Bronchobos syrup 5%, 200 ml (Carbocysteine)

Latin name

Bronchobos

Packing

Bottle 200 ml.

Pharmacological action

Bronchobos is a mucolytic (expectorant) drug.

Pharmacodynamics

Mucolytic and expectorant effect due to the activation of sialic transferase - an enzyme of goblet cells of the bronchial mucosa. It normalizes the quantitative ratio of acidic and neutral sialomucins of bronchial secretion, restores the viscosity and elasticity of mucus.

Promotes the regeneration of the mucous membrane, normalizes its structure, activates the activity of the ciliary epithelium. Restores the secretion of immunologically active IgA (specific protection) and the number of sulfhydryl groups of mucus components (non-specific protection), improves mucociliary clearance.

Pharmacokinetics

Absorption is fast and nearly complete. Bioavailability is low (less than 10% of the dose taken). Tmax in the blood and in the mucous membrane is 1.5–2 hours, the therapeutic concentration remains in the blood for 8 hours. It is retained for the longest time in the blood, liver and middle ear. In high concentration, it accumulates in bronchial secretion (17.5% of the dose taken). It is metabolized in the liver (it has the effect of "first passage" through the liver).

Excreted by the kidneys (60–90% unchanged, the rest - in the form of metabolites). T1 / 2 - 2–3.15 hours. Complete excretion occurs after 3 days.

Indications

acute and chronic bronchopulmonary diseases accompanied by impaired formation and excretion of mucus (tracheitis, bronchitis, tracheobronchitis, bronchial asthma, bronchiectasis)

inflammatory diseases of the middle ear and paranasal sinuses (rhinitis, rhinitis, bronchoscopy or bronchography.

Contraindications

hypersensitivity to the drug or its auxiliary components

peptic ulcer of the stomach and duodenum in the acute stage

chronic glomerulonephritis (in the acute phase)

cystitis srdlp disease liver disease srdlpdp brain disease

pregnancy

lactation.

Precautions: gastric ulcer and duodenal ulcer (history).

Pregnancy and lactation

Pregnancy and lactation are contraindicated.

Composition of

5 ml of syrup contains:

active ingredient: iron (in the form of iron (III) hydroxide polymaltose) 50 mg of

excipients: sucrose, sorbitol, methyl parahydroxybenzoate, ethanol, water, water, ethanol 38 ml of syrup contains:

Active ingredient:

carbocysteine ​​250 mg

Excipients:

glycerol 135 mg

ethanol 96% 125 mg

sodium hydroxide 61 mg

carmellose sodium 20 mg

citric acid monohydrate 10 mg

methyl parahydroxybenzoate 9 mg

sodium saccharin 5 mg

propyl acid (E122) 0.05 mg

purified water - up to 5 ml.

Dosage and Administration

Inside.

Syrup. For the dosage of syrup, a 5 ml volumetric spoon, graduated by 2.5 ml, is used. 1 scoop of syrup 5% (5 ml) = 250 mg carbocysteine ​​1 scoop of syrup 2, 5% (5 ml) = 125 mg carbocysteine.

Adults - 15 ml (3 scoops) 5% syrup 3 times a day.

For children aged 3–6 years, 5 ml each (1 scoop) 2.5% syrup 2–4 times a day. Children over 6 years old - 5-10 ml (1-2 scoops) 2.5% syrup 3 times a day.

Side effects of

From the gastrointestinal tract: nausea, vomiting, diarrhea and epigastric pain, gastrointestinal bleeding are sometimes noted.

Hypersensitivity reaction: isolated cases of allergic reactions (skin itching, urticaria, exanthema, angioedema) have been reported.

Other: dizziness, weakness, malaise.

Overdose

Symptoms: stomach pain, nausea, diarrhea.

Treatment: symptomatic.

Storage conditions

At a temperature of 15 to 30 ° C.

Expiration

3 years.

Dosage form

dosage form

oral solution



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