Generolone spray for external use 5% 60mls

pharmachologic effect

A baldness remedy.

Has a stimulating effect on hair growth in men and women with androgenic alopecia (male pattern baldness).

The appearance of signs of hair growth is noted after 4 months or more of using the drug 2 times / day.

The onset and severity of the effect may vary from patient to patient.

After the abolition of minoxidil, the growth of new hair stops, and after 3-4 months, the original appearance can be restored.

The exact mechanism of action of minoxidil as a hair growth stimulant in patients with androgenic alopecia is unknown.

With systemic use, minoxidil has a vasodilating effect.

In controlled clinical studies after topical application of minoxidil in patients with both normal and elevated blood pressure, there were no systemic side effects associated with systemic absorption of minoxidil.

Pharmacokinetics

When applied externally, minoxidil is poorly absorbed through normal, intact skin: on average, 1.4% (0.3-4.5%) of the total applied dose enters the systemic circulation.

When applied externally, the concentration of minoxidil in serum is determined by the rate of its absorption through the skin.

After discontinuation of use, approximately 95% of minoxidil that has undergone systemic absorption is excreted within 4 days.

Indications

Androgenic alopecia in men and women (in order to restore the hairline or stabilize the process of hair loss).

ICD-10 codes

Dosage regimen

Apply to the scalp at a dose of 2 times / day (morning and evening).

Side effect

Dermatological reactions: often - redness, itching, peeling of the scalp

in some cases, hypertrichosis (unwanted body hair growth, including facial hair growth in women).

It is possible to increase hair loss during the transition from the resting phase to the hair growth phase (this temporary phenomenon occurs 2-6 weeks after the start of therapy and gradually, within 2 weeks, stops).

From the side of the cardiovascular system: in some cases - arterial hypotension.

Contraindications for use

Children and adolescents up to 18 years old

redness, inflammation, infection, soreness of the scalp (including with sunburn)

hypersensitivity to minoxidil.

Application during pregnancy and lactation

Do not use during pregnancy and lactation (breastfeeding).

Application in children

Contraindicated in children and adolescents under 18 years of age.

special instructions

If systemic side effects appear (chest pain, palpitations, dizziness, decreased blood pressure, sudden weight gain, swelling of the arms and / or legs), as well as redness and irritation at the site of rubbing, minoxidil should be canceled and appropriate therapy should be prescribed, if necessary.

In some patients, changes in hair color and structure were observed after using minoxidil.

Drug interactions

With the simultaneous application of minoxidil to the skin and preparations for external use containing tretinoin, anthralin / dithranol (which cause a change in the protective function of the skin), an increase in the absorption of minoxidil is possible.

Name ENG

GENEROLON

Clinical and pharmacological group

Drug for the treatment of alopecia in men and women

ATX code

Minoxidil

Dosage

5% x 60ml

Structure

Spray for external use in the form of a colorless or slightly colored with a yellowish tinge, a transparent aqueous-alcoholic solution with the smell of alcohol.

1 ml.

minoxidil 50 mg.

Excipients: ethanol 96% - 243 mg, propylene glycol - 520 mg, water - up to 1 ml.

INN / Active ingredient

Minoxidil

Storage conditions and periods

At a temperature not higher than 25 degrees.

Expiration date: 4 years

Specifications

Category

Baldness

Scope of the drug

Dermatology

Release form

Spray

Manufacturer country

Spain

Package quantity, pcs

one

Way of introduction

On the skin

Vacation conditions

Without recipe

Brand name

Belupo

Components

spray nozzle, metering pump

The amount of the dosage form in the primary package

60 ml

Primary packaging type

Bottle

Type of consumer packaging

Pack of cardboard

Pharmaco-therapeutic group

Alopecia Remedy

Anatomical and therapeutic characteristics

D11AX01 Minoxidil [Topical]

Dosage form

Spray for external use

Expiration date in days

1460

Dosage (volume) of the substance in the preparation

minoxidil 50 mg

Package weight, g

one hundred

Mode of application

:

Apply to the scalp at a dose of 2 times / day (morning and evening).