Furagin tablets 50 mg, 10 pcs. (Furazidine)
Special Price
$21.78
Regular Price
$22.00
In stock
SKU
florida473362
Release form
Tablets. Buy Furagin tablets 50 mg, 10 pcs. (Furazidine) in florida free shipping. Fast international shipping USA, AU, EU, UK and others.
Tablets. Buy Furagin tablets 50 mg, 10 pcs. (Furazidine) in florida free shipping. Fast international shipping USA, AU, EU, UK and others.
Release form
Tablets.
Packing
10 pcs.
Pharmacological action
Pharmacodynamics
Antimicrobial agent, derivative of nitrofuran. Effective against gram-positive cocci (Staphylococcus spp., Streptococcus spp.), Gram-negative rods (Escherichia coli, Salmonella spp., Shigella spp., Klebsiella spp.). Resistant Pseudomonas aeruginosa, Enterococcus spp., Acinetobacter spp., Most strains of Proteus spp., Serratia spp. Furazidine is reduced by bacterial flavoproteins to active compounds that inactivate or damage the proteins of bacterial ribosomes and other macromolecules.
As a result, aerobic respiration and the synthesis of protein, cell wall, DNA and RNA are disrupted. The multiple mechanism of action explains the weak acquired resistance of microorganisms to nitrofurans. Depending on the concentration, it has a bactericidal or bacteriostatic effect. Against most bacteria, the bacteriostatic concentration is from 10 to 20 μg / ml.
The bactericidal concentration is about 2 times higher. As a result of the action of nitrofurans, microorganisms emit less toxins, and therefore, an improvement in the general condition of the patient is possible even before the pronounced suppression of microflora growth.
Pharmacokinetics
Absorption - in the small intestine, by passive diffusion. Absorption of nitrofurans from the distal segment of the small intestine exceeds absorption from the proximal and medial segments by 2 and 4 times, respectively (should be taken into account in the treatment of urinary tract diseases in combination with diseases of the gastrointestinal tract, including with chronic enteritis).
Poorly absorbed in the colon. It is distributed evenly. It is found in high concentrations in lymph in bile, its concentration is several times higher than in serum, in cerebrospinal fluid - several times lower, than in serum, saliva contains up to 30% of the concentration in serum in blood and tissues, the concentration is small, which is associated with its rapid excretion, while its concentration in urine is much higher than in blood.
The maximum concentration (Cmax) in the blood serum lasts from 3 to 7-8 hours, in the urine it is detected after 3-4 hours. It does not change the pH of urine, unlike nitrofurantoin. It is metabolized in the liver (less than 10%), with a decrease in renal excretory function, the metabolic rate increases.
Excreted by the kidneys by glomerular filtration and tubular secretion (85%), partially undergoes reverse reabsorption in the tubules. At low concentrations in the urine, the filtration and secretion process predominates, at high concentrations, secretion decreases and reabsorption increases. Being a weak acid does not dissociate at acidic urine pH values, undergoes intensive reabsorption, which can enhance systemic side effects.
Indications
Infectious and inflammatory diseases: urinary tract (cystitis, urethritis, pyelonephritis) infections of the female genital organs infection prevention during urological operations, cystoscopy, catheterization.
Contraindications
Hypersensitivity to furazidine, other components of the drug
hypersensitivity to nitrofuran derivatives
impaired renal function
impaired liver function
lactase deficiency, sucrose / isomaltose, lactose intolerance, lactose intolerance, lactose intolerance, lactose intolerance, glucose-galactose malabsorption
pregnancy
lactation
children under 18 years of age.
Furazidine is not recommended for urosepsis and kidney parenchyma infections.
Caution
For anemia, lung disease (especially in patients over 65), diseases of the nervous system, diabetes mellitus, porphyria, deficiency of glucose-6-phosphate dehydrogenase, B vitamins and folic acid.
Special instructions
Drink plenty of water to prevent side effects. To prevent the development of neuritis, it is necessary to prescribe vitamins of group B. Stains urine in brown.
With prolonged use, monitoring of the picture of peripheral blood, renal and liver function, and lung function is necessary.
False positive results are possible when determining glucose in the urine using enzymatic methods.
Given the possible side effects of the nervous system during the use of the drug, care must be taken when engaging in potentially dangerous activities, requiring a hung concentration of attention and speed of psychomotor reactions.
Influence on ability to steer vehicles, mechanisms.
Given the side effects of the drug, you should refrain from performing these activities.
Composition
Active ingredient:
furazidine - 50.0 mg.
Excipients:
lactose monohydrate - 18.8 mg
sucrose - 10.2 mg
potato starch - 20.0 mg
calcium stearate - 1.0 mg.
Dosage and administration of
Furagin is taken orally, after meals - 50-100 mg 3 times a day for 7-10 days. If necessary, you can conduct a second course of treatment after 10-15 days, for the prevention of infections during urological operations, cystoscopy, catheterization is taken once 50 mg 30 minutes before surgery or manipulation.
The maximum daily dose is 600 mg.
Side effects of
From the gastrointestinal tract: nausea, vomiting, decreased appetite, anorexia, diarrhea, pancreatitis.
From the nervous system: dizziness, headache, drowsiness, weakness, peripheral neuropathy, the development of polyneuritis.
From the side of the organ of vision: visual impairment.
From the liver and biliary tract: impaired liver function, cholestatic jaundice, hepatitis.
From the side of musculoskeletal and connective tissue: myalgia, arthralgia.
From the blood and lymphatic system: agranulocytosis, thrombocytopenia, aplastic anemia, eosinophilia.
From the respiratory system, chest and mediastinal organs: shortness of breath, chest pain, cough with and without sputum, interstitial pneumonitis, pulmonary fibrosis.
From the vessels: intracranial hypertension.
From the skin and subcutaneous tissues: skin rash (including papular), enanthema, angioedema, pruritus, urticaria, exfoliative dermatitis, erythema multiforme.
Other: fever, reversible alopecia.
Drug Interactions
Concomitant use with ristomycin, chloramphenicol, sulfonamides increases the risk of hematotoxic effects. Avoid the simultaneous use of other derivatives of nitrofuran, as well as drugs "acidifying" urine (including ascorbic acid, calcium chloride). Ethanol can increase the severity of side effects.
Probenecid and sulfinpyrazone decrease urinary excretion of furazidine. This can lead to cumulation of furazidine and increase its toxicity.
With the simultaneous use of magnesium-containing antacids, the absorption of furazidine decreases.
Overdose
Symptoms: neurotoxic reactions, polyneuritis, impaired liver function, acute toxic hepatitis.
Treatment: withdrawal of Furagin, intake of a large amount of liquid, symptomatic therapy, antihistamines, B vitamins. There is no specific antidote.
Active ingredient
Furazidine
dosage form
tablets
Furagin tablets 50 mg, 10 pcs. (Furazidine) florida in pharmacy online. Cheap price, instruction, side effects, dosage. Furagin tablets 50 mg, 10 pcs. - Sale. PayPal accept. Free shipping florida. Fast international shipping.
Tablets.
Packing
10 pcs.
Pharmacological action
Pharmacodynamics
Antimicrobial agent, derivative of nitrofuran. Effective against gram-positive cocci (Staphylococcus spp., Streptococcus spp.), Gram-negative rods (Escherichia coli, Salmonella spp., Shigella spp., Klebsiella spp.). Resistant Pseudomonas aeruginosa, Enterococcus spp., Acinetobacter spp., Most strains of Proteus spp., Serratia spp. Furazidine is reduced by bacterial flavoproteins to active compounds that inactivate or damage the proteins of bacterial ribosomes and other macromolecules.
As a result, aerobic respiration and the synthesis of protein, cell wall, DNA and RNA are disrupted. The multiple mechanism of action explains the weak acquired resistance of microorganisms to nitrofurans. Depending on the concentration, it has a bactericidal or bacteriostatic effect. Against most bacteria, the bacteriostatic concentration is from 10 to 20 μg / ml.
The bactericidal concentration is about 2 times higher. As a result of the action of nitrofurans, microorganisms emit less toxins, and therefore, an improvement in the general condition of the patient is possible even before the pronounced suppression of microflora growth.
Pharmacokinetics
Absorption - in the small intestine, by passive diffusion. Absorption of nitrofurans from the distal segment of the small intestine exceeds absorption from the proximal and medial segments by 2 and 4 times, respectively (should be taken into account in the treatment of urinary tract diseases in combination with diseases of the gastrointestinal tract, including with chronic enteritis).
Poorly absorbed in the colon. It is distributed evenly. It is found in high concentrations in lymph in bile, its concentration is several times higher than in serum, in cerebrospinal fluid - several times lower, than in serum, saliva contains up to 30% of the concentration in serum in blood and tissues, the concentration is small, which is associated with its rapid excretion, while its concentration in urine is much higher than in blood.
The maximum concentration (Cmax) in the blood serum lasts from 3 to 7-8 hours, in the urine it is detected after 3-4 hours. It does not change the pH of urine, unlike nitrofurantoin. It is metabolized in the liver (less than 10%), with a decrease in renal excretory function, the metabolic rate increases.
Excreted by the kidneys by glomerular filtration and tubular secretion (85%), partially undergoes reverse reabsorption in the tubules. At low concentrations in the urine, the filtration and secretion process predominates, at high concentrations, secretion decreases and reabsorption increases. Being a weak acid does not dissociate at acidic urine pH values, undergoes intensive reabsorption, which can enhance systemic side effects.
Indications
Infectious and inflammatory diseases: urinary tract (cystitis, urethritis, pyelonephritis) infections of the female genital organs infection prevention during urological operations, cystoscopy, catheterization.
Contraindications
Hypersensitivity to furazidine, other components of the drug
hypersensitivity to nitrofuran derivatives
impaired renal function
impaired liver function
lactase deficiency, sucrose / isomaltose, lactose intolerance, lactose intolerance, lactose intolerance, lactose intolerance, glucose-galactose malabsorption
pregnancy
lactation
children under 18 years of age.
Furazidine is not recommended for urosepsis and kidney parenchyma infections.
Caution
For anemia, lung disease (especially in patients over 65), diseases of the nervous system, diabetes mellitus, porphyria, deficiency of glucose-6-phosphate dehydrogenase, B vitamins and folic acid.
Special instructions
Drink plenty of water to prevent side effects. To prevent the development of neuritis, it is necessary to prescribe vitamins of group B. Stains urine in brown.
With prolonged use, monitoring of the picture of peripheral blood, renal and liver function, and lung function is necessary.
False positive results are possible when determining glucose in the urine using enzymatic methods.
Given the possible side effects of the nervous system during the use of the drug, care must be taken when engaging in potentially dangerous activities, requiring a hung concentration of attention and speed of psychomotor reactions.
Influence on ability to steer vehicles, mechanisms.
Given the side effects of the drug, you should refrain from performing these activities.
Composition
Active ingredient:
furazidine - 50.0 mg.
Excipients:
lactose monohydrate - 18.8 mg
sucrose - 10.2 mg
potato starch - 20.0 mg
calcium stearate - 1.0 mg.
Dosage and administration of
Furagin is taken orally, after meals - 50-100 mg 3 times a day for 7-10 days. If necessary, you can conduct a second course of treatment after 10-15 days, for the prevention of infections during urological operations, cystoscopy, catheterization is taken once 50 mg 30 minutes before surgery or manipulation.
The maximum daily dose is 600 mg.
Side effects of
From the gastrointestinal tract: nausea, vomiting, decreased appetite, anorexia, diarrhea, pancreatitis.
From the nervous system: dizziness, headache, drowsiness, weakness, peripheral neuropathy, the development of polyneuritis.
From the side of the organ of vision: visual impairment.
From the liver and biliary tract: impaired liver function, cholestatic jaundice, hepatitis.
From the side of musculoskeletal and connective tissue: myalgia, arthralgia.
From the blood and lymphatic system: agranulocytosis, thrombocytopenia, aplastic anemia, eosinophilia.
From the respiratory system, chest and mediastinal organs: shortness of breath, chest pain, cough with and without sputum, interstitial pneumonitis, pulmonary fibrosis.
From the vessels: intracranial hypertension.
From the skin and subcutaneous tissues: skin rash (including papular), enanthema, angioedema, pruritus, urticaria, exfoliative dermatitis, erythema multiforme.
Other: fever, reversible alopecia.
Drug Interactions
Concomitant use with ristomycin, chloramphenicol, sulfonamides increases the risk of hematotoxic effects. Avoid the simultaneous use of other derivatives of nitrofuran, as well as drugs "acidifying" urine (including ascorbic acid, calcium chloride). Ethanol can increase the severity of side effects.
Probenecid and sulfinpyrazone decrease urinary excretion of furazidine. This can lead to cumulation of furazidine and increase its toxicity.
With the simultaneous use of magnesium-containing antacids, the absorption of furazidine decreases.
Overdose
Symptoms: neurotoxic reactions, polyneuritis, impaired liver function, acute toxic hepatitis.
Treatment: withdrawal of Furagin, intake of a large amount of liquid, symptomatic therapy, antihistamines, B vitamins. There is no specific antidote.
Active ingredient
Furazidine
dosage form
tablets
Furagin tablets 50 mg, 10 pcs. (Furazidine) florida in pharmacy online. Cheap price, instruction, side effects, dosage. Furagin tablets 50 mg, 10 pcs. - Sale. PayPal accept. Free shipping florida. Fast international shipping.
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