AnviMax Lemon with honey sachets 5 g, 24 pcs. (Paracetamol , Ascorbic acid, Rimantadine, Rutoside, Loratadine, Calcium gluconate)

Release form

Powder for oral solution

Packing

24 pcs.

Pharmacological action

Pharmacotherapeutic group

acute respiratory infections and "colds" symptoms remedy.

ATX code: R05X

Pharmacodynamics

Combined drug with antiviral, interferonogenic, antipyretic, analgesic, antihistamine and angioprotective effects.

Paracetamol has an analgesic and antipyretic effect.

Ascorbic acid is involved in the regulation of redox processes, contributes to normal capillary permeability, blood coagulation, tissue regeneration, plays a positive role in the development of the body's immune responses, replenishes vitamin C deficiency.

Calcium gluconate, as a source of calcium ions, it prevents the development of increased permeability and fragility of blood vessels, causing hemorrhagic processes in influenza and acute respiratory viral infection (ARVI), has an antiallergic effect (the mechanism is unclear).

Rimantadine has antiviral activity against influenza A virus. By blocking the M2 channels of influenza A virus, it disrupts its ability to penetrate cells and release ribonucleoprotein, thereby inhibiting the most important stage of virus replication. Induces the production of interferons alpha and gamma. In influenza caused by virus B, rimantadine has an antitoxic effect.

Rutoside is an angioprotector. Reduces capillary permeability, swelling and inflammation, strengthens the vascular wall. It inhibits aggregation and increases the degree of deformation of red blood cells.

Loratadine - a blocker of H1-histamine receptors, prevents the development of tissue edema associated with the release of histamine.

Indications

Etiotropic treatment for type A flu, symptomatic treatment of colds, flu and SARS, accompanied by fever, muscle pain, headache, chills in adults.

Contraindications

Hypersensitivity to one or more components, erosive and ulcerative lesions of the gastrointestinal tract in the acute phase gastrointestinal bleeding hemophilia hemorrhagic diathesis hypoprothrombinemia portal hypertension avitaminosis K renal failure pregnancy, period of breastfeeding thyroid disease, acute kidney disease, liver disease (acute glomerulone acute hepatitis, or exacerbation of chronic diseases of these organs) chronic alcoholism hypercalcemia, severe hypercalce Iuria, nephrourolithiasis, sarcoidosis, concomitant use of cardiac glycosides (risk of arrhythmias) lactose intolerance, lactase deficiency, glucose-galactose malabsorption of phenylketonuria. Children under 18 years old.

Precautions

Limitation of use in epilepsy, cerebral atherosclerosis, diabetes mellitus, deficiency of glucose-6-phosphate dehydrogenase, hemochromatosis, sideroblastic anemia, thalassemia, hyperoxaluria, kidney stone disease, dehydration, electrolyte disturbances (risk of hypercalcemia), diarrhea, malabserousia syndrome, calcium malabsorption, calcium malabsorption, calcium.

Elderly patients with arterial hypertension (increased risk of hemorrhagic stroke due to rimantadine, which is part of the drug).

Special instructions

Duration of use - no more than 5 days.

Do not use if metastatic tumors are present.

Persons prone to ethanol should consult a doctor before starting treatment with the drug, since paracetamol can have a damaging effect on the liver.

Influence on the ability to drive vehicles and other mechanisms requiring increased concentration of attention

During treatment, care must be taken when driving vehicles and engaging in other potentially dangerous activities that require increased concentration of attention and speed of psychomotor reactions.

Composition

Active ingredients: paracetamol - 360 mg, ascorbic acid - 300 mg, calcium gluconate monohydrate - 100 mg, rimantadine hydrochloride - 50 mg, rutoside trihydrate (in terms of rutoside) - 20 mg, loratadine - 3 mg excipients: aspartame - 30 mg, hypromellose - 10 mg, colloidal silicon dioxide - 20 mg, lactose monohydrate - 4086 mg, food flavoring (lemon or lemon and honey, or raspberry, or black currant) - 21 mg.

Dosage and Administration

Inside.

Dissolve the contents of one sachet in half a glass of boiled warm water. Use immediately after dissolution. Stir the solution before use. Adults: take 1 sachet 2-3 times a day after meals for 3-5 days (no more than 5 days) until the symptoms disappear.

If there is no improvement in well-being, you should stop taking the drug and consult a doctor.

Side effects

According to the ingredients.

From the central nervous system. Increased irritability, drowsiness, tremors, hyperkinesia, dizziness, headache, flushing of the face. From the digestive system. Damage to the mucous membrane of the stomach and duodenum, dyspepsia, dry mucous membrane in the mouth, lack of appetite, bloating (flatulence), diarrhea (diarrhea).

From the urinary system. Moderate pollakiuria.

From the side of the blood. Changes in blood counts. Control needed.

Others. Inhibition of the function of the insular apparatus of the pancreas (hyperglycemia, glucosuria).

Allergic reactions. Skin rash, itching, urticaria.

If any of the side effects indicated in the instructions are aggravated, or you notice any other side effects not listed in the instructions, inform your doctor immediately.

Drug Interactions

Paracetamol reduces the effectiveness of uricosuric drugs. The concomitant use of paracetamol in high doses increases the effect of anticoagulant drugs. Inducers of microsomal oxidation in the liver (phenytoin, barbiturates, rifampicin, phenylbutazone, tricyclic antidepressants), ethanol and hepatotoxic drugs increase the production of hydroxylated active metabolites, which makes it possible to develop severe intoxications even with a small overdose. With simultaneous use with metoclopramide, an increase in the rate of absorption of paracetamol is possible. Prolonged use of barbiturates reduces the effectiveness of paracetamol. Microsomal oxidation inhibitors reduce the risk of hepatotoxicity.

Rimantadine enhances the stimulating effect of caffeine. Cimetidine reduces the clearance of rimantadine by 18%.

Ascorbic acid increases the concentration of benzylpenicillin in the blood. It improves the absorption of iron preparations in the intestines (converts ferric to ferrous) and can increase iron excretion while it is used with deferkamine. Increases Chris Risk It improves the absorption of iron preparations in the intestines (converts ferric to ferrous) and can increase iron excretion while it is used with deferkamine. Increases Chris Risk It improves the absorption of iron preparations in the intestines (converts ferric to ferrous) and can increase iron excretion while it is used with deferkamine. Increases Chris RiskTalluria in the treatment of short-acting salicylates and sulfonamides, slows down the excretion of acids by the kidneys, increases the excretion of drugs with an alkaline reaction (including alkaloids). Reduces the blood concentration of oral contraceptives. Increases the total clearance of ethanol, which in turn reduces the concentration of ascorbic acid in the body. With simultaneous use, it reduces the chronotropic effect of isoprenaline. Barbiturates and primidone increase urinary excretion of ascorbic acid. Reduces the therapeutic effect of antipsychotic drugs (antipsychotics) - phenothiazine derivatives, tubular reabsorption of amphetamine and tricyclic antidepressants.

loratadine. CYP3A4 and CYP2D6 inhibitors increase the concentration of loratadine in the blood.

Overdose

Symptoms: during the first 24 hours after administration - pallor of the skin, nausea, diarrhea, vomiting, pain in the epigastric region, impaired glucose metabolism, metabolic acidosis, tachycardia, arrhythmia, headache, exacerbation of concomitant chronic diseases. Symptoms of impaired liver function may appear 12-48 hours after an overdose. In severe overdose - liver failure with progressive encephalopathy, coma, acute renal failure with tubular necrosis (including in the absence of severe liver damage).

Treatment: the introduction of SH-group donors and precursors of glutathione synthesis - methionine for 8-9 hours after an overdose and acetylcysteine ​​- for 8 hours. Gastric lavage, symptomatic therapy. The need for additional therapeutic measures (further administration of methionine, acetylcysteine) is determined depending on the concentration of paracetamol in the blood, as well as on the time elapsed after its administration.

Storage conditions

In a dry place, at a temperature not exceeding 25 ° C.

Dosage for

oral solution

Appointment

For Adults

Possible product names

ANVIMAX N24 PACK POR D / R-RA / LEMON-MED

AnviMax Lemon with honey sachets 5 g, 24 pcs.

AnviMax por 5g pack x 24 lemon / honey

AnviMax por 5g pack x24 lemon

AnviMax por d / r d / inside approx 5g pack N24 lemon with honey

FarmVILAR FPK, Russia



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