Komfoderm ointment 0, 1% 30 g 30 g (methylprednisolone atseponat)

Release form

Ointment for external use 0.1% white to white with a grayish or yellowish tint, a characteristic odor is allowed.

Packaging

30 g - aluminum tubes (1) - packs of cardboard.

Pharmacological action of

corticosteroids for external use. Suppresses the function of white blood cells and tissue macrophages. It limits the migration of leukocytes to the area of ​​inflammation. It violates the ability of macrophages to phagocytosis, as well as to the formation of interleukin-1. Helps stabilize lysosomal membranes, thereby reducing the concentration of proteolytic enzymes in the area of ​​inflammation. Reduces capillary permeability due to histamine release. Suppresses fibroblast activity and collagen formation.

Inhibits the activity of phospholipase A2, which inhibits the synthesis of prostaglandins and leukotrienes. It inhibits the release of COX (mainly COX-2), which also helps to reduce the production of prostaglandins.

Reduces the number of circulating lymphocytes (T- and B-cells), monocytes, eosinophils and basophils due to their movement from the vascular bed to the lymphoid tissue, inhibits the formation of antibodies.

Methylprednisolone aceponate inhibits the release of ACTH and -lipotropin by the pituitary gland, but does not reduce the level of circulating -endorphin. It inhibits the secretion of TSH and FSH.

With direct application to the vessels, it causes a vasoconstrictor effect.

With external and local application, the therapeutic activity of methylprednisolone is due to anti-inflammatory, anti-allergic and antiexudative (due to vasoconstrictor effect) action.

Indications

Inflammatory skin diseases sensitive to topical glucocorticosteroid therapy: atopic dermatitis, neurodermatitis, childhood eczema

true eczema

microbial eczema

occupational eczema

simple contact dermatitis

allergic (contact) dermatitis

dyshidrotic eczema.

Composition of

100 g of ointment contains:

Active ingredient:

methylprednisolone aceponate in terms of 100% substance - 0.1 g

Excipients:

petroleum jelly - 44.7 g

common paraffin liquid - 34.1 g oil - 3.2 g

white beeswax - 17.9 g

Dosage and administration

Apply externally 1 time / day with a thin layer on the affected area, gently rubbing.

Can be used with an occlusive dressing.

Typically, the course of treatment for adults is no more than 12 weeks, and for children no more than 4 weeks.

Several courses of therapy are possible throughout the year.

Overdose of

When studying the acute toxicity of megylprednisolone aceponate, there was no risk of acute intoxication with excessive single skin use (applying the drug over a large area under conditions favorable for absorption) or unintentional ingestion.

With excessively long and / or intensive use of glucocorticosteroids for continuous use, skin atrophy may develop (thinning of the skin, telangiectasia, striae)

Active ingredient

Methylprednisolone aceponate

Dispensing conditions from pharmacies

Over-the-counter

lekarstvennaja form

ointment

Akrikhin CPC JSC, Russia



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