Aminocaproic acid vials 5%, 100 ml (Amynokapronovaya acid)

Latin name

Aminocaproic acid

Release form

Solution for infusion 5%

Packing

Bottle 100 ml.

Pharmacological action

Aminocaproic acid - a hemostatic agent, fibrinolysis inhibitor. It blocks the action of plasminogen activators, inhibits the action of plasmin, partially inhibits kinins. Aminocaproic acid also has some anti-allergic activity and slightly increases the antitoxic function of the liver.

Indications

For stopping bleeding during surgical interventions and various pathological conditions, accompanied by increased fibrinolytic activity of blood and tissues (after operations on the lungs, prostate, pancreas and thyroid gland). Prevention of the development of secondary hyperfibrinogenemia with massive transfusions of canned blood.

Contraindications

hypersensitivity

hypercoagulation (thrombosis, thromboembolism)

tendency to thrombosis and thromboembolic diseases

cerebrovascular accident

DBC pregnancy syndrome.

Caution:

arterial hypotension

valvular heart disease

insufficiency

CRF.

Use during pregnancy and lactation

Contraindicated in pregnancy and lactation.

Composition

1 ml contains: aminocaproic acid 50 mg.

Dosage and administration

Aminocaproic acid solution is administered intravenously.

For adults, the drug is administered intravenously in the form of a 5% solution in an amount up to 100 ml dropwise at a rate of 50-60 drops per minute (for 15-30 minutes). During the first hour, it is recommended to introduce 4-5 g (80-100 ml) of the drug, and then, if necessary, 1 g (20 ml) every hour for about 8 hours or until the bleeding stops completely. In case of ongoing or repeated bleeding, injections of a 5% aminocaproic acid solution are repeated every 4 hours.

The administration of an aminocaproic acid solution can be combined with an infusion of glucose solution, hydrolysates and anti-shock solutions. In acute fibrinolysis, when the content of fibrinogen in the blood drops sharply, the introduction of aminocaproic acid must be supplemented by a subsequent infusion of fibrinogen.

Side effects

dizziness

headache

tinnitus,

nausea

diarrhea

nasal congestion

skin rash

decreased blood pressure

orthostatic hypotension

cramps

rhabdomyolysis

myoglobinuria

acute renal failure sardlkpardis

Drug Interaction

May be combined with administration of hydrolysates, glucose solutions (dextrose solutions), anti-shock solutions. In acute fibrinolysis, the introduction of aminocaproic acid with a fibrinogen content of 2-4 g (maximum - 8 g) should be supplemented with a subsequent infusion.

Anti-aggregate reduction with simultaneous administration of direct and indirect anticoagulants.

No medicines should be added to the aminocaproic acid solution.

Overdose

Increased side effects (dizziness, nausea, diarrhea, upper respiratory tract catarrh) and severe suppression of fibrinolysis.

In cases of overdose, plasminogen activators (streptokinase, urokinase or anistreptase) should be given urgently.

Storage conditions

Dry, protected from light and inaccessible to children, at a temperature not exceeding 25 ° C.

The Expiration of

is 3 years.

Deystvuyuschee substances

Amynokapronovaya acid



pharmacy terms and conditions prescription

Krasfarma, Russia



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