fluimucil effervescent tablets 600 mg 20 pcs. (Acetylcysteine)

Latin name

Fluimucil

Packaging

20 pcs.

Pharmacological action

Fluimucil - mucolytic.

Thins phlegm. The presence of sulfhydryl groups in the structure of acetylcysteine ​​helps to break the disulfide bonds of acid mucopolysaccharides of sputum, which leads to the depolymerization of mucoproteins and to a decrease in the viscosity of mucus. The drug remains active in the presence of purulent sputum.

Acetylcysteine ​​has an antioxidant effect due to the presence of a nucleophilic thiol SH-group, which easily gives off hydrogen, neutralizing oxidative radicals.

Pharmacodynamics

With the prophylactic use of acetylcysteine, there is a decrease in the frequency and severity of exacerbations in patients with chronic bronchitis and cystic fibrosis. The protective mechanism of acetylcysteine ​​is based on the ability of its reactive sulfhydryl groups to bind chemical radicals.

Acetylcysteine ​​easily penetrates into the cell, deacetylated to L-cysteine, from which intracellular glutathione is synthesized. Glutathione - a highly reactive tripeptide, a powerful antioxidant, cytoprotector, trapping endogenous and exogenous free radicals and toxins.

Acetylcysteine ​​prevents depletion and enhances the synthesis of intracellular glutathione, which is involved in the oxidation-reduction processes of cells, i.e. contributing to the detoxification of harmful substances. This explains the effect of acetylcysteine ​​as an antidote for paracetamol poisoning.

Pharmacokinetics

Fluimucil is well absorbed when taken orally. It immediately deacetylates to cysteine ​​in the liver. In the blood there is a dynamic balance of free and plasma proteins bound acetylcysteine ​​and its metabolites (cysteine, cystine, diacetylcystine).

Due to the high first-pass effect through the liver, the bioavailability of acetylcysteine ​​is about 10%. Acetylcysteine ​​penetrates into the intercellular space, mainly distributed in the liver, kidneys, lungs, bronchial secretions.

After oral administration of 600 mg of acetylcysteine ​​by healthy volunteers, Cmax in plasma is reached after approximately 1 h and is 15 mmol / L, with iv administration - 300 mmol / L. T1 / 2 from plasma - 2 hours. Acetylcysteine ​​and its metabolites are excreted mainly by the kidneys.

Indications

Respiratory diseases accompanied by the formation of increased viscosity sputum (acute and chronic bronchitis, pneumonia, bronchiectasis, cystic fibrosis, bronchial asthma).

Contraindications

Hypersensitivity to acetylcysteine, peptic ulcer of the stomach and duodenum in the acute stage, age up to 18 years (effervescent tablets).

Use during pregnancy and lactation

Use during pregnancy and breastfeeding is only possible if the intended benefit to the mother outweighs the potential risk to the fetus or baby.

Composition

1 tablet contains:

Active ingredient:

acetylcysteine600 mg

Excipients:

citric acid

sodium bicarbonate

aspartame

lemon flavor.

Dosage and administration

1 tablet is dissolved in 1/3 cup of water and taken 1 time per day.

Duration of treatment should be evaluated individually.

In acute diseases, the duration of treatment is from 5 to 10 days and up to several months in the treatment of chronic diseases (on the recommendation of a doctor).

Side effects

When taken orally, nausea, heartburn, vomiting, diarrhea, skin rash, itching, urticaria, nosebleeds, tinnitus are rare.

Cases of the development of bronchospasm, collapse, stomatitis, decreased platelet aggregation are described.

Drug Interaction

The combined use of acetylcysteine ​​with antitussive agents may increase phlegm stagnation due to cough reflex suppression.

When used with antibiotics such as tetracyclines (excluding doxycycline), ampicillin, amphotericin B, their interaction with the thiol group of acetylcysteine ​​may occur, which leads to a decrease in the activity of both drugs. Therefore, the interval between the administration of these drugs should be at least 2 hours

Concurrent administration of acetylcysteine ​​and nitroglycerin can lead to increased vasodilator and disaggregant action of the latter.

Acetylcysteine ​​eliminates the toxic effects of paracetamol.

Storage Conditions

At room temperature (not higher than 25 ° C).

shelf life

3 years

Terms and conditions otpuska IZ drugstore

Without prescription

dosage form

tablets soluble

Possible product names

Fluimucil TAB. SPIKE. 600MG No. 20

Fluimucil tablet spike. 600mg N20 Switzerland

Fluimucil effervescent tablets 600 mg 20 pcs.

Fluimucil effervescent tablets 600 mg, 20 pcs.

fluimucil spike. TAB. 600MG No. 20

Zambon S.P.A., Italy



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