Indovazin gel, 45 g

Special Price $23.76 Regular Price $24.00
In stock
SKU
FL10205253
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Category

Diseases of the veins

Scope of the drug

Musculoskeletal system

Release form

Gel

Manufacturer country

Bulgaria

Package quantity, pcs

one

Description

Release form, composition and packaging

Gel for external use from yellow to yellow-brown color, with a slight opalescence.

1 g

indomethacin 30 mg

troxerutin 20 mg

carbomer - 23 mg, macrogol 400 - 524.5 mg, sodium benzoate - 2.5 mg, propylene glycol - 100 mg, ethanol 96% - 300 mg.

45 g - aluminum tubes (1) - cardboard packs.

pharmachologic effect

Indovasingel is a combination drug that includes indomethacin and troxerutin.

Indomethacin has a pronounced anti-inflammatory, analgesic and decongestant effect.

This leads to pain relief, less swelling and a shorter recovery time for damaged tissues.

The main mechanism of action is associated with the suppression of prostaglandin synthesis through the reversible blockade of COX-1 and COX-2.

Troxerutin (trihydroxyethylrutinoside) is a bioflavonoid.

It belongs to angioprotective agents.

Reduces capillary permeability and exhibits venotonic effect.

Blocks the venodilating effect of histamine, bradykinin and acetylcholine.

It has an anti-inflammatory effect on the perivenous tissue, reduces capillary fragility and has some antiplatelet effect.

Reduces swelling, improves trophism in pathological changes associated with venous insufficiency.

When applied to the skin, Indovasingel suppresses the inflammatory edematous reaction, relieves pain and temperature in the foci of inflammation located on the surface and in depth, reaching the blood vessels located there.

Shows venotonic and capillary-protective effect.

Pharmacokinetics

The ointment base used provides solubility and release of indomethacin and troxerutin.

The gel dosage form, which includes indomethacin and troxerutin, is well absorbed from the skin surface and provides a therapeutic effect of the drug.

When applied to the skin, concentrations close to therapeutic are created in the subcutaneous tissue and periarticular tissues.

The penetration of the active components of the drug into the systemic circulation is clinically insignificant.

Indications for use

- in the complex therapy of chronic venous insufficiency of the lower extremities (varicose veins) - to relieve swelling, feeling of heaviness and pain in the legs

- superficial thrombophlebitis, phlebitis, postphlebitis conditions

- rheumatic lesions of soft tissues: tendovaginitis, bursitis, fibrositis, periarthritis

- with edema after surgery, contusions, dislocations, sprains.

Contraindications for use

- violation of the integrity of the skin

- III trimester of pregnancy

- lactation period (breastfeeding)

- children under 14 years of age (there is no clinical experience of use)

- hypersensitivity to drug components and NSAIDs.

With care: simultaneous administration of the drug with other NSAIDs, bronchial asthma, allergic rhinitis, polyps of the nasal mucosa.

Dosage regimen

The drug is intended for external use.

4-5 cm of gel is applied 3-4 times / day with a thin layer on the affected area with light rubbing movements.

The total daily amount should not exceed 20 cm. The duration of treatment should not exceed 10 days.

Overdose

There is no evidence of cases of overdose with topical application.

If large amounts are accidentally swallowed, a burning sensation in the mouth, salivation, nausea, and vomiting may occur.

Treatment: washing of the mouth and stomach, if necessary, symptomatic treatment.

Side effect

The drug is usually well tolerated.

Local reactions: symptoms of hypersensitivity from the skin may appear - contact dermatitis, itching, redness, rash, a feeling of warmth and burning at the site of application.

Drug interactions

Ointment can

Name ENG

INDOVASIN

Clinical and pharmacological group

Drug with anti-inflammatory and angioprotective action for external use

ATX code

Indomethacin in combination with other drugs

Dosage

3g / 100g + 2g / 100g x 45g

Structure

100 g: indomethacin 3 g, troxerutin 2 g. Excipients: carbomer - 2.3 g, macrogol 400 - 52.45 g, sodium benzoate - 0.25 g, propylene glycol - 10 g, ethanol 96% - 30 g.

Indications

in the complex therapy of chronic venous insufficiency of the lower extremities (varicose veins) - to relieve edema, feeling of heaviness and pain in the legs

superficial thrombophlebitis, phlebitis, postphlebitis conditions

rheumatic lesions of soft tissues: tendovaginitis, bursitis, fibrositis, periarthritis

with edema after surgical interventions, contusions, dislocations, sprains.

Storage conditions and periods

At a temperature not higher than 25 degrees.

Contraindications

violation of the integrity of the skin

III trimester of pregnancy

lactation period (breastfeeding)

children under 14 years of age (there is no clinical experience of use)

hypersensitivity to drug components and NSAIDs.

With care: simultaneous administration of the drug with other NSAIDs, bronchial asthma, allergic rhinitis, polyps of the nasal mucosa.

INN / Active ingredient

troxerutin + indomethacin

Specifications

Category

Diseases of the veins

Scope of the drug

Musculoskeletal system

Release form

Gel

Manufacturer country

Bulgaria

Package quantity, pcs

one

Way of introduction

On the skin

Vacation conditions

Without recipe

Brand name

Actavis

The amount of the dosage form in the primary package

45 g

Primary packaging type

Tuba

Type of consumer packaging

Pack of cardboard

Anatomical and therapeutic characteristics

M01AB51 Indomethacin, in combination with other drugs

Dosage form

Gel for external use

Dosage (volume) of the substance in the preparation

100 g: indomethacin 3 g, troxerutin 2 g

The target audience

Adult

Expiration date in days

730

Package weight, g

65

Mode of application

:

Outwardly, 1-2 cm of the gel is applied to the affected areas 2-3 times a day with light rubbing movements.

The course of treatment is no more than 10 days without consulting a doctor.

Information on technical characteristics, delivery set, country of manufacture

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