Cereton ampoules 1 g, 4 ml, 5 pcs. (Choline alfostserat)

Release form

Solution for intravenous and intramuscular administration

Packing

5 ampoules of 4 ml.

Pharmacological action

Pharmacodynamics

Cereton is a nootropic drug. Central cholinostimulator, which contains 40.5% metabolically protected choline. Metabolic protection promotes the release of choline in the brain. Provides the synthesis of acetylcholine and phosphatidylcholine in neuronal membranes, improves blood flow and enhances metabolic processes in the central nervous system, activates the reticular formation. It increases the linear velocity of blood flow on the side, traumatic brain damage, helps to normalize spatio-temporal characteristics: spontaneous bioelectrical activity of the brain, regression of focal neurological symptoms and restoration of consciousness, has a positive effect on cognitive and behavioral reactions of patients with cerebrovascular diseases (discirculatory encephalopathy and residual effects) cerebrovascular accident). It has a preventive and corrective effect on pathogenetic factors of the involutional psycho-organic syndrome, changes the phospholipid composition of neuronal membranes: it participates in the synthesis of phosphatidylcholine (membrane phospholipid), improves the plasticity of neuronal membranes. Stimulates dose-dependent secretion of acetylcholine under physiological conditions, improves synaptic transmission, receptor function. It does not affect the reproductive cycle and does not have a teratogenic, mutagenic effect.

Pharmacokinetics of

Parenteral administration (10 mg / kg) Cereton predominantly accumulates in the brain, lungs and liver. Absorption - 88%, easily penetrates the blood-brain barrier (when taken orally, the concentration in the brain is 45% of that in the plasma). 85% of the preparation in the form of carbon dioxide is excreted by the lungs, the remaining amount (15%) is excreted by the kidneys and through the intestines.

Indications

Acute and recovery periods of severe head injury and ischemic stroke, recovery period of hemorrhagic stroke, occurring with focal hemispheric symptoms or symptoms of damage to the brain stem

psycho-organic syndrome against the background of degenerative and involutional changes in the brain

chronic cerebrovascular insufficiency

cognitive disorders (impaired mental function, memory, confusion, disorientation, decreased motivation, initiative and ability to concentrate) including with dementia and encephalopathy

senile pseudomelancholy.

Contraindications

hypersensitivity to the drug

acute stage hemorrhagic stroke

pregnancy breast-feeding

children under 18 years of age (due to lack of data).

Special instructions

Cereton does not affect the rate of psychomotor reactions.

Dosage and administration of

In acute conditions, the solution is administered intravenously (slowly) or deeply intramuscularly at 1000 mg (1 ampoule) per day for 10-15 days.

Side effects of

Nausea may occur (mainly as a result of dopaminergic activation), in which case reduce the dose of the drug.

Allergic reactions.

Solution for injection

From the digestive system: constipation, diarrhea, dry oral mucosa, pharyngitis.

From the nervous system: headache, drowsiness, insomnia, aggressiveness, anxiety, nervousness, cerebral ischemia, cramps, dizziness.

From the skin: rash, urticaria.

Other: pain at the injection site, increased urination.

Overdose

Nausea may be noted. Treatment: symptomatic therapy.

Storage Conditions

In a dark place at 2-25 ° C.

Active substance

choline alfoscerol

Form of Treatment

simply entails dlya inaektsiy and infusing



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