Guttalax - tablets # 50, laxative, for constipation

White, round, flat-cylindrical tablets with beveled edges, “5L” is engraved on one side of the tablet on both sides of the dividing marks, practically odorless.

Pharmacodynamics

The active ingredient, sodium picosulfate, is a laxative of the triarylmethane group.

As a local laxative, sodium picosulfate, after bacterial breakdown in the large intestine, has a stimulating effect on the mucous membrane of the large intestine, increasing peristalsis, promotes the accumulation of water and electrolytes in the large intestine.

This leads to the stimulation of the act of defecation, a decrease in the evacuation time and softening of the stool.

Sodium picosulfate, as a laxative at the level of the colon, stimulates the natural process of evacuation of contents from the lower gastrointestinal tract.

Therefore, sodium picosulfate has no effect on the digestion or absorption of high-calorie foods or essential nutrients in the small intestine.

In a randomized, double-blind, parallel group study involving 367 patients with chronic constipation, the effect of Guttalax В® was investigated.

The study results showed a significant increase in intestinal motility during the week compared with placebo for all four weeks of therapy (p < 0.0001).

Serum potassium levels were unchanged at the end of the study (4.4 mM) and corresponded to the physiological norm (3.6-5.3 mM).

Pharmacokinetics

Absorption and distribution

After oral administration of sodium, picosulfate enters the colon without significant absorption.

Thus, enterohepatic circulation of the drug is excluded.

Biotransformation

In the distal colon, sodium picosulfate is degraded by bacteria to form an active metabolite of bis- (p-hydroxyphenyl) -pyridyl-2-methane (BHPM), which has a laxative effect.

Withdrawal

After cleavage, a small amount of BGPM is absorbed and then almost completely binds in the intestinal wall and liver with the formation of an inactive glucuronide.

After oral administration of sodium picosulfate at a dose of 10 mg (about 10.4% of the total dose), the drug is excreted in the urine in the form of BGPM-glucuronide after 48 hours.

With the use of sodium picosulfate in higher doses, its excretion by the kidneys decreases.

Specifications

Package weight, g

45