Levomycetin eye drops 0.25%, 10 ml (chloramphenicol)

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florida495737
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Pharmacological action

Levomycetin is an antimicrobial agent effective against a wide range of gram-positive and gram-negative microorganisms. It has a pronounced bacteriostatic effect, in high concentrations in relation to some strains it shows a bactericidal effect.

The mechanism of action is based on the ability to bind to the 50S subunit of bacterial ribosomes and inhibit protein synthesis in bacterial cells. Strains of Escherichia coli, Shigella spp. Are sensitive to the action of chloramphenicol. (including Shigella dysenteria), Salmonella spp., Streptococcus spp. (including Streptococcus pneumoniae), Neisseria spp., Proteus spp., Ricketsia spp., Treponema spp. and Chlamydia trachomatis. Moreover, the drug is effective in diseases caused by certain strains of Pseudomonas aeruginosa. The effect of the drug does not apply to fungi, protozoa and strains of Mycobacterium tuberculosis.

The resistance of microorganisms to chloramphenicol develops slowly. After oral administration, the drug is rapidly absorbed in the gastrointestinal tract. Oral bioavailability reaches 80%. The peak in plasma concentrations is observed 1-3 hours after administration. After oral administration, therapeutically significant concentrations remain in the blood plasma for 4-6 hours, after parenteral administration for 8-12 hours.

The degree of binding of chlorpheniramine to plasma proteins is about 50%. Chloramphenicol crosses the blood-brain and blood-brain barrier, excreted in breast milk. Metabolized in the liver, excreted mainly by the kidneys, some of the drug is excreted by the intestines. The half-life reaches 1.5-3.5 hours.

In patients with impaired renal function, the elimination half-life increases to 3-4 hours, in patients with impaired liver function - up to 11 hours. Buy Levomycetin eye drops 0.25%, 10 ml (chloramphenicol) in florida free shipping. Fast international shipping USA, AU, EU, UK and others.
Pharmacological action

Levomycetin is an antimicrobial agent effective against a wide range of gram-positive and gram-negative microorganisms. It has a pronounced bacteriostatic effect, in high concentrations in relation to some strains it shows a bactericidal effect.

The mechanism of action is based on the ability to bind to the 50S subunit of bacterial ribosomes and inhibit protein synthesis in bacterial cells. Strains of Escherichia coli, Shigella spp. Are sensitive to the action of chloramphenicol. (including Shigella dysenteria), Salmonella spp., Streptococcus spp. (including Streptococcus pneumoniae), Neisseria spp., Proteus spp., Ricketsia spp., Treponema spp. and Chlamydia trachomatis. Moreover, the drug is effective in diseases caused by certain strains of Pseudomonas aeruginosa. The effect of the drug does not apply to fungi, protozoa and strains of Mycobacterium tuberculosis.

The resistance of microorganisms to chloramphenicol develops slowly. After oral administration, the drug is rapidly absorbed in the gastrointestinal tract. Oral bioavailability reaches 80%. The peak in plasma concentrations is observed 1-3 hours after administration. After oral administration, therapeutically significant concentrations remain in the blood plasma for 4-6 hours, after parenteral administration for 8-12 hours.

The degree of binding of chlorpheniramine to plasma proteins is about 50%. Chloramphenicol crosses the blood-brain and blood-brain barrier, excreted in breast milk. Metabolized in the liver, excreted mainly by the kidneys, some of the drug is excreted by the intestines. The half-life reaches 1.5-3.5 hours.

In patients with impaired renal function, the elimination half-life increases to 3-4 hours, in patients with impaired liver function - up to 11 hours.

Indications

Bacterial infections of the eye, including conjunctivitis, keratitis, keratoconjunctivitis, blepharitis, episiscleritis, scleritis

Contraindications

Hypersensitivity, hematopoietic diseases, acute intermittent porphyria, severe renal and hepatic impairment, glucose-6-phosphate dehydrogenase deficiency, psoriasis, eczema, fungal skin diseases, neonatal period (up to 4 weeks) and early childhood.

Ingredients

Active ingredient: chloramphenicol

Dosage and Administration

Locally, 0. 25% aqueous solution - 1-2 drops per conjunctival sac every 1-4 hours (conjunctival sac usually holds only 1 cap) 1% ophthalmic liniment (about 1 cm) - put in for an eyelid every 3 hours.

Side effects

From the digestive tract: dyspepsia, nausea, vomiting, diarrhea, irritation of the mucous membrane of the mouth and throat, dysbiosis.

From the cardiovascular system and blood (hematopoiesis, hemostasis): leukopenia, thrombocytopenia, reticulocytopenia, hypogemoglobinemia, agranulocytosis, aplastic anemia.

From the nervous system and sensory organs: psychomotor disorders, depression, impaired consciousness, delirium, optic neuritis, visual and auditory hallucinations, taste disturbance, decreased hearing and visual acuity, headache.

Allergic reactions: skin rash, urticaria, angioedema.

Other: dermatitis, secondary fungal infection, cardiovascular collapse (in children under 1 year).

active substance

Chloramphenicol

Terms of delivery from

pharmacies Prescription

Dosage

drops eye

Prescribing

Adults as prescribed by a doctor, Children as prescribed by a doctor

Indications

from inflammatory diseases of the eye, blepharitis, conjunctivitis, For barley in the eye

Diapharm, Russia



Levomycetin eye drops 0.25%, 10 ml (chloramphenicol) florida in pharmacy online. Cheap price, instruction, side effects, dosage. Levomycetin eye drops 0.25%, 10 ml - Sale. PayPal accept. Free shipping florida. Fast international shipping.

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