Cefazolin then. d / pr-r solution for in / ven.and in / mouse.input. fl. 1 g (Cephazolin)

Release form

Powder for solution for intravenous and intramuscular administration.

Packaging

In a bottle 1 g of powder. In a cardboard bundle 1 bottle.

Pharmacological action

Cefazolin is a first-generation cephalosporin antibiotic for parenteral use. It acts bactericidal, disrupting the synthesis of the cell wall of microorganisms.

Has a wide spectrum of activity, is active against: gram-positive bacteria (Staphylococcus spp, Staphylococcus aureus (not producing and producing penicillinase, including Streptococcus pneumoniae), Corynebacterium diphtheriae, Bacillus anthracis, Neuroterium Neisserium microorganis, Neisseria geridii microorganis , Salmonella spp, Escherichia coli, Klebsiella spp, Treponema spp, Leptospira spp) is active against Haemophilus influenzae of some Enterobacter and Enterococcus strains.

Ineffective against: Pseudomonas aeruginosa, indole-positive strains of Proteus spp, Mycobacterium tuberculosis, anaerobic microorganisms, methicillin-resistant strains of Staphylococcus spp.

Indications

- Bacterial infections: upper and lower respiratory tract, urinary and biliary tract, pelvic organs, skin and soft tissues, bones and joints.

- Endocarditis.

- Sepsis.

- Peritonitis.

- Otitis media.

- Osteomyelitis.

- Mastitis.

- Wound, burn, and postoperative infections.

- Syphilis.

- Gonorrhea.

- Other diseases caused by cefazolin-sensitive microorganisms.

- Prevention of surgical infections in the pre- and postoperative period.

Contraindications

- Hypersensitivity to cephalosporins and other beta-lactam antibiotics.

- Pregnancy and lactation.

- If it is necessary to use the drug, breast-feeding is stopped.

- Does not prescribe to newborns (up to 1 month).

Precautions:

- Renal / Hepatic Insufficiency.

- Pseudomembranous enterocolitis.

Use during pregnancy and lactation

Contraindicated in pregnancy and lactation.

Special instructions

Patients who have a history of allergic reactions to penicillins, carbapenems, may be hypersensitive to cephalosporin antibiotics. During treatment with cefazolin, it is possible to obtain positive direct and indirect Coombs samples, as well as a false positive urine reaction to sugar. When prescribing the drug, exacerbation of gastrointestinal diseases, especially colitis, is possible. The safety of use in premature infants and children of the first year of life has not been established.

Composition

1 vial of powder for the preparation of a solution for intravenous and intramuscular administration contains: cefazolin in the form of a sodium salt of 1.0 g.

Dosage and administration

Intravenously, intramuscularly (by stream and by drop). The average daily dose for adults is 1 g, the frequency of administration is 2 times a day. The maximum daily dose is 6 g (in rare cases -12 g), the frequency of administration can be increased up to 3-4 times a day. The average duration of treatment is 7-10 days.

For the prevention of postoperative infection: 30 minutes before surgery, 0.5-1 g. During surgery and 0.5-1 g every 6-8 hours during the day after surgery.

Use in patients with impaired renal function: with a CC of 55 ml / min or more, or with a plasma creatine content of 1.5 mg% or less, a full dose can be administered. With a CC of 54-35 ml / min or with a plasma creatinine content of 3-1.6 mg%, the full dose can be used, but the intervals between injections should be increased to 8 hours. With a CC of 34-11 ml / min or with a creatinine content of 4, 5-3.1 mg% -1 / 2 doses at 12-hour intervals Patients with CC 10 ml / min or less, or with a creatinine content in plasma of 4.6 mg% or more than 1/2 average dose every 18-24 hours.

Use in children: average daily dose for children 20-50 ml / kg in severe infections, the dose can be increased to 100 mg / w / day. The multiplicity of reference is 3-4 times a day.

Use in children with impaired renal function: in children with impaired renal function, correction of the dosage regimen is carried out depending on the QC values. With CC 70-40 ml / min - 60% of the average daily dose and excreted after 12 hours. With CC 40-20 ml / min - 25% of the average daily dose with an interval of 12 hours. Children with CC 5-20 ml / min - 10% of the average daily dose every 24 hours. All recommended doses are administered after the initial loading dose.

Preparation of solutions: for intramuscular administration, the drug is dissolved in 4-5 ml of water for injection, isotonic sodium chloride solution or 0.25-0.5% novocaine solution. For intravenous drip administration, the drug is dissolved in 100-250 ml of isotonic sodium chloride solution or 5% glucose solution, the injection is carried out for 20-30 minutes (injection rate of 60-80 drops per minute). For intravenous jet administration, a single dose of the drug is diluted in 10 ml of isotonic sodium chloride solution and injected slowly over 3-5 minutes. During dilution, the vials are shaken vigorously until completely dissolved.

Drug Interactions

Concomitant use with anticoagulants and diuretics is not recommended. With the simultaneous use of cefazolin and loop diuretics, a blockage of its tubular secretion occurs. Aminoglycosides increase the risk of kidney damage. Pharmaceutically incompatible with aminoglycosides (mutual inactivation). Drugs that block tubular secretion increase blood concentration, slow down excretion, and increase the risk of toxic reactions.

Storage conditions

Store in a dry, dark place at a temperature not exceeding 25 ° C.

Expiration

2 years.

Deystvuyuschee substances

cefazolin

Terms of pharmacy leave

Prescription

Dosage form

solution for injection and infusions

Indications

purulent wounds From skin infections, From otitis media, From sinusitis, Bronchitis, From urinary tract infections, From osteomyelitis, From pneumonia, Purulent-inflammatory diseases skin

Possible product names

cefazolin por. d / pr-r solution for in / ven.and in / mouse.input. vial 1 g

Cefazolin vials 1 g

biosynthesis, biosynthesis



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