Libexin Muco syrup 50 mg / ml 125 ml (Carbocysteine)

Latin name

Libexin muco

Release form

Syrup

Packing

Bottle 125 ml.

Pharmacological action

carbocysteine, being a mucolytic, it acts on the gel phase of the endobronchial secretion, breaking the disulfide bridges of glycoproteins and, thus, reducing viscosity and increasing the elasticity of the secretion.

Carbocysteine ​​activates sialic transferase, an enzyme of goblet cells of the bronchial mucosa, normalizes the quantitative ratio of acid and neutral sialomucins, promotes the regeneration of the mucous membrane, normalizes its structure, activates the activity of ciliary epithelium, restores the secretion of immunologically active IgA (specific protection), improves mucocytes.

Pharmacokinetics

Carbocysteine ​​is rapidly absorbed after oral administration, reaching a maximum level in serum after 2 hours. Bioavailability is low (less than 10% of the dose taken) as a result of a possible rapid passage through the liver. The elimination half-life is about 2 hours. It is excreted mainly by the kidneys along with metabolites.

Indications

Acute and chronic bronchopulmonary diseases accompanied by the formation of viscous, difficult to separate sputum (tracheitis, bronchitis, tracheobronchitis, bronchial asthma, bronchiectatic disease) and mucus (inflammatory diseases of the middle ear, nose and otitis media) .

Preparation of the patient for bronchoscopy or bronchography.

Contraindications

Hypersensitivity to carbocysteine ​​or other components of the drug.

Peptic ulcer of the stomach and duodenum in the acute stage.

Chronic glomerulonephritis (in the acute phase), cystitis.

Pregnancy.

Children under 15 years old.

With caution

a history of gastric and duodenal ulcer, a history of lactation.

Use during pregnancy and lactation

Contraindicated in pregnancy. Caution should be exercised during breastfeeding.

Composition

Active ingredient: carbocysteine ​​5 g

Excipients:

sucrose - 40 g

methyl parahydroxybenzoate - 0.15 g

dye caramel, powder (E150) - 0.0344 g

aromatic brown oil alcohol - 55.3%, rum - 42.7%,

rum flavor - 2.0%) - 2 ml

sodium hydroxide - qs to pH 6.1–6.3

purified water - up to 100 ml

Dosage and Administration

Inside.

One measuring cup of syrup (15 ml) contains 750 mg of carbocysteine. Take 3 times a day in one measuring cup (15 ml), preferably separately from a meal. The duration of treatment should not exceed 8 days.

Side effects of

From the gastrointestinal tract: nausea, vomiting, diarrhea, epigastric pain, gastrointestinal bleeding are sometimes noted.

Allergic reactions: itching, urticaria, exanthema, angioedema.

Other: dizziness, weakness, malaise.

Overdose

Symptoms: gastralgia, nausea, diarrhea.

Treatment: symptomatic.

Storage conditions

Store at a temperature not exceeding 25 ° C.

Expiration

3 years.



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dosage form

oral solution



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