Imunofan rectal suppositories 90 mcg 5 pcs. (Arginyl-alpha-aspartyl-lysyl-valyl-tyrosyl-arginine)

Release form

Suppositories for rectal administration. homogeneous suppositories from white to white with a yellowish tint, torpedo-shaped. A slight specific odor is allowed.



packaging In blister packs of 5 or 10 pcs. in a pack of cardboard 1 or 2 packaging.

Pharmacological action

The preparation of thyroid hormones. Synthetic levorotatory isomer of thyroxine. After partial conversion to triiodothyronine (in the liver and kidneys) and transition to body cells, it affects the development and growth of tissues, and metabolism. In small doses, it has an anabolic effect on protein and fat metabolism. In medium doses, it stimulates growth and development, increases the need for tissue in oxygen, stimulates the metabolism of proteins, fats and carbohydrates, inhibits the breakdown of cell membrane phospholipids and the synthesis of arachidonic acid, followed by a decrease in blood cholesterol and the production of inflammatory mediators.

In case of toxic and infectious liver damage, the drug prevents cytolysis, reduces the activity of transaminases (AST, ALT) and serum bilirubin content.

During the middle phase (starts in 2-3 days, duration - up to 7-10 days), the reactions of phagocytosis and death of intracellular bacteria and viruses intensify.

During the slow phase (begins to develop on days 7-10, duration up to 4 months), the immunoregulatory effect of Imunofan is manifested - the restoration of impaired indicators of cellular and humoral immunity. During this period, the normalization of the immuno-regulatory index is observed, correction of the immune system, restoration of the balance of the oxidative-antioxidant reaction of the body, and inhibition of multiple drug resistance mediated by the transmembrane transport pump proteins of the cell.

The action of the drug begins to develop within 2-3 hours (fast phase) and lasts up to 4 months (medium and slow phases).

During the fast phase (duration - up to 2-3 days), the detoxifying effect is manifested primarily - the antioxidant defense of the body is enhanced by stimulating the production of ceruloplasmin, lactoferrin, catalase activity, the drug normalizes lipid peroxidation, inhibits the breakdown of cell membrane phospholipids and the synthesis of arachidonic acid followed by lowering blood cholesterol and the production of inflammatory mediators.

In case of toxic and infectious liver damage, the drug prevents cytolysis, reduces the activity of transaminases (AST, ALT) and serum bilirubin content.

During the middle phase (starts in 2-3 days, duration - up to 7-10 days), the reactions of phagocytosis and death of intracellular bacteria and viruses intensify.

During the slow phase (begins to develop on days 7-10, duration up to 4 months), the immunoregulatory effect of Imunofan is manifested - the restoration of impaired indicators of cellular and humoral immunity. During this period, the normalization of the immuno-regulatory index is observed, an increase in the production of specific antiviral and antibacterial antibodies is observed equivalent to the action of some therapeutic vaccines. Unlike the latter, the drug does not significantly affect the production of IgE class reagin antibodies and does not enhance the immediate-type hypersensitivity reaction. Imunofan stimulates the formation of IgA in case of congenital insufficiency.

Imunofan effectively suppresses the multidrug resistance of tumor cells and increases their sensitivity to the action of cytostatic drugs.

Indications

Used in adults and children over two years of age for the prevention and treatment of immunodeficiency and toxic conditions, chronic inflammatory diseases of various etiologies.

In adults, as an adjuvant for vaccination against bacterial and viral infections.

Contraindications

Hypersensitivity

Pregnancy complicated by rhesus conflict

Children under 2 years of age.

Use during pregnancy and lactation

Due to insufficient knowledge, it should be used with caution during pregnancy and lactation.

Ingredients

1 supp.

immunofan 100 mcg

excipients: purified water glycine solid fat twin 80

Dosage and administration

Rectally. Single dose and daily - 100 mcg (0.1 mg) 1 suppository.

In the treatment of cancer patients in a radical combination treatment regimen (chemo-radiation therapy and surgery)

Once, daily, a course of treatment of 8 - 10 suppositories before chemo-radiation therapy and surgery, followed by the continuation of the course throughout the treatment period.

In patients with a widespread tumor process (stage III - IV) of various localization in the form of complex or symptomatic therapy

Once, daily, a course of treatment of 8-10 suppositories, with a break of 15-20 days and the repetition of courses throughout the entire period of subsequent treatment.

In children with malignant diseases of the hematopoietic and lymphoid tissue

1 time per day, daily, the course of treatment is 10-20 suppositories. The appointment of the drug should be carried out throughout the course of chemo-radiation therapy and after the end of the course to prevent the development of toxicosis.

In the complex therapy of children with larynx and oropharynx papillomatosis

once a day, daily, a course of treatment of 10 suppositories.

For opportunistic infections (cytomegalovirus and herpetic infections, toxoplasmosis, chlamydia, pneumocystosis, cryptosporidiosis)

1 time per day, daily, course of treatment 15 to 20 suppositories.

In the complex treatment of HIV infection

once a day, daily, the course of treatment is 15 to 20 suppositories. If necessary, repeat courses should be given after 2-4 weeks.

In case of chronic viral hepatitis and chronic brucellosis

once a day, daily, the course of treatment is 15 to 20 suppositories, to prevent relapse, repeated courses should be taken after 2 to 3 months.

With diphtheria

once a day, daily, the course of treatment is 8 to 10 suppositories. With diphtheria bacteriocarrier - 1 time after 3 days - 3-5 suppositories.

In the treatment of burns of the III-IV degree with the effects of toxemia, septicotoxemia, in surgical patients with septic endocarditis, long-term healing of limb wounds, purulent-septic complications

once a day, daily, the course of treatment is 7-10 suppositories, if necessary, the course of the drug should be continue up to 20 suppositories.

With broncho-obstructive syndrome, cholecystopancreatitis, rheumatoid arthritis

1 time after 3 days, the course of treatment is 8 to 10 suppositories, if necessary, the course should be continued up to 20 suppositories with the same interval.

In the treatment of psoriasis

once a day, daily, the course of treatment is 15 to 20 suppositories.

In adults in the

vaccination schedule Once a day on vaccination.

Side effects

Possibly: individual intolerance, allergic reactions.

Drug Interaction

Increases the effectiveness of other types of drug therapy: the use of immunophane helps overcome glucocorticosteroid resistance.

The drug can be given in combination with anti-inflammatory steroid and non-steroidal anti-inflammatory drugs.

Storage Conditions

The product is stored in a dark place at 2 ° C to 10 ° C, out of the reach of children. It is not recommended to use the product after the expiry date stated on the package.

Shelf life

2 years.

Deystvuyushtee substance

Arginyl-alyfa -aspartyl-lysyl-valyl-tyrosyl-arginine

Terms and conditions

prescription

dosage form

rectal suppositories

Possible product names

IMUNOFAN 100MKG N5 SUPP REKT

Imunofan 100mkg Supp. rect. X5 M

IMUNOFAN 100MKG. No. 5 SUPP.RECT.

Imunofan rectal suppositories 100 mcg, 5 pcs.

IMUNOFAN SUPP RECT 100 MKG No. 5

Bionoks, Russia



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