: allergic skin rash and anaphylactic reactions, including urticaria, angioedema, exanthema, persistent drug erythema.
From the skin and subcutaneous tissues: isolated cases of bullous dermatitis, including Stevens-Johnson syndrome and erythema multiforme (exudative).
Allergic reactions: itching, urticaria, exanthema, angioedema.
Others: dizziness, weakness, malaise.
Interaction
Carbocisteine ��increases the effectiveness of GCS and antibacterial therapy of inflammatory diseases of the upper and lower respiratory tract, potentiates the bronchodilator effect of theophylline.
The activity of carbocisteine ��is weakened by antitussives and atropine-like drugs.
Due to the alcohol content, Libeksin MukoВ® (for adults) is prescribed with caution with the following drugs: drugs that cause adverse reactions (fever, redness, vomiting, tachycardia) while taking with alcoholic beverages - disulfiram, cefamandol, cefoperazone, latamoxef (cephalosporin antibiotics ), chloramphenicol (a phenicol antibiotic), chlorpropamide, glibenclamide, glipizide, tolbutamide (sulfa antidiabetic drugs), griseofulvin (an antifungal drug), nitro-5-imidazoles (metronidazole, ornidazole, secnidazol), tinidocarcinol), tinidocarzol
drugs that depress the central nervous system.
How to take, course of administration and dosage
Inside.
One measuring cup of syrup (15 ml) contains 750 mg of carbocysteine, 1 scoop (5 ml) contains 100 mg of carbocysteine.
Adults - one measuring cup (15 ml) 3 times a day, preferably separately from meals
children 2�5 years old - 1 measuring spoon 2 times a day (200 mg / day), over 5 years old - 1 measuring spoon 3 times a day (300 mg / day).
Duration of treatment without
Name ENG
LIBEXIN MUCO
Clinical and pharmacological group
Mucolytic drug
ATX code
Carbocisteine
Dosage
50mg / ml x 125ml
Structure
Active ingredient: carbocisteine ��5 g
Excipients: sucrose - 40 g
methyl parahydroxybenzoate - 0.15 g
caramel dye, powder (E150) - 0.0344 g
cinnamon oil - 0.002 g
aromatic elixir (ethyl alcohol - 55.3%, rum - 42.7%, rum aromatic additive - 2.0%) - 2 ml
sodium hydroxide - qs to pH 6.1�6.3
purified water - up to 100 ml.
Indications
Tracheitis, bronchitis, tracheobronchitis, bronchial asthma, bronchiectasis, inflammatory diseases of the middle ear, nose and sinuses rhinitis, otitis media, sinusitis
preparation of the patient for bronchoscopy or bronchography.
Storage conditions and periods
At a temperature not higher than 25 degrees.
Expiration date: 3 years
INN / Active ingredient
Carbocisteine
Contraindications
peptic ulcer of the stomach and duodenum in the acute stage
chronic glomeruphritis (in the acute phase), cystitis
pregnancy
children under 15 years old
, hypersensitivity to carbocisteine ��or other components of the drug.
With care, history of gastric ulcer and duodenal ulcer, lactation period.
Specifications
Category
Thinning phlegm
,
Expectorants
Scope of the drug
Respiratory system
Release form
Syrup
Manufacturer country
Germany
Package quantity, pcs
one
Scope of application
Virology
Minimum age from
15 years
Way of introduction
Through the mouth
Vacation conditions
Without recipe
Volume, ml.
25 ml
Brand name
A. Nattermann and Cie.
Components
measuring glass
The amount of the dosage form in the primary package
125 ml
Primary packaging type
Bottle
Type of consumer packaging
Pack of cardboard
Pharmaco-therapeutic group
Expectorant mucolytic agent
Anatomical and therapeutic characteristics
R05CB03 Carbocisteine
Dosage form
Syrup
The target audience
Children
Expiration date in days
1095
Package weight, g
255
Mode of application
:
One measuring cup of syrup (15 ml) contains 750 mg of carbocysteine, 1 scoop (5 ml) contains 100 mg of carbocysteine.
Adults - one measuring cup (15 ml) 3 times a day, preferably separately from meals
children 2�5 years old - 1 measuring spoon 2 times a day (200 mg / day), over 5 years old - 1 measuring spoon 3 times a day (300 mg / day).
Information on technical characteristics, delivery set, country of manufacture