Arthrosylene capsule with prolonged release of 320 mg 10 pcs. (Ketoprofen)

release form

Capsules



packaging 10 pcs

Pharmacological action

Arthrosilene has anti-inflammatory, analgesic, antipyretic effect.

Indications

relief of pain of mild to moderate intensity, incl. postoperative pains post-traumatic pains and inflammatory pains

rheumatic diseases such as: rheumatoid arthritis

spondylarthritis

osteoarthritis

gouty arthritis

inflammatory lesion of periarticular tissues.

Contraindications

hypersensitivity, including to other NSAIDs

“aspirin” asthma

pregnancy (III trimester)

lactation

peptic ulcer of the stomach and duodenum in the exacerbation phase, peptic ulcer

ulcerative colitis in the exacerbation phase, Crohn's disease

diverticulitis

hemophilia and other blood coagulation disorders

chronic renal failure

children under 18 years of age.

Use during pregnancy and lactation

The use of the drug Arthrosilen in the third trimester of pregnancy is contraindicated. In the first and second trimesters of pregnancy, the drug Arthrosilen should be used with caution and under the supervision of a physician.

If you need to use the drug during lactation, breastfeeding should be discontinued.

Women planning a pregnancy should refrain from taking Arthrosylene, as while taking it, the probability of egg implantation may decrease.

Composition

1 capsule contains ketoprofen lysine salt 320 mg

Dosage and administration

Inside Arthrosilen appoint 1 capsule. per day during or after meals.

Duration of treatment may be 3-4 months.

Side effects

Nervous system: dizziness, hyperkinesia, tremor, vertigo, mood swings, anxiety, hallucinations, irritability, general malaise.

Sensory organs: conjunctivitis, visual impairment.

Skin: urticaria, angioedema, erythematous exanthema, pruritus, maculopapular exanthema, increased sweating, erythema multiforme exudative (including Stevens-Johnson syndrome).

Genitourinary system: painful urination, cystitis, edema, hematuria, menstrual irregularities.

Hematopoietic organs: leukocytopenia, leukocytosis, lymphangitis, decreased PV, thrombocytopenia, thrombocytopenic purpura, enlarged spleen, vasculitis.

Respiratory system: bronchospasm, dyspnea, sensation of laryngeal spasm, laryngospasm, laryngeal edema, rhinitis.

Cardiovascular system: hypertension, hypotension, tachycardia, chest pain, syncope, peripheral edema, pallor.

Allergic reactions: anaphylactoid reactions, swelling of the oral mucosa, swelling of the pharynx, periorbital edema.

Drug Interaction

Inducers of microsomal oxidation in the liver (phenytoin, ethanol, barbiturates, flumecinol, rifampicin, phenylbutazone, tricyclic antidepressants) with concomitant use of the drug Artrozilen increase the metabolism of ketoprofen (increase the production of hydroxylated active metabolites).

On the background of simultaneous use with the drug Artrozilen decreases the effectiveness of uricosuric drugs, increases the effect of anticoagulants, antiplatelet agents, fibrinolytics, ethanol, side effects of mineralocorticoids, glucocorticoids, estrogens, decreases the effectiveness of antihypertensive drugs.

Concurrent use of the drug Artrozilen with other NSAIDs, GCS, ethanol, corticotropin can lead to ulcer formation and the development of gastrointestinal bleeding, to increased risk of kidney dysfunction.

Concurrent use of Artrozilen with oral anticoagulants, heparin, thrombolytics, antiplatelet agents, cefoperazone, cefamandol and cefotethan increase the risk of bleeding.

Artrozilen enhances hypoglycemic action of insulin and oral hypoglycemic agents (dose adjustment is required).

Co-administration of Artrozilen with sodium valproate causes impaired platelet aggregation.

Ketoprofen with concomitant use increases plasma concentrations of verapamil and nifedipine, lithium, methotrexate.

Antacids and cholestyramine, when co-administered with Artrozilen, reduce the absorption of ketoprofen.

Overdose

No cases of overdose with Artrozilen have been reported at this time.

In case of overdose, symptomatic therapy should be performed, monitoring of respiratory and cardiovascular activity. There is no specific antidote. Hemodialysis is ineffective.

Storage conditions

The drug should be stored in a dark place out of the reach of children at temperatures up to 25 ° C.

Expiration

5 years.

Deystvuyuschee substances

Ketoprofen

dosage form

Dosage form

capsules



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