AnviMax Raspberry sachets 5 g, 3 pcs. (Paracetamol, ascorbic acid, rimantadine, Rutozyd, loratadine, calcium gluconate)

Latin name

ANVIMAX

Release form powder

Powder for preparation of solution for oral administration 5 g, 3 sachets

Packaging

5 g - heat-sealing bags (3) - packs of cardboard.

Pharmacological action

Pharmacotherapeutic group

acute respiratory infections and "colds" symptoms remedy.

ATX code: R05X

Pharmacodynamics

Combined drug with antiviral, interferonogenic, antipyretic, analgesic, antihistamine and angioprotective effects.

Paracetamol has an analgesic and antipyretic effect.

Ascorbic acid is involved in the regulation of redox processes, promotes normal capillary permeability, blood coagulation, tissue regeneration, plays a positive role in the development of the body's immune responses, replenishes vitamin C deficiency.

Calcium gluconate, as a source of calcium ions, prevents the development of increased permeability and fragility of blood vessels causing hemorrhagic processes in influenza and acute respiratory viral infection (ARVI), has an anti-allergic effect (the mechanism is unclear).

Rimantadine has antiviral activity against influenza A virus. By blocking the M2 channels of influenza A virus, it disrupts its ability to penetrate cells and release ribonucleoprotein, thereby inhibiting the most important stage of virus replication. Induces the production of interferons alpha and gamma. In influenza caused by virus B, rimantadine has an antitoxic effect.

Rutoside is an angioprotector. Reduces capillary permeability, swelling and inflammation, strengthens the vascular wall. It inhibits aggregation and increases the degree of deformation of red blood cells.

Loratadine - a blocker of H1-histamine receptors, prevents the development of tissue edema, associated with the release of histamine.

Indications

Etiotropic treatment for type A flu, symptomatic treatment of colds, influenza and SARS, accompanied by fever, muscle pain, headache, chills in adults.

Contraindications

Hypersensitivity to one or more of the components of the preparation erosive-ulcerative lesions of the gastrointestinal tract in the acute phase gastrointestinal hemorrhage hemorrhagic diathesis hypoprothrombinemia maternal hypertension and maternal obesity kidney and liver diseases (acute glomerulonephritis, acute pyelonephritis, acute hepatitis, or exacerbation of chronic diseases of these organs) chronic alcoholism hypercalcemia, severe hypercalciuria, nephrourolithiasis, sarcoidosis, concomitant use of cardiac glycosides (risk of arrhythmias) lactose intolerance, lactase deficiency, glucose-galactose malabsorption of phenylketonuria. Children under 18 years old.

Precautions

Restriction of use in epilepsy, cerebral atherosclerosis, diabetes mellitus, glucose-6-phosphate dehydrogenase deficiency, hemochromatosis, sideroblastic anemia, thalassemia, hyperoxaluria, kidney stone disease, dehydration, electrolyte dyslipidemia, calyre diacetosis, malolecitis, malignancy, and calving nephrourolithiasis (history), hypercalciuria.

Elderly patients with arterial hypertension (increased risk of hemorrhagic stroke, due to the part of the drug rimantadine).

Pregnancy and lactation

Pregnancy and lactation are contraindicated.

Composition

Active ingredients: paracetamol - 360 mg, ascorbic acid - 300 mg, calcium gluconate monohydrate - 100 mg, rimantadine hydrochloride - 50 mg, rutoside trihydrate (in terms of rutoside) - 20 mg, loratadine: 3 mg excipients aspartame - 30 mg, hypromellose - 10 mg, colloidal silicon dioxide - 20 mg, lactose monohydrate - 4086 mg, food flavoring (lemon or lemon and honey, or raspberry, or black currant) - 21 mg.

Dosage and Administration

Inside.

Dissolve the contents of one sachet in half a glass of boiled warm water. Use immediately after dissolution. Stir the solution before use. Adults: take 1 sachet 2-3 times a day after meals for 3-5 days (no more than 5 days) until the symptoms disappear.

If there is no improvement in well-being, you should stop taking the drug and consult a doctor.

Side effects

According to the ingredients.

From the central nervous system. Increased irritability, drowsiness, tremors, hyperkinesia, dizziness, headache, flushing of the face. From the digestive system. Damage to the mucous membrane of the stomach and duodenum, dyspepsia, dry mucous membrane in the mouth, lack of appetite, bloating (flatulence), diarrhea (diarrhea).

From the urinary system. Moderate pollakiuria.

From the side of the blood. Changes in blood counts. Control needed.

Others. Inhibition of the function of the insular apparatus of the pancreas (hyperglycemia, glucosuria).

Allergic reactions. Skin rash, itching, urticaria.

If any of the side effects indicated in the instructions are aggravated, or you notice any other side effects not listed in the instructions, inform your doctor immediately.

Drug Interaction

Paracetamol reduces the effectiveness of uricosuric drugs. Concomitant use of paracetamol in high doses increases the effect of anticoagulant drugs. Inductors of microsomal oxidation in the liver (phenytoin, barbiturates, rifampicin, phenylbutazone, tricyclic antidepressants), ethanol and hepatotoxic drugs increase the production of hydroxylated active metabolites, which causes the possibility of severe intoxications even with excessive toxicity. When co-administered with metoclopramide, an increase in the suction rate of paracetamol is possible. Prolonged use of barbiturates reduces the effectiveness of paracetamol. Microsomal oxidation inhibitors reduce the risk of hepatotoxic action.

Rimantadine enhances the excitatory effect of caffeine. Cimetidine reduces the clearance of rimantadine by 18%.

Ascorbic acid increases the blood concentration of benzylpenicillin. Improves absorption of iron preparations in the intestine (converts trivalent iron into divalent) can increase iron excretion when used simultaneously with deferx-samin. Increases the risk of crystalluria when treated with short-acting salicylates and sulfanilamides, slows the elimination of kidney acids, increases the excretion of drugs that have an alkaline reaction (including alkaloids). Reduces blood concentration of oral contraceptives. Increases the overall clearance of ethanol, which in turn reduces the concentration of ascorbic acid in the body. When used concurrently, it reduces the chronotropic effect of isoprenaline. Barbiturates and primidone increase the excretion of ascorbic acid in the urine. Reduces the therapeutic effect of antipsychotic drugs (neuroleptics) - phenothiazine derivatives, tubular reabsorption of amphetamine and tricyclic antidepressants.

Loratadine. CYP3A4 and CYP2D6 inhibitors increase the concentration of loratadine in the blood.

Overdose

Symptoms: within the first 24 hours after ingestion - paleness of the skin, nausea, diarrhea, vomiting, epigastric pain, metabolic acidosis, tachycardia, arrhythmia, headache, exacerbation. Symptoms of liver dysfunction may occur 12-48 hours after overdose. In severe overdose - hepatic failure with progressive encephalopathy, coma acute renal failure with tubular necrosis (including in the absence of severe liver damage).

Treatment: introduction of donors of SH-groups and precursors of synthesis of glutathione - methionine within 8-9 h after overdose and acetylcysteine ​​- within 8 h. Gastric lavage, symptomatic therapy. The need for additional therapeutic measures (further administration of methionine, acetylcysteine) is determined depending on the concentration of paracetamol in the blood, as well as the time elapsed after its administration.

Storage conditions

The drug should be stored in a dry place inaccessible to children at a temperature not exceeding 25 ° C.

Expiration

2 years.

Active ingredient

Paracetamol, Ascorbic acid, Rome tadyn, Rutozyd, loratadine, calcium gluconate

Dosage form

dosage form

oral solution

FarmVILAR FPK, Russia



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