Granisetron-TL tablets coated. captivity. about. 1 mg 10 pcs. (Granisetron)

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Pharmacological action

Antiemetic. Selective antagonist of serotonin 5HT3 receptors. It stops vomiting that occurs when the parasympathetic nervous system is excited due to the release of serotonin by enterochromaffin cells.

Pharmacokinetics of

After iv administration in doses of 20 Ојg / kg or 40 Ојg / kg, the average Cmax in blood plasma is 13.7 Ојg / L and 42.8 Ојg / L, respectively.

Plasma Protein Binding - 65%.

Metabolized rapidly by demethylation and oxidation.

T1 / 2 is 3.1-5.9 hours. In cancer patients, T1 / 2 rises to 10-12 hours. It is excreted in the urine and feces, mainly in the form of conjugates, 8-15% is found in the urine unchanged. Buy Granisetron-TL tablets coated. captivity. about. 1 mg 10 pcs. (Granisetron) in florida free shipping. Fast international shipping USA, AU, EU, UK and others.
Pharmacological action

Antiemetic. Selective antagonist of serotonin 5HT3 receptors. It stops vomiting that occurs when the parasympathetic nervous system is excited due to the release of serotonin by enterochromaffin cells.

Pharmacokinetics of

After iv administration in doses of 20 Ојg / kg or 40 Ојg / kg, the average Cmax in blood plasma is 13.7 Ојg / L and 42.8 Ојg / L, respectively.

Plasma Protein Binding - 65%.

Metabolized rapidly by demethylation and oxidation.

T1 / 2 is 3.1-5.9 hours. In cancer patients, T1 / 2 rises to 10-12 hours. It is excreted in the urine and feces, mainly in the form of conjugates, 8-15% is found in the urine unchanged.

Indications

Prevention and treatment of nausea and vomiting during chemotherapy with cytostatics.

Prevention and treatment of postoperative nausea and vomiting.

Contraindications

Hypersensitivity to granisetron.

Special instructions

Use with caution in case of symptoms of bowel obstruction.

Granisetron is not used for the treatment and prevention of postoperative nausea and vomiting in children.

Composition

1 tab. contains: Active substances: granisetron hydrochloride - 1.12 mg, which corresponds to the content of granisetron - 1 mg.

Excipients: microcrystalline cellulose - 36 mg, lactose monohydrate - 57.63 mg, pregelatinized starch - 5 mg, magnesium stearate - 0.25 mg.

Composition of the film coat: Aquarius Prime BAP218010 white - 3 mg (hypromellose - 65%, titanium dioxide - 25%, macrogol - 10%).

Dosage and administration of

For adults, a single dose for oral administration is 1 mg, for intravenous infusion a single dose is 3 mg, for intravenous injection (slowly, for at least 30 sec) a single dose is 1 mg.

The maximum dose is 9 mg / day.

In children in the drip once - 40 mcg / kg (but not more than 3 mg). Children over 12 years of age for oral administration of a single dose - 1 mg.

The frequency and duration of use are set individually

Side effects

Possible: transient increase in the activity of hepatic transaminases in the blood, constipation, headache, skin rash.

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Granisetron-TL tablets coated. captivity. about. 1 mg 10 pcs. (Granisetron) florida in pharmacy online. Cheap price, instruction, side effects, dosage. Granisetron-TL tablets coated. captivity. about. 1 mg 10 pcs. - Sale. PayPal accept. Free shipping florida. Fast international shipping.

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