Ketonal capsules 50 mg, 25 pcs. (Ketoprofen)

Latin name

Ketonal

Release form

Capsules.

Packing

25 capsules of 50 mg.

Pharmacological action

Ketonal - NSAIDs, a derivative of propionic acid.

It has analgesic, anti-inflammatory and antipyretic effects.

The mechanism of action is associated with inhibition of prostaglandin synthesis at the level of cyclooxygenase.

In addition, ketoprofen inhibits lipoxygenase, has anti-bradykinin activity, stabilizes lysosomal membranes, and significantly inhibits neutrophil activity in patients with rheumatoid arthritis.

The pronounced analgesic effect of ketoprofen is due to two mechanisms: peripheral (indirectly, through suppression of prostaglandin synthesis) and central (due to inhibition of prostaglandin synthesis in the central and peripheral nervous system).

Indications

Symptomatic therapy of painful inflammatory processes of various origins (including postoperative and posttraumatic pain, sciatica, myalgia, lumbago, bruises and muscle strains, rheumatoid arthritis, ankylosing spondylitis, osteoarthritis, acute attack of gout, tendosynovitis, bursitis).

Contraindications

gastrointestinal disease in the exacerbation phase

severe hepatic impairment

severe renal impairment

blood disorders (leukopenia, thrombocytopenia, coagulation system disorders) I

children under 15 years old

hemorrhoids and proctitis (for suppositories)

hypersensitivity to ketoprofen, acetylsalicylic acid or other NSAIDs (history of bronchospasm, urticaria and rhinitis caused by acetyl administration).

Use during pregnancy and lactation

The use of Ketonal in the third trimester of pregnancy is contraindicated.

The use of Ketonal in the first and second trimesters of pregnancy is possible only if the potential benefit to the mother outweighs the risk to the fetus.

If you need to use Ketonal during lactation, you should decide on the termination of breastfeeding.

Composition

1 capsule contains:

Active ingredient: ketoprofen - 50 mg.

Excipients: lactose, magnesium stearate, colloidal silicon dioxide.

capsule shell composition: gelatin, titanium dioxide, dye blue patented Patent blue V.

Dosage and administration of

Adults: 1-2 caps. 2-3 times / day, or 1 tab. 2 times / day, or 1 tab. prolonged action 1 time / day.

Capsules and tablets should be taken during or immediately after a meal, without chewing, drinking plenty of water or milk (liquid volume - at least 100 ml).

Oral forms can be combined with the use of rectal suppositories or dosage forms of Ketonal for external use (cream, gel).

The maximum daily dose (including when using various dosage forms) is 200 mg.

Drug Interaction

Because ketotifen is highly bound to plasma proteins, the doses used concomitantly with the Ketonal of anticoagulants, diphenylhydantoin or sulfur-containing drugs should be reduced.

Overdose

Symptoms: nausea, vomiting, abdominal pain, vomiting with blood, melena, impaired consciousness, respiratory depression, seizures, impaired renal function, renal failure.

Treatment: gastric lavage, activated charcoal administration, symptomatic therapy.

The use of histamine H2 receptor blockers, proton pump inhibitors, and prostaglandin inhibitors has been demonstrated. There is no specific antidote.

Storage conditions

Keep out of the reach of children at a temperature not exceeding 25 ° C.

Expiration

5 years.

Deystvuyuschee substances

Ketoprofen

dosage form

dosage form

capsules

Lek dd, Switzerland



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