Coldact Plus Plus capsules prolong. 10 pieces. (Paracetamol, phenylephrine, CHLORPHENAMINE)

Release form

Capsules.

Packing

10 pcs - blisters (1) - packs of cardboard.

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Indications

Symptomatic treatment of colds, flu, SARS (fever, pain, rhinorrhea).

Pregnancy and lactation

Coldact Plus Plus capsules are not recommended for use during pregnancy and lactation.

Composition

Active ingredients:

Chlorphenamine maleate 8 mg

Paracetamol 200 mg

Phenylephrine hydrochloride 25 mg

Auxiliary ingredients: talc 68.25 mg, hypromellose 4.5 mg, ethyl cellulose 29 mg, cellulose 28 microcellulose 28 mg , 01 mg, povidone - 6.41 mg, purified water * qs, isopropanol * qs, sodium disulfite 0.16 mg, disodium edetate 0.32 mg, crimson dye (Ponceau 4R) 0.35 mg, sunset yellow dye 0 , 01 mg, dye quinoline yellow 0.08 mg, granules Non Pareil Seeds18 / 22 (sugar grains: sucrose, starch syrup) 124.11 mg.

Capsule shell: gelatin qs up to 100%, purified water 14-15%, methyl parahydroxybenzoate 0.2%, dye azorubine 0.35%, crimson dye (Ponceau 4R) 0.47%.

* is lost during the manufacturing process

Dosage and administration

Adults and children over 12 years old - 1 capsule every 12 hours for 3-5 days.

Duration of use as an antipyretic agent - no more than 3 days as painkiller - no more than 5 days.

Side effects

Increased blood pressure, tachycardia, drowsiness, falling asleep, dizziness, increased irritability, dry mucous membranes, mydriasis, paresis of accommodation, increased intraocular pressure, decreased appetite, nausea, epigastric pain, anemia.

Very rare: urinary retention, allergic reactions (skin rash, itching, urticaria, angioedema).

Rarely: anemia, thrombocytopenia, leukemia, agranulocytosis.

With prolonged use in high doses, hepatotoxic and nephrotic effects are possible.

Drug Interaction

The risk of developing hepatotoxic action of paracetamol is increased by the simultaneous administration of barbiturates, diphenin, carbamazepine, rifampicin, zidovudine and other inducers of microsomal liver enzymes. Enhances the effects of sedatives, ethanol, monoamine oxidase inhibitors. Antidepressants, phenothiazine derivatives, antiparkinsonian and antipsychotic medicines increase the risk of urinary retention, dry mouth, constipation. Glucocorticosteroids increase the risk of developing glaucoma. Paracetamol reduces the effectiveness of uricosuric drugs. Chlorophenamine together with furazolidone can lead to hypertensive crisis, agitation, hyperpyrexia. Tricyclic antidepressants increase the adrenomimetic effect of phenylephrine, and the simultaneous administration of halothane increases the risk of ventricular arrhythmia. Reduces the antihypertensive effect of guanethidine, which in turn enhances the -adrenostimulating activity of phenylephrine. With long-term regular use of paracetamol, the anticoagulation action of warfarin and other coumarin drugs is increased and the risk of bleeding is increased.

Overdose

Symptoms caused by paracetamol are manifested after ingestion of more than 10-15 g: pale skin, decreased appetite, nausea, vomiting, hepatonecrosis, increased activity of hepatic transaminases, increased time of prothrombin.

Treatment: gastric lavage in the first 6 h, administration of SH-group donors and precursors of glutathione-methionine synthesis 8-9 h after overdose and N-acetylcysteine ​​after 12 h. In case of accidental overdose, see a doctor immediately any symptoms of overdose or not.

Storage conditions

Store in a dry place at a temperature not exceeding 25 ° C. Keep out of the reach of children.

Expiration

2 years.

Active ingredient

Paracetamol, Phenylephrine, Chlorophenamine

Dosage form

L Medicinal form

extended-release capsules

Ranbaksi Laboratoriz Limited, India



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