Furosemide tablets 40 mg, 50 pcs. (Furosemide)

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Latin name srdlpp

Packing

50 pcs

Pharmacological action

Furosemide natriuretic, diuretic.

It inhibits the reabsorption of sodium ions in the ascending knee of the Henle loop, proximal and distal tubules. Increases the excretion of bicarbonates, phosphates, calcium, magnesium.

Indications

Edema with circulatory failure, liver and kidney diseases, difficulty in venous outflow, after burns and phlebothrombosis

ascites (against a malignant neoplasm, liver and cardiac origin)

peripheral pulmonary edema, srdlp threatening, post-traumatic cerebral edema, arterial hypertension

toxicosis of pregnancy, labor eclampsia, premenstrual tension syndrome, prerenal uremia, hyperkalemia, forced diuresis (poisoning with chemical compounds, including barbiturates).

Contraindications

Hypersensitivity, anuria, uremia, hepatic coma, mechanical obstruction of the urinary tract, dyselectrolytemia.

Use during pregnancy and lactation

During pregnancy only if there is good reason and for a short time (in the III-IV trimester). Contraindicated during lactation.

Composition

1 tablet contains:

Active ingredient: furosemide 40 mg

Excipients: lactose starch potato MCC povidone gelatin magnesium stearate silicon dioxide colloidal talc.

Dosage and administration

Inside adults with edema - 40 mg once a day (up to 80-120 mg / day), after increasing diuresis, the dose is reduced to a maintenance dose - 40 mg every other day.

For children - at the rate of 1-2 mg / kg / day.

Side effects of

From the cardiovascular system: decreased blood pressure, orthostatic hypotension, collapse, tachycardia, arrhythmias, decreased bcc.

From the side of the central nervous system and peripheral nervous system: dizziness, headache, myasthenia gravis, muscle cramps (tetany), paresthesia, apathy, adynamia, weakness, lethargy, drowsiness, confusion.

On the part of the sensory organs: impaired vision and hearing.

From the digestive system: decreased appetite, dry mouth, thirst, nausea, vomiting, constipation or diarrhea, cholestatic jaundice, pancreatitis (exacerbation).

From the genitourinary system: oliguria, acute urinary retention (in patients with prostatic hypertrophy), interstitial nephritis, hematuria, decreased potency.

From the hematopoietic system: leukopenia, thrombocytopenia, agranulocytosis, aplastic anemia.

On the part of water-electrolyte metabolism: hypovolemia, dehydration (risk of thrombosis and thromboembolism), hypokalemia, hyponatremia, hypochloremia, hypocalcemia, hypomagnesemia, metabolic alkalosis.

From the side of metabolism: hypovolemia, hypokalemia, hyponatremia, hypochloremia, hypokalemic metabolic alkalosis (as a result of these disorders - arterial hypotension, dizziness, dry mouth, thirst, arrhythmia, muscle weakness, cramps), hyperuricemia (with possible hyperglycemia.

Allergic reactions: purpura, urticaria, exfoliative dermatitis, erythema multiforme exudative, vasculitis, necrotizing angiitis, pruritus, chills, fever, photosensitivity, anaphylactic shock.

Other: with intravenous administration (optional) - thrombophlebitis, renal calcification in premature infants.

Drug Interaction

Concomitant use of Furosemide with cardiac glycosides increases the risk of glycoside intoxication, and when combined with ACS, the risk of hypokalemia.

When co-administered, Furosemide potentiates the effect of muscle relaxants.

When co-administered with Furosemide with aminoglycosides or cephalosporins and cisplatin, it is possible to increase their plasma concentration, which can lead to the development of nephro- and ototoxic effects.

When used with NSAIDs may reduce the diuretic effect of Furosemide.

When used with Furosemide and antihypertensive drugs, the hypotensive effect is potentiated.

When used together with Furosemide, the action of hypoglycemic agents and pressor amines may be impaired.

Overdose

Symptoms: decreased blood pressure, collapse, shock, hypovolemia, dehydration, hemoconcentration, arrhythmias, acute renal failure with anuria, thrombosis, thromboembolism, drowsiness, confusion, confusion, apathy.

Treatment: correction of water-salt balance and acid-base state (CBS), circulation of circulating blood volume, symptomatic treatment. There is no specific antidote.

Storage conditions

The drug should be stored in a dry, dark place at a temperature not exceeding 25 ° C.

The Expiration of

is 3 years.

Deystvuyuschee substances

Furosemide



pharmacy terms for prescription

dosage form

dosage form

tablets

Ozon, Russia



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