Dexalgin gran. d / prigot. r-ra d / int. reception 25mg # 10

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SKU
FL10206015
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Category

Pain relievers

,

Migraine

Scope of the drug

General

Release form

Granules

Manufacturer country

Spain

Package quantity, pcs

ten

Description

pharmachologic effect

NSAID, a derivative of phenylacetic acid.

It has a pronounced anti-inflammatory, analgesic and moderate antipyretic effect.

The mechanism of action is associated with inhibition of the activity of COX, the main enzyme of the metabolism of arachidonic acid, which is a precursor of prostaglandins, which play a major role in the pathogenesis of inflammation, pain and fever.

The analgesic effect is due to two mechanisms: peripheral (indirectly, through suppression of prostaglandin synthesis) and central (due to inhibition of prostaglandin synthesis in the central and peripheral nervous system).

Inhibits the synthesis of proteoglycan in cartilage.

In rheumatic diseases, it reduces joint pain at rest and during movement, as well as morning stiffness and swelling of the joints, and helps to increase the range of motion.

Reduces post-traumatic and postoperative pain, as well as inflammatory edema.

Suppresses platelet aggregation.

With prolonged use, it has a desensitizing effect.

When applied topically in ophthalmology, it reduces edema and pain in inflammatory processes of non-infectious etiology.

Indications

Inflammatory and degenerative diseases of the musculoskeletal system: rheumatoid arthritis, psoriatic, juvenile chronic arthritis, ankylosing spondylitis

rheumatic lesions of soft tissues

gouty arthritis)

traumatic inflammation of the tendons, ligaments, muscles and joints (as a result of sprains, stress and bruises).

Contraindications

- complete or incomplete combination of bronchial asthma, recurrent polyposis of the nose and paranasal sinuses, and intolerance to acetylsalicylic acid or other NSAIDs (in history)

- violation of the integrity of the skin

- pregnancy (III trimester)

- lactation period

- children's age (up to 12 years old)

- hypersensitivity to diclofenac or other components of the drug, acetylsalicylic acid or other NSAIDs.

Carefully

Hepatic porphyria (exacerbation), erosive and ulcerative lesions of the gastrointestinal tract (in the exacerbation phase), severe liver and kidney dysfunction, chronic heart failure, bleeding disorders (including hemophilia, prolonged bleeding time, tendency to bleed)

bronchial asthma, advanced age, pregnancy I and II trimester.

Application during pregnancy and lactation

Use during pregnancy (III trimester) and lactation is contraindicated.

With care: pregnancy I and II trimester.

special instructions

The gel is applied only to intact skin areas.

After application, do not apply an occlusive dressing.

When applied to large skin surfaces for a long time, the risk of developing systemic side effects increases.

Avoid getting the drug in the eyes, mucous membranes or open brines.

Use as an external agent only.

Structure

100 g of gel contains:

Active substance

Diclofenac diethylamine 1.16 g.

Which corresponds to diclofenac sodium 1.00 g.

Excipients

Isopropyl alcohol, carbopol 940, polysorbate 80, gasoline alcohol, sodium metabisulfite, sorbitol 70% non-crystallizing, triethanolamine, purified water.

Method of administration and dosage

Outwardly.

For adults and children over 12 years old, the drug is applied in a thin layer over the focus of inflammation 3-4 times / day and rubbed lightly.

The required amount of the drug depends on the size of the painful area.

Single dose of the drug: 2-4 g (which is comparable in volume to the size of a large cherry).

After applying the drug, you must wash your hands.

The duration of treatment depends on the indications and the therapeutic effect.

After 2 weeks of using the drug, you should consult your doctor.

Side effects

From the digestive system: nausea, vomiting, anorexia, pain and discomfort in the epigastric region, flatulence, constipation, diarrhea

in some cases - erosive and ulcerative lesions, bleeding and perforation of the gastrointestinal tract

rarely - liver dysfunction.

With rectal administration, in isolated cases, there was inflammation of the colon with bleeding, exacerbation of ulcerative colitis.

From the side of the central nervous system and peripheral nervous system: dizziness, headache, agitation, insomnia, irritability, fatigue

rarely - paresthesias, visual impairments (blurred, diplopia), tinnitus, sleep disorders, convulsions, irritability, tremors, mental disorders, depression.

From the hematopoietic system: rarely - anemia, leukopenia, thrombocytopenia, agranulocytosis.

From the urinary system: rarely - impaired renal function

edema is possible in predisposed patients.

Dermatological reactions: rarely - hair loss.

Allergic reactions: skin rash, itching

when applied in the form of eye drops - itching, redness, photosensitivity.

Local reactions: at the place of intramuscular injection, burning is possible, in some cases - the formation of infiltration, abscess, necrosis of adipose tissue

with rectal administration, local irritation, the appearance of mucous secretions mixed with blood, painful defecation are possible

when applied externally in rare cases - itching, redness, rash, burning

when applied topically in ophthalmology, a transient burning sensation and / or temporary blurred vision may occur immediately after instillation.

With prolonged external use and / or application to extensive body surfaces, systemic side effects are possible due to the resorptive action of diclofenac.

Drug interactions

The drug can enhance the effect of drugs that cause photosensitization.

No clinically significant interaction with other drugs has been described.

Storage conditions

Keep out of the reach of children, at a temperature of 15 В° to 25 В° C.

Shelf life

3 years

Active substance

Diclofenac

Name ENG

DICLOFENAC

Clinical and pharmacological group

NSAIDs for external use

ATX code

Diclofenac

Dosage

1% x 100g

Structure

100 g of gel contains: Active ingredient. Diclofenac diethylamine 1.16 g. Which corresponds to diclofenac sodium 1.00 g. Excipients. Isopropyl alcohol, Carbopol 940, Polysorbate 80, gasoline alcohol, sodium metabisulfite, sorbitol 70% non-crystallizing, triethanolamine, purified water.

Indications

Inflammatory and degenerative diseases of the musculoskeletal system: rheumatoid arthritis, psoriatic, juvenile chronic arthritis, ankylosing spondylitis

rheumatic lesions of soft tissues

gouty arthritis)

traumatic inflammation of the tendons, ligaments, muscles and joints (as a result of sprains, stress and bruises).

Storage conditions and periods

At a temperature not higher than 25 degrees.

Expiration date: 4 years

after opening - 1 year

Contraindications

complete or incomplete combination of bronchial asthma, recurrent polyposis of the nose and paranasal sinuses, and intolerance to acetylsalicylic acid or other NSAIDs (in history)

violation of the integrity of the skin

pregnancy (III trimester)

lactation period

children's age (up to 12 years old)

hypersensitivity to diclofenac or other components of the drug acetylsalicylic acid or other NSAIDs., With caution, Hepatic porphyria (exacerbation), erosive and ulcerative lesions of the gastrointestinal tract (in the exacerbation phase), severe liver and kidney dysfunction, chronic heart failure, blood clotting disorder ( including hemophilia, lengthening of bleeding time, tendency to bleeding)

bronchial asthma, advanced age, pregnancy I and II trimester. <

INN / Active ingredient

Diclofenac

Specifications

Category

Anesthesia and muscle relaxants

,

Bruises, sprains

Scope of the drug

Musculoskeletal system

Release form

Gel

Manufacturer country

Germany

Package quantity, pcs

one

Scope of application

Orthopedics

Minimum age from

12 years

Way of introduction

Locally

,

Outwardly

Vacation conditions

Without recipe

Brand name

Teva

The amount of the dosage form in the primary package

100 g

Primary packaging type

Tuba

Type of consumer packaging

Pack of cardboard

Pharmaco-therapeutic group

NSAIDs

Anatomical and therapeutic characteristics

M02AA15 Diclofenac

Dosage form

Gel for external use

Packaging

Cardboard box

The target audience

Children

Expiration date in days

1095

Dosage (volume) of the substance in the preparation

diclofenac sodium 10 mg

Drug action

Anti-inflammatory

,

Analgesic

,

Antipyretic

Package weight, g

135

Mode of application

: https://translate.google.com/translate?hl=&sl=ru&tl=en&u=https://zz.buy-pharm.com/xzzalgp.html;Description

Release form

Granules for preparation of oral solution

pharmachologic effect

NSAIDs.

It has anti-inflammatory, analgesic and antipyretic effects.

The mechanism of action is based on inhibition of prostaglandin synthesis due to suppression of COX.

The analgesic effect occurs 30 minutes after ingestion, the duration of the action is 4-6 hours.

Pharmacokinetics

After taking the drug inside, Cmax of dexketoprofen in humans is reached on average after 30 minutes (15-60 minutes).

Plasma protein binding - 99%.

Average Vd - less than 0.25 l / kg.

T1 / 2 is 1.65 hours. It is metabolized.

It is excreted mainly by the kidneys in the form of metabolites.

Indications

Pain syndrome of mild and moderate intensity in the following diseases and conditions: acute and chronic inflammatory diseases of the musculoskeletal system (rheumatoid arthritis, spondyloarthritis, arthrosis, osteochondrosis)

dysmenorrhea

toothache.

Contraindications

Peptic ulcer and duodenal ulcer, gastrointestinal bleeding, active bleeding of various origins, increased bleeding, anticoagulant therapy, Crohn's disease, ulcerative colitis, bronchial asthma (including a history), severe heart failure, renal failure, liver insufficiency, pregnancy, lactation, hypersensitivity to dexketoprofen or other NSAIDs.

special instructions

Care should be taken when prescribing the drug to elderly patients, patients with allergic reactions, with systemic diseases of the connective tissue and patients with impaired blood formation.

Patients should be informed that in case of side effects, as well as in the absence of a clinical effect within 3-5 days of treatment, it is necessary to inform the attending physician about it.

Special care is required with the simultaneous use of dexketoprofen with phenytoin, sulfonamides and drugs that reduce blood clotting.

Influence on the ability to drive vehicles and use mechanisms

Since dexketoprofen can cause a decrease in the ability to concentrate, it should be used with caution in patients engaged in potentially hazardous activities that require increased attention and speed of psychomotor reactions.

Structure

1 pack.

dexketoprofen trometamol 36.9 mg, which corresponds to the content of dexketoprofen 25 mg.

Excipients: ammonium glycyrrhizinate - 2 mg, dihydrochalcone neohesperidin - 1.5 mg, quinoline yellow dye (E104) - 1.2 mg, lemon flavor - 40 mg, sucrose with colloidal silicon dioxide (500: 1) - 2418 mg.

Method of administration and dosage

Is taken internally.

The average recommended single dose is 12.5 mg - 1-6 times / day every 4-6 hours as needed or 25 mg 1-3 times / day every 8 hours.

The maximum daily dose is 75 mg.

The duration of use is no more than 3-5 days.

For patients with impaired liver or kidney function, the elderly, the initial dose is no more than 50 mg / day.

Side effects

From the digestive system: heartburn, abdominal pain

rarely - erosive and ulcerative lesions of the gastrointestinal tract.

From the nervous system: headaches, dizziness, nervousness, sleep disturbance, paresthesia.

From the side of the cardiovascular system: palpitations, increased blood pressure.

Allergic reactions: skin rash, bronchospasm.

Others: chills, swelling of the extremities, photosensitivity

rarely - a change in the picture of peripheral blood, renal dysfunction.

Drug interactions

With the simultaneous use of dexketoprofen with other NSAIDs, the risk of side effects may increase.

With simultaneous use with lithium preparations, an increase in the concentration of the latter in the blood plasma is possible.

Use dexketoprofen with caution less than 24 hours before the start of use or after the end of therapy with methotrexate, since the concentration of the latter in the blood plasma (and, therefore, toxicity) may increase.

Some cases of bleeding with the simultaneous use of NSAIDs and anticoagulants are described.

Active substance

Dexketoprofen

Storage conditions

Store at a temperature of 15-25 РЎ out of the reach of children.

Name ENG

DEXALGIN

Clinical and pharmacological group

NSAIDs

ATX code

Dexketoprofen

Dosage

25mg x 2.5g

Structure

1 pack of dexketoprofen trometamol 36.9 mg, which corresponds to the content of dexketoprofen 25 mg Excipients: ammonium glycyrrhizinate - 2 mg, neohesperidin dihydrochalcone - 1.5 mg, quinoline yellow dye (E104) - 1.2 mg, lemon flavoring - 40 mg, sucrose with silicon colloidal (500: 1) - 2418 mg.

Indications

Pain syndrome of mild and moderate intensity in the following diseases and conditions: acute and chronic inflammatory diseases of the musculoskeletal system (rheumatoid arthritis, spondyloarthritis, arthrosis, osteochondrosis)

dysmenorrhea

toothache.

Contraindications

Hypersensitivity to dexketoprofen or other NSAIDs

peptic ulcer of the stomach and duodenum

gastrointestinal bleeding

active bleeding of various origins

increased bleeding

anticoagulant therapy

Crohn's disease

nonspecific ulcerative colitis

bronchial asthma (including history)

severe heart failure

severe renal failure

severe liver failure

pregnancy and lactation.

INN / Active ingredient

Dexketoprofen

Storage conditions and periods

At a temperature not higher than 25 degrees.

Expiration date: 3 years

Specifications

Category

Pain relievers

,

Migraine

Scope of the drug

General

Release form

Granules

Manufacturer country

Spain

Package quantity, pcs

ten

Scope of application

Orthopedics

,

Dentistry

Way of introduction

Through the mouth

Vacation conditions

Without recipe

Brand name

Berlin-Chemie

The amount of the dosage form in the primary package

2.5 g

Primary packaging type

Sachet (sachet)

Type of consumer packaging

Pack of cardboard

Pharmaco-therapeutic group

NSAIDs

Anatomical and therapeutic characteristics

M01AE17 Dexketoprofen

Dosage form

Granules for preparation of oral solution

The target audience

Adult

Dosage (volume) of the substance in the preparation

dexketoprofen trometamol 36.9 mg

Expiration date in days

1095

Package weight, g

55

Mode of application

:

Is taken internally.

The average recommended single dose is 12.5 mg - 1-6 times / day every 4-6 hours as needed or 25 mg 1-3 times / day every 8 hours. < br> The maximum daily dose is 75 mg.

Duration of use - no more than 3-5 days. < br> For patients with impaired liver or kidney function, elderly people, the initial dose is no more than 50 mg / day. < br>

Information on technical characteristics, delivery set, country of manufacture "

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