AnviMax pore. d / prigot. r-ra d / int. taking 5g sachet No. 6 (lemon)

Package quantity 6 Dosage form oral solution Composition 1 pack: - paracetamol 360 mg - ascorbic acid 300 mg - calcium gluconate monohydrate 100 mg - rimantadine hydrochloride 50 mg - rutoside (in the form of trihydrate) 20 mg - loratadine 3 mg Excipients : aspartame - 30 mg, hypromellose - 10 mg, colloidal silicon dioxide - 20 mg, lactose monohydrate - 4086 mg, food flavoring (lemon or lemon with honey, or raspberry, or black currant) - 21 mg

Pharmacological action Anvimax has anesthetic, antihistamine, angioprotective, antipyretic, antiviral effect

Combined drug, has antiviral, interferonogenic, antipyretic, analgesic, antihistamine and angioprotective effect due to its active ingredients: Paracetamol - analgesics and antipyretic

Ascorbic acid is involved in the regulation of redox processes, contributes to normal capillary permeability, blood clotting, tissue regeneration, plays a positive role in the development of the body's immune reactions, replenishes vitamin C deficiency

Calcium gluconate, as a source of calcium ions, prevents the development of increased permeability and fragility of blood vessels that cause hemorrhagic processes in influenza and ARVI, has an anti-allergic effect (the mechanism is unclear)

Rimantadine has antiviral activity against influenza A. By blocking the M2 channels of influenza A virus, it disrupts its ability to penetrate cells and release ribonucleoprotein, thereby inhibiting the most important stage of viral replication.

Induces the production of alpha and gamma interferons.

In influenza caused by virus B, rimantadine has an antitoxic effect

Rutoside is an angioprotective agent.

Reduces capillary permeability, swelling and inflammation, strengthens the vascular wall.

Inhibits aggregation and increases the degree of deformation of erythrocytes

Loratadine - a blocker of H1-histamine receptors, prevents the development of tissue edema associated with the release of histamine

Paracetamol. Absorption is high. Communication with plasma proteins - 15%. Penetrates the BBB. It is metabolized in the liver through three main pathways: conjugation with glucuronides, conjugation with sulfates, oxidation by microsomal liver enzymes. In the latter case, toxic intermediate metabolites are formed, which are subsequently conjugated with glutathione, and then with cysteine ��and mercapturic acid. The main cytochrome P450 isoenzymes for this metabolic pathway are CYP2E1 isoenzymes (predominantly), CYP1A2 and CYP3A4 (minor role). When glutathione is deficient, these metabolites can cause damage and necrosis of hepatocytes. Additional metabolic pathways are hydroxylation to 3-hydroxyparacetamol and methoxylation to 3-methoxyparacetamol, which are subsequently conjugated to glucuronides or sulfates.In adults, glucuronidation predominates. Conjugated paracetamol metabolites (glucuronides, sulfates and conjugates with glutathione) have low pharmacological (including toxic) activity. It is excreted by the kidneys in the form of metabolites, mainly conjugates, only 3% unchanged. In elderly patients, drug clearance decreases and T1 / 2 increases

According to the results of clinical studies, the following pharmacokinetic parameters of paracetamol were established: Cmax in blood plasma is achieved when the powder is applied after (0.7 В± 0.39) h and is (4.79 В± 1.81) Ојg / ml, T1 / 2 is ( 2.73 В± 0.76) h

Cmax in blood plasma is achieved with the use of capsules after (1.2 В± 0.72) h and is (5.01 В± 1.7) Ојg / ml, T1 / 2 is (3.04 В± 1.01) h

Ascorbic acid is absorbed in the gastrointestinal tract (mainly in the jejunum).

Connection with plasma proteins - 25%.

Diseases of the gastrointestinal tract (peptic ulcer of the stomach and duodenum, constipation or diarrhea, helminthic invasion, giardiasis), the use of fresh fruit and vegetable juices, alkaline drinks reduce absorption

Dosage

etc.

x 5g

Structure

1 pack .: - paracetamol 360 mg - ascorbic acid 300 mg - calcium gluconate monohydrate 100 mg - rimantadine hydrochloride 50 mg - rutoside (in the form of trihydrate) 20 mg - loratadine 3 mg Excipients: aspartame - 30 mg, hypromellose - 10 mg, colloidal silicon dioxide - 20 mg, lactose monohydrate - 4086 mg, food flavoring (lemon or lemon with honey, or raspberries, or black currant) - 21 mg.

Storage conditions and periods

In a dry place, at a temperature not exceeding 25 degrees.

INN / Active ingredient

loratadine + rutoside + rimantadine hydrochloride + calcium gluconate monohydrate + ascorbic acid + paracetamol

Specifications

Category

Pain and fever

Scope of the drug

General

Dosage (volume) of the substance in the preparation

5 g

Release form

Filter package

Manufacturer country

Russia

Package quantity, pcs

6

Way of introduction

Through the mouth

Vacation conditions

Without recipe

Brand name

PharmVILAR

The amount of the dosage form in the primary package

5 g

Primary packaging type

Sachet (sachet)

Type of consumer packaging

Pack of cardboard

Pharmaco-therapeutic group

ARI and cold" symptoms remedy

Expiration date in days

912

A type

Medicine

The target audience

Adult

Package weight, g

fifty

Mode of application

:

Inside - Dissolve the contents of one sachet in half a glass of boiled warm water.

Consume immediately after dissolving.

Stir the solution before use.

Adults: take 1 sachet 2-3 times a day after meals for 3-5 days (no more than 5 days) until the symptoms of the disease disappear < br> If you do not feel better, you should stop taking the drug and consult a doctor.

Anatomical and therapeutic characteristics

:

R05X Preparations for the elimination of cold symptoms in combination with others

Dosage form

:

Powder for oral solution [lemon]

Information on technical characteristics, delivery set, country of manufacture "