Amoxiclav Quicktab dispersible tablets 500 mg + 125 mg 14 pcs. (Amoxicillin, clavulanic acid)

Release form

Dispersible tablets

Packing

14 pcs.

Pharmacological action

Amoxiclav Quicktab - a broad-spectrum antibiotic contains semisynthetic penicillin amoxicillin and a b-lactamase clavulanic acid inhibitor. Clavulanic acid inhibits most clinically significant b-lactamases (types 2, 3, 4 and 5 according to the classification of Richmond Sykes) produced by Staphylococcus spp., Escherichia coli, Proteus mirabilis, Haemophilus influenzae, Moraxella catarrhalis, Bacteroides spp. Inactive against type 1 b-lactamases produced by Enterobacter spp., Morganella morganii, Pseudomonas aeruginosa, Serratia spp., Acinetobacter spp.

This combination provides high bactericidal activity of Amoxiclav (including against strains of microorganisms resistant to amoxicillin). Clavulanic acid, having a higher affinity for b-lactamase than amoxicillin, forms a stable deactivated complex with the enzyme, preventing the enzymatic degradation of amoxicillin under the action of b-lactamases.

Thus, Amoxiclav acts bactericidal on a wide range of gram-positive and gram-negative bacteria (including strains that have become resistant to beta-lactam antibiotics due to the production of b-lactamases).

Indications

Treatment of infectious and inflammatory diseases caused by microorganisms sensitive to the drug: - infections of the upper respiratory tract and ENT organs (including acute and chronic sinusitis, acute and chronic otitis media, pharyngeal abscess, tonsillitis, pharyngitis) srdlp - infections of the lower respiratory tract (including acute bronchitis with bacterial superinfection, chronic bronchitis, pneumonia)

- urinary tract infections

- gynecological infections

- infections of the skin and soft tissues

- infections of the bones and joints

- infections of the biliary tract (cholecystitis, cholangitis)

- odontogenic infections.

Contraindications

- cholestatic jaundice or liver dysfunction caused by the administration of amoxicillin / clavulanic acid in the history of

- hypersensitivity to amoxicillin, clavulanic acid or penicillins.

With caution, the drug should be prescribed for allergic reactions to cephalosporins and pseudomembranous colitis in the anamnesis, liver failure, severe renal impairment.

Due to the fact that in a large number of patients with infectious mononucleosis and lymphocytic leukemia who received ampicillin, the appearance of an erythematous rash was observed, the use of ampicillin antibiotics in such patients is not recommended.

Use during pregnancy and lactation

Amoxicillin and clavulanic acid pass into breast milk in small amounts.

Amoxiclav can be used during pregnancy if the expected benefit to the mother outweighs the potential risk to the fetus.

Special instructions

During the course of treatment, the function of hematopoiesis, liver and kidneys should be monitored.

Patients with severe renal impairment require adequate dosage adjustment or increased dosing intervals.

In order to reduce the risk of adverse reactions from the gastrointestinal tract, the drug should be taken with meals.

When using Amoxiclav, a false-positive reaction is possible when determining the level of glucose in the urine when using Benedict's reagent or Felling's solution (enzymatic reactions with glucose oxidase are recommended).

Concurrent administration with disulfiram should be avoided.

Composition

1 tablet (625 mg) contains amoxicillin (as a trihydrate) 500 mg and clavulanic acid (as potassium salt) 125 mg

Dosage and administration

Amoxiclav Quiktab tablets are taken by mouth, previously dissolved in half a glass of water (at least 30 ml) and mixed thoroughly. It is possible to hold the tablets in the mouth until completely dissolved, and then swallow. In order to reduce the risk of side effects from the gastrointestinal tract, the drug should be taken at the beginning of a meal.

Adults and children over 12 years of age (body weight> 40 kg) with mild or moderate infection are prescribed 1 tablet (625 mg) every 12 hours, in case of severe infection and respiratory tract infections - 1 tablet (625 mg) every 8 hours or 1 tablet (1000 mg) every 12 hours

Duration of treatment - up to 14 days.

If treatment is started with parenteral administration, Amoxiclav Quicktab tablets may be continued.

In accordance with the severity of functional renal impairment, the dose of the drug should be reduced and / or the interval of use should be increased. For moderate renal failure (CC 10-30 ml / min), 1 tablet (625 mg) is prescribed every 12 hours. For severe renal failure (CC

Side effects of the

From the digestive system: possible loss of appetite, nausea, vomiting, diarrhea rarely - a transient increase in the activity of liver enzymes (ALT, AST), impaired liver function in isolated cases - cholestatic jaundice, hepatitis, pseudomembranous colitis.

Allergic reactions: erythematous rash, pruritus, urticaria, rarely - multiforme exudative erythema, angioedema, anaphylactic shock in isolated cases - exfoliative dermatitis, Stevens-Johnson syndrome.

Other: rarely - development of superinfection, candidiasis.

Drug interaction

With the simultaneous use of Amoxiclav and indirect anticoagulants, an increase in prothrombin time is noted. Therefore, this combination is prescribed with caution.

With the simultaneous use of Amoxiclav with allopurinol, the risk of developing side effects such as exanthema increases.

With the simultaneous use of Amoxiclav enhances the toxicity of methotrexate.

The combination of amoxicillin with rifampicin is antagonistic (there is a mutual weakening of the antibacterial effect).

Amoxiclav should not be used simultaneously with bacteriostatic antibiotics (macrolides, tetracyclines), sulfonamides due to a possible decrease in the effectiveness of Amoxiclav.

With the simultaneous use of Amoxiclav reduces the effectiveness of oral contraceptives.

Overdose

Symptoms: abdominal pain, diarrhea, vomiting may also cause anxiety, insomnia, dizziness in some cases - convulsions.

Treatment: in case of recent administration of the drug (less than 4 h) it is necessary to carry out gastric lavage and appoint activated charcoal to reduce the absorption of the drug, if necessary, carry out symptomatic therapy. Hemodialysis is effective.

Storage conditions

The product should be stored in a dry, out of the reach of children at a temperature not exceeding 25 ° C.

Shelf life

2 years.

Deystvuyushtee substance

amoxicillin, Klavulanovaya Chisloth

Terms and conditions

prescription

dosage form

tablets soluble



Appointment Appointment

lactating mothers prescribed by a doctor, prescribed by a doctor Children, pregnant by a doctor, Children older than 12 years, For adults as prescribed by a doctor



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