Albarel tablets 1 mg, 30 pcs. (Rilmenidine)

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Latin name

Albarel Buy Albarel tablets 1 mg, 30 pcs. (Rilmenidine) in florida free shipping. Fast international shipping USA, AU, EU, UK and others.
Latin name

Albarel

Release form

Tablets.

Packaging

In a blister pack of 10 tablets. There are 3 blisters in the package.

Pharmacological action

Albarel is an antihypertensive drug derived from oxazoline.

Selectively interacts with imidazoline receptors (I 1) of cortical and peripheral vasomotor centers, in particular renal centers. The binding of rilmenidine with imidazoline receptors inhibits the sympathomimetic activity of both cortical and peripheral centers, which leads to a decrease in blood pressure.

Albarel has a dose-dependent hypotensive effect on systolic and diastolic blood pressure in the supine and standing position. It has been shown that the administration of the drug Albarel in therapeutic doses (1 or 2 mg / day) is effective in the treatment of mild to moderate arterial hypertension. The effect of the drug persists for 24 hours, effective during physical exertion. With prolonged use, addiction does not develop.

In therapeutic doses, Albarel does not affect the function of the heart, does not cause a delay in sodium and water, and does not upset the metabolic balance.

Albarel reduces OPSS without changing cardiac output. Myocardial contractility and electrophysiological indices remain unchanged.

Albarel does not cause orthostatic hypotension (including in the elderly) does not violate the compensatory physiological response of the heart rhythm to physical activity does not affect renal blood flow, glomerular filtration or filtration fraction does not affect carbohydrate and lipid metabolism (including in patients with insulin-dependent and non-insulin-dependent diabetes mellitus).

Indications

Arterial hypertension

Contraindications

Severe depression.

Severe renal failure (creatinine clearance <15 ml / min).

Pregnancy.

Lactation (breastfeeding).

Hypersensitivity to the drug.

Use during pregnancy and lactation

The drug should not be prescribed during pregnancy and during lactation (breastfeeding) due to the lack of sufficient clinical data.

In experimental studies, no teratogenic and embryotoxic effects were observed.

Composition

1 tablet contains:

active ingredient: drotaverina hydrochloride 40.0 mg

excipients: lactose monohydrate, microcrystalline cellulose, corn starch, croscarmellose sodium, silicon colloidal anhydrous, 1 tablet 4 :

Active ingredients

Rilmenidine 1 mg.

Excipients

Sodium carboxymethyl starch, microcrystalline cellulose, lactose, paraffin, silicon anhydrous colloidal dioxide, magnesium stearate, talc, white beeswax.

Dosage and Administration

The recommended dose of Albarel is 1 mg / day (1 tab.) in the morning.

If blood pressure does not decrease enough after one month of treatment, the dose can be increased to 2 mg / day in 2 divided doses (1 tablet in the morning and 1 tablet in the evening with meals).

In patients with mild to moderate renal failure (creatinine clearance greater than 15 ml / min), dose adjustment is not required.

Treatment is carried out for a long time.

Side effects

Side effects are rare, usually mild and transient.

From the side of the central nervous system

Asthenia, insomnia, drowsiness, increased fatigue during physical exertion are possible in isolated cases - anxiety, depression, cramps.

From the side of the cardiovascular system

Perhaps a heartbeat in isolated cases - cold extremities, orthostatic hypotension.

From the digestive system

Possible pain in the epigastrium, dry mouth, diarrhea in isolated cases - nausea, constipation.

Dermatological reactions

Rarely - skin rash, itching.

Other

In isolated cases - peripheral edema, hot flashes, sexual dysfunction.

Drug Interaction

The administration of Albarel with tricyclic antidepressants reduces its antihypertensive effect.

The Albarelle effect is enhanced by vasodilators, diuretics and antihistamines.

When combined with drugs that have a CNS depressant effect, drowsiness may increase.

Overdose

Symptoms: marked arterial hypotension, mental disorders.

Treatment: gastric lavage then sympathomimetic therapy. Rilmenidine is poorly excreted in hemodialysis.

Storage conditions

The drug should be stored at a temperature not exceeding 30 ° C.

Expiration

2 years.

Deystvuyuschee substances

Rilmenidine

Pharmacy terms of sale

Prescription

tablet dosage form

Formulation





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