Arpeflu tablets are covered.pl.ob. 50 mg 10 pcs. pack (Metylfenyltyometyl-dymetylamynometyl-hydroksybromyndol karbonovoy acid etylov y ether)

Latin name

ARPEFLU

Release form

tablets

10 pcs 10 pcs Packaging



Pharmacological action of

Antiviral agent, has immunomodulating and anti-influenza effects, specifically inhibits influenza A and B. viruses

Has interferon-inducing properties, stimulates humoral and cellular immunity reactions, increases the ability of macrophages to reactivate macrophages, increases the phagocytic function of viruses. It prevents the development of post-influenza complications, reduces the frequency of exacerbations of chronic diseases, and normalizes immunological parameters. The antiviral effect is due to the suppression of the fusion of the lipid membrane of the virus with cell membranes upon contact of the virus with the cell. Therapeutic efficacy in influenza is manifested in a decrease in intoxication and the severity of catarrhal phenomena, shortening of periods of fever and the overall duration of the disease. Refers to low toxic drugs (LD 50> 4 g / kg). It does not have any negative effects on the human body when administered orally in recommended doses.

Pharmacokinetics

Absorption - fast. It is quickly distributed to organs and tissues. TCmax when taken in a dose of 50 mg - 1.2 hours, 100 mg - 1.5 hours. It is metabolized in the liver. T1 / 2 - 17-21 hours. About 40% is excreted unchanged, mainly with bile (38.9%) and in a small amount by the kidneys (0.12%). During the first day, 90% of the administered dose is excreted.

Indications

Prevention and treatment in adults and children: influenza A and B viruses caused by

acute respiratory viral infections (SARS) (including those complicated by bronchitis, pneumonia)

secondary immunodeficiency states.

Complex therapy of chronic bronchitis, pneumonia and recurrent herpetic infection.

Prevention of postoperative infectious complications and normalization of immune status in adults.

Contraindications

childhood (up to 3 years)

the presence of diseases such as galactose intolerance, lactase deficiency, glucose-galactose malabsorption

hypersensitivity to the drug.

Special instructions

It does not exhibit central neurotropic activity and can be used in medical practice as a preventive measure in healthy individuals of various professions, including those requiring increased attention and coordination of movements (transport drivers, operators, etc.).

Composition

1 tablet contains:

Active ingredient: 6-bromo-5-hydroxy-1-methyl-4-dimethylaminomethyl-2-phenylthiomethylindole-3-carboxylic acid ethyl ester hydrochloride monohydrate

Dosage and administration

Inside, before meals. Single dose: for children from 3 to 6 years old - 50 mg, from 6 to 12 years old - 100 mg, over 12 years old and adults - 200 mg (2 tablets of 100 mg or 4 tablets of 50 mg).

For non-specific prophylaxis of

In direct contact with patients with influenza and other acute respiratory viral infections: children from 3 to 6 years old - 50 mg, from 6 to 12 years old - 100 mg, over 12 years old and adults - 200 mg 1 time per day for 10-14 days.

During the period of the epidemic of influenza and other acute respiratory viral infections, to prevent exacerbations of chronic bronchitis, relapse of herpetic infection: children from 3 to 6 years old - 50 mg, from 6 to 12 years old - 100 mg, older than 12 years old and adults - 200 mg 2 times a week for 3 weeks.

Prevention of postoperative complications: children from 3 to 6 years old - 50 mg, from 6 to 12 years old - 100 mg, over 12 years old and adults - 200 mg 2 days before surgery, then on 2 and 5 days after surgery.

For the treatment of

Influenza, other acute respiratory viral infections without complications: children from 3 to 6 years old - 50 mg, from 6 to 12 years old - 100 mg, over 12 years old and adults - 200 mg 4 times a day (every 6 hours) for 5 days.

Influenza, other acute respiratory viral infections with the development of complications (bronchitis, pneumonia and others): children from 3 to 6 years old - 50 mg, from 6 to 12 years old - 100 mg, over 12 years old and adults - 200 mg 4 times a day (every 6 hours) for 5 days, then a single dose 1 time per week for 4 weeks.

Side effects

Allergic reactions.

Storage conditions

At a temperature not exceeding 25 ° C. Out of the reach of children.

Term hodnosty

2 years

Deystvuyuschee substances

Metylfenyltyometyl-dymetylamynometyl-hydroksybromyndol karbonovoy acid эtylov y ether

Form of Treatment

tablets

Indications

SARS, Influenza, Prevention of influenza and colds, shingles, cold, herpes

Possible product names

Arpeflu tablets coated film 50 mg 10 pcs.

Lekpharm, Russia



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