Helmimax-10 tablets 120 mg for puppies and adult dogs of large breeds Api-San 2 pcs. (ewaf moxidectin, praziquantel)
Special Price
$26.73
Regular Price
$27.00
In stock
SKU
florida949659
Pharmacological action
Helmimax refers to combination anthelmintic drugs.
The combination of praziquantel and moxidectin, which are part of the preparation, provides a wide spectrum of its anthelmintic effect on gastrointestinal nematodes (Tohosara sanis, Toxocara cati (Tohosara mistax), Toxascaris leonina, Uncinaria stenocephala, Trichuris vulpis canisumcy, Anichocis ancycy , Alveococus multilocularis, Mesocestoides lineatus, Dipylidium caninum, Diphyllobotrium latum, Multiceps multiceps), parasitic in dogs and cats.
Praziquantel is a compound of the pyrazinisoquinoline group, which is active against gastrointestinal cestodes at all phases of development. Increasing the permeability of the parasite’s cell membranes for calcium ions (Ca2 +), it causes membrane depolarization, muscle contraction and the destruction of the tegument, which leads to the death of helminths and helps them to be excreted from the animal’s body. The compound is rapidly absorbed in the gastrointestinal tract, reaching a maximum plasma concentration after 1 - 3 hours, reversibly binds to blood serum proteins (70 - 80%), is partially metabolized in the liver, re-secreted into the intestines, excreted mainly in the urine (up to 80%) within 24 hours.
moxidectin is derived from chemically modified nemadectin, a fermentation product of Streptomyces cyanogriseus noncyanogenus, is a semi-synthetic compound from the milbemycin group.
Moxidectin has an antiparasitic effect against nematodes and arachnoentomoses. Its main target is glutamate-sensitive chlorine channels, as well as gamma-aminobutyric acid receptors. A change in the current of chlorine ions disrupts the conduction of nerve impulses, which leads to paralysis and death of the parasite.
Moxidectin also has an additional potentiating effect on gamma-aminobutyric acid (hereinafter GABA), accelerating its excretion from presynaptic terminals and facilitating its absorption by postsynaptic receptors of the peripheral nervous system. The attachment of GABA to the receptors of glutamate-sensitive chlorine channels stimulates the influx of chlorine ions, which leads to the development of paralysis. Mammals lack glutamate-sensitive chlorine channels (the inefficiency of moxidectin against cestode and trematodes is most likely also due to their lack of glutamate-sensitive chlorine channels).
Moxidectin is well absorbed, enters the systemic circulation, and is excreted from the body mainly unchanged with feces.
Helmimax, by its degree of exposure to the body, is classified as moderately hazardous (hazard class 3 according to GOST 12.1.007-76), does not have an embryotoxic, teratogenic and sensitizing effect in recommended doses, and is well tolerated by dogs and cats of different breeds and ages. Buy Helmimax-10 tablets 120 mg for puppies and adult dogs of large breeds Api-San 2 pcs. (ewaf moxidectin, praziquantel) in florida free shipping. Fast international shipping USA, AU, EU, UK and others.
Helmimax refers to combination anthelmintic drugs.
The combination of praziquantel and moxidectin, which are part of the preparation, provides a wide spectrum of its anthelmintic effect on gastrointestinal nematodes (Tohosara sanis, Toxocara cati (Tohosara mistax), Toxascaris leonina, Uncinaria stenocephala, Trichuris vulpis canisumcy, Anichocis ancycy , Alveococus multilocularis, Mesocestoides lineatus, Dipylidium caninum, Diphyllobotrium latum, Multiceps multiceps), parasitic in dogs and cats.
Praziquantel is a compound of the pyrazinisoquinoline group, which is active against gastrointestinal cestodes at all phases of development. Increasing the permeability of the parasite’s cell membranes for calcium ions (Ca2 +), it causes membrane depolarization, muscle contraction and the destruction of the tegument, which leads to the death of helminths and helps them to be excreted from the animal’s body. The compound is rapidly absorbed in the gastrointestinal tract, reaching a maximum plasma concentration after 1 - 3 hours, reversibly binds to blood serum proteins (70 - 80%), is partially metabolized in the liver, re-secreted into the intestines, excreted mainly in the urine (up to 80%) within 24 hours.
moxidectin is derived from chemically modified nemadectin, a fermentation product of Streptomyces cyanogriseus noncyanogenus, is a semi-synthetic compound from the milbemycin group.
Moxidectin has an antiparasitic effect against nematodes and arachnoentomoses. Its main target is glutamate-sensitive chlorine channels, as well as gamma-aminobutyric acid receptors. A change in the current of chlorine ions disrupts the conduction of nerve impulses, which leads to paralysis and death of the parasite.
Moxidectin also has an additional potentiating effect on gamma-aminobutyric acid (hereinafter GABA), accelerating its excretion from presynaptic terminals and facilitating its absorption by postsynaptic receptors of the peripheral nervous system. The attachment of GABA to the receptors of glutamate-sensitive chlorine channels stimulates the influx of chlorine ions, which leads to the development of paralysis. Mammals lack glutamate-sensitive chlorine channels (the inefficiency of moxidectin against cestode and trematodes is most likely also due to their lack of glutamate-sensitive chlorine channels).
Moxidectin is well absorbed, enters the systemic circulation, and is excreted from the body mainly unchanged with feces.
Helmimax, by its degree of exposure to the body, is classified as moderately hazardous (hazard class 3 according to GOST 12.1.007-76), does not have an embryotoxic, teratogenic and sensitizing effect in recommended doses, and is well tolerated by dogs and cats of different breeds and ages. Buy Helmimax-10 tablets 120 mg for puppies and adult dogs of large breeds Api-San 2 pcs. (ewaf moxidectin, praziquantel) in florida free shipping. Fast international shipping USA, AU, EU, UK and others.
Pharmacological action
Helmimax refers to combination anthelmintic drugs.
The combination of praziquantel and moxidectin, which are part of the preparation, provides a wide spectrum of its anthelmintic effect on gastrointestinal nematodes (Tohosara sanis, Toxocara cati (Tohosara mistax), Toxascaris leonina, Uncinaria stenocephala, Trichuris vulpis canisumcy, Anichocis ancycy , Alveococus multilocularis, Mesocestoides lineatus, Dipylidium caninum, Diphyllobotrium latum, Multiceps multiceps), parasitic in dogs and cats.
Praziquantel is a compound of the pyrazinisoquinoline group, which is active against gastrointestinal cestodes at all phases of development. Increasing the permeability of the parasite’s cell membranes for calcium ions (Ca2 +), it causes membrane depolarization, muscle contraction and the destruction of the tegument, which leads to the death of helminths and helps them to be excreted from the animal’s body. The compound is rapidly absorbed in the gastrointestinal tract, reaching a maximum plasma concentration after 1 - 3 hours, reversibly binds to blood serum proteins (70 - 80%), is partially metabolized in the liver, re-secreted into the intestines, excreted mainly in the urine (up to 80%) within 24 hours.
moxidectin is derived from chemically modified nemadectin, a fermentation product of Streptomyces cyanogriseus noncyanogenus, is a semi-synthetic compound from the milbemycin group.
Moxidectin has an antiparasitic effect against nematodes and arachnoentomoses. Its main target is glutamate-sensitive chlorine channels, as well as gamma-aminobutyric acid receptors. A change in the current of chlorine ions disrupts the conduction of nerve impulses, which leads to paralysis and death of the parasite.
Moxidectin also has an additional potentiating effect on gamma-aminobutyric acid (hereinafter GABA), accelerating its excretion from presynaptic terminals and facilitating its absorption by postsynaptic receptors of the peripheral nervous system. The attachment of GABA to the receptors of glutamate-sensitive chlorine channels stimulates the influx of chlorine ions, which leads to the development of paralysis. Mammals lack glutamate-sensitive chlorine channels (the inefficiency of moxidectin against cestode and trematodes is most likely also due to their lack of glutamate-sensitive chlorine channels).
Moxidectin is well absorbed, enters the systemic circulation, and is excreted from the body mainly unchanged with feces.
Helmimax, by its degree of exposure to the body, is classified as moderately hazardous (hazard class 3 according to GOST 12.1.007-76), does not have an embryotoxic, teratogenic and sensitizing effect in recommended doses, and is well tolerated by dogs and cats of different breeds and ages.
Indications
Helmimax is given to dogs and cats for prophylactic and therapeutic purposes in case of nematodoses (toxocariasis, toxoscaridosis, uncinariosis, trichocephalosis, hookworm infection), cestodoses (teniidosis, dipyloidiosis, echinococcus, echinococcus, echinococcus, echinococcus, echinococcus, echinococcus, echinococcus, echinococcus, echinococcus, echinococcus, echinococcus, echinococci, echinococci, mesocestoidosis) and mixed nematode-cestodose invasions, as well as for the prevention of dirofilariasis.
Contraindications
Contraindication to use is individual intolerance to the components of the drug (including a history), severe renal and hepatic impairment. Do not use the drug in animals weighing less than 0.5 kg.
The use of the drug is not recommended for dogs of collie, sheltie, and bobtail breeds due to the increased sensitivity of these breeds to macrocyclic lactones.
Depleted and sick animals are not subject to deworming.
Ingredients
Powder rhizomes with white potentilla roots 50mg, kelp powder 10mg, powder of Echinacea purpurea 10mg auxiliary ingredients: milk sugar, calcium stearic acid, hypromellose, titanium dioxide, tween 80 mg. moxidectin - 5 mg / tablet, excipients.
Dosage and administration
The drug is administered individually to animals orally, in the morning with a small amount of feed, or is forcibly administered to the root of the tongue in the following therapeutic doses: moxidectin - 0.25 mg / kg, praziquantel - 5 mg / kg, based :
Weight of the animal (kg)
Dosages
Helmimax-4 for adult cats and kittens, puppies and adult dogs of small breeds
0, 5 - 1
tablets> 1 - 2
tablets> 2 - 4
1
tablet> 4 - 6
1,5 tablets
tablets> 6 - 8
tablets 2 helmimax-10
tablets for puppies and adult dogs of medium breed
5 - 10
1
tablet> 10 - 15
1.5 tablets
> 15 - 20
2 tablets
Helmimax-20 for puppies and adult dogs of large breeds
10 - 20
1 tablet
> 20 - 30
1.5 tablets
> 30 - 40
2 tablets
> 40 - 50
2.5 tablets
> 50 - 60
3 tablets
> 60 - 70
3.5 tablets
> 70 - 80
4 tablets
For preventive purposes, deworming of animals is carried out once a quarter, as well as before each vaccine nation.
For therapeutic purposes, deworming is performed according to indications. With a strong invasion intensity, it is recommended to repeat deworming after 14 days.
In order to prevent dirofilariasis, in regions that are not healthy due to the disease, the drug is used in the spring-summer-autumn period: once before the summer of mosquitoes and mosquitoes, once a month, and last time in the season no earlier than 1 month after the end of the summer of insects .
A preliminary fasting diet and laxatives before deworming are not required.
Side effects of
In case of drug overdose, an animal may experience depression, refusal to feed, excessive salivation, upset gastrointestinal tract, muscle paresis, shaky gait, trembling. In these cases, enterosorbents and symptomatic therapy are used.
Dosage Form
tablets
Helmimax-10 tablets 120 mg for puppies and adult dogs of large breeds Api-San 2 pcs. (ewaf moxidectin, praziquantel) florida in pharmacy online. Cheap price, instruction, side effects, dosage. Helmimax-10 tablets 120 mg for puppies and adult dogs of large breeds Api-San 2 pcs. - Sale. PayPal accept. Free shipping florida. Fast international shipping.
Helmimax refers to combination anthelmintic drugs.
The combination of praziquantel and moxidectin, which are part of the preparation, provides a wide spectrum of its anthelmintic effect on gastrointestinal nematodes (Tohosara sanis, Toxocara cati (Tohosara mistax), Toxascaris leonina, Uncinaria stenocephala, Trichuris vulpis canisumcy, Anichocis ancycy , Alveococus multilocularis, Mesocestoides lineatus, Dipylidium caninum, Diphyllobotrium latum, Multiceps multiceps), parasitic in dogs and cats.
Praziquantel is a compound of the pyrazinisoquinoline group, which is active against gastrointestinal cestodes at all phases of development. Increasing the permeability of the parasite’s cell membranes for calcium ions (Ca2 +), it causes membrane depolarization, muscle contraction and the destruction of the tegument, which leads to the death of helminths and helps them to be excreted from the animal’s body. The compound is rapidly absorbed in the gastrointestinal tract, reaching a maximum plasma concentration after 1 - 3 hours, reversibly binds to blood serum proteins (70 - 80%), is partially metabolized in the liver, re-secreted into the intestines, excreted mainly in the urine (up to 80%) within 24 hours.
moxidectin is derived from chemically modified nemadectin, a fermentation product of Streptomyces cyanogriseus noncyanogenus, is a semi-synthetic compound from the milbemycin group.
Moxidectin has an antiparasitic effect against nematodes and arachnoentomoses. Its main target is glutamate-sensitive chlorine channels, as well as gamma-aminobutyric acid receptors. A change in the current of chlorine ions disrupts the conduction of nerve impulses, which leads to paralysis and death of the parasite.
Moxidectin also has an additional potentiating effect on gamma-aminobutyric acid (hereinafter GABA), accelerating its excretion from presynaptic terminals and facilitating its absorption by postsynaptic receptors of the peripheral nervous system. The attachment of GABA to the receptors of glutamate-sensitive chlorine channels stimulates the influx of chlorine ions, which leads to the development of paralysis. Mammals lack glutamate-sensitive chlorine channels (the inefficiency of moxidectin against cestode and trematodes is most likely also due to their lack of glutamate-sensitive chlorine channels).
Moxidectin is well absorbed, enters the systemic circulation, and is excreted from the body mainly unchanged with feces.
Helmimax, by its degree of exposure to the body, is classified as moderately hazardous (hazard class 3 according to GOST 12.1.007-76), does not have an embryotoxic, teratogenic and sensitizing effect in recommended doses, and is well tolerated by dogs and cats of different breeds and ages.
Indications
Helmimax is given to dogs and cats for prophylactic and therapeutic purposes in case of nematodoses (toxocariasis, toxoscaridosis, uncinariosis, trichocephalosis, hookworm infection), cestodoses (teniidosis, dipyloidiosis, echinococcus, echinococcus, echinococcus, echinococcus, echinococcus, echinococcus, echinococcus, echinococcus, echinococcus, echinococcus, echinococcus, echinococci, echinococci, mesocestoidosis) and mixed nematode-cestodose invasions, as well as for the prevention of dirofilariasis.
Contraindications
Contraindication to use is individual intolerance to the components of the drug (including a history), severe renal and hepatic impairment. Do not use the drug in animals weighing less than 0.5 kg.
The use of the drug is not recommended for dogs of collie, sheltie, and bobtail breeds due to the increased sensitivity of these breeds to macrocyclic lactones.
Depleted and sick animals are not subject to deworming.
Ingredients
Powder rhizomes with white potentilla roots 50mg, kelp powder 10mg, powder of Echinacea purpurea 10mg auxiliary ingredients: milk sugar, calcium stearic acid, hypromellose, titanium dioxide, tween 80 mg. moxidectin - 5 mg / tablet, excipients.
Dosage and administration
The drug is administered individually to animals orally, in the morning with a small amount of feed, or is forcibly administered to the root of the tongue in the following therapeutic doses: moxidectin - 0.25 mg / kg, praziquantel - 5 mg / kg, based :
Weight of the animal (kg)
Dosages
Helmimax-4 for adult cats and kittens, puppies and adult dogs of small breeds
0, 5 - 1
tablets> 1 - 2
tablets> 2 - 4
1
tablet> 4 - 6
1,5 tablets
tablets> 6 - 8
tablets 2 helmimax-10
tablets for puppies and adult dogs of medium breed
5 - 10
1
tablet> 10 - 15
1.5 tablets
> 15 - 20
2 tablets
Helmimax-20 for puppies and adult dogs of large breeds
10 - 20
1 tablet
> 20 - 30
1.5 tablets
> 30 - 40
2 tablets
> 40 - 50
2.5 tablets
> 50 - 60
3 tablets
> 60 - 70
3.5 tablets
> 70 - 80
4 tablets
For preventive purposes, deworming of animals is carried out once a quarter, as well as before each vaccine nation.
For therapeutic purposes, deworming is performed according to indications. With a strong invasion intensity, it is recommended to repeat deworming after 14 days.
In order to prevent dirofilariasis, in regions that are not healthy due to the disease, the drug is used in the spring-summer-autumn period: once before the summer of mosquitoes and mosquitoes, once a month, and last time in the season no earlier than 1 month after the end of the summer of insects .
A preliminary fasting diet and laxatives before deworming are not required.
Side effects of
In case of drug overdose, an animal may experience depression, refusal to feed, excessive salivation, upset gastrointestinal tract, muscle paresis, shaky gait, trembling. In these cases, enterosorbents and symptomatic therapy are used.
Dosage Form
tablets
Helmimax-10 tablets 120 mg for puppies and adult dogs of large breeds Api-San 2 pcs. (ewaf moxidectin, praziquantel) florida in pharmacy online. Cheap price, instruction, side effects, dosage. Helmimax-10 tablets 120 mg for puppies and adult dogs of large breeds Api-San 2 pcs. - Sale. PayPal accept. Free shipping florida. Fast international shipping.
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